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gchfr GTP cyclohydrolase I feedback regulator [ Danio rerio (zebrafish) ]

Gene ID: 393735, updated on 27-Mar-2024

Summary

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Official Symbol
gchfrprovided by ZNC
Official Full Name
GTP cyclohydrolase I feedback regulatorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1731
See related
Ensembl:ENSDARG00000098588 AllianceGenome:ZFIN:ZDB-GENE-040426-1731
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:73253
Summary
Predicted to enable GTP cyclohydrolase binding activity. Predicted to be involved in negative regulation of GTP cyclohydrolase I activity. Predicted to act upstream of or within negative regulation of biosynthetic process. Predicted to be located in cytosol and nuclear membrane. Predicted to be active in cytoplasm and nucleus. Is expressed in liver. Orthologous to human GCHFR (GTP cyclohydrolase I feedback regulator). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 17
Exon count:
3
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (1063988..1069195)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (860033..865240)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2, regulatory subunit B', gamma a Neighboring gene cytochrome P450, family 1, subfamily C, polypeptide 2 Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 17 Neighboring gene cdc42 effector protein 3-like Neighboring gene inverted formin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution of pigment synthesis pathways by gene and genome duplication in fish. Braasch I, et al. BMC Evol Biol, 2007 May 11. PMID 17498288, Free PMC Article
  2. Identification and expression of liver-specific genes after LPS challenge in amphioxus: the hepatic cecum as liver-like organ and "pre-hepatic" acute phase response. Wang Y, et al. Funct Integr Genomics, 2011 Mar. PMID 21052758
  3. HNF factors form a network to regulate liver-enriched genes in zebrafish. Cheng W, et al. Dev Biol, 2006 Jun 15. PMID 16631158
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC73253

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP cyclohydrolase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GTP cyclohydrolase 1 feedback regulatory protein
Names
GFRP
GTP cyclohydrolase I feedback regulatory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200762.3 → NP_957056.1  GTP cyclohydrolase 1 feedback regulatory protein

    See identical proteins and their annotated locations for NP_957056.1

    Status: VALIDATED

    Source sequence(s)
    EH535515, EH551858
    UniProtKB/Swiss-Prot
    Q6PBT6
    Related
    ENSDARP00000135960.1, ENSDART00000160400.2
    Conserved Domains (1) summary
    pfam06399
    Location:3 → 83
    GFRP; GTP cyclohydrolase I feedback regulatory protein (GFRP)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    1063988..1069195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005158967.4 → XP_005159024.1  GTP cyclohydrolase 1 feedback regulatory protein isoform X1

    UniProtKB/TrEMBL
    A0A8M2B5F4
    Conserved Domains (1) summary
    pfam06399
    Location:3 → 82
    GFRP; GTP cyclohydrolase I feedback regulatory protein (GFRP)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PBT6.1 GenPept UniProtKB/Swiss-Prot:Q6PBT6

Gene LinkOut

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