ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ndufv2provided by ZNC
Official Full Name: NADH:ubiquinone oxidoreductase core subunit V2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1713
See related: Ensembl:ENSDARG00000013044 AllianceGenome:ZFIN:ZDB-GENE-040426-1713
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:73198
Summary: Predicted to enable 2 iron, 2 sulfur cluster binding activity; metal ion binding activity; and oxidoreductase activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be part of mitochondrial respiratory chain complex I. Is expressed in several structures, including alar plate midbrain region; digestive system; optic tectum; optic vesicle; and retina. Human ortholog(s) of this gene implicated in Parkinson's disease and nuclear type mitochondrial complex I deficiency 7. Orthologous to human NDUFV2 (NADH:ubiquinone oxidoreductase core subunit V2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (54641775..54690247)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (54911079..54960548)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
contributes_to NADH dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, NADH to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of mitochondrial respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

Names: NADH dehydrogenase (ubiquinone) flavoprotein 2

NP_957041.1

EC 7.1.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200747.1 → NP_957041.1 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

See identical proteins and their annotated locations for NP_957041.1

Status: PROVISIONAL

Source sequence(s)

BC059546

UniProtKB/TrEMBL

A0A8M1PEZ8, Q6PBX8

Related

ENSDARP00000004700.6, ENSDART00000027313.9

Conserved Domains (2) summary

COG1905
Location:46 → 206

NuoE; NADH:ubiquinone oxidoreductase 24 kD subunit (chain E) [Energy production and conversion]

pfam01257
Location:58 → 204

2Fe-2S_thioredx; Thioredoxin-like [2Fe-2S] ferredoxin