abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: abcc2provided by ZNC
Official Full Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1523
See related: Ensembl:ENSDARG00000014031 AllianceGenome:ZFIN:ZDB-GENE-040426-1523
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mrp2; zgc:66072
Summary: Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be integral component of plasma membrane. Predicted to be active in apical plasma membrane. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder (multiple); carcinoma (multiple); drug-induced hepatitis; leukemia (multiple); and non-alcoholic fatty liver disease. Orthologous to human ABCC2 (ATP binding cassette subfamily C member 2). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (681627..711588)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (551336..581297)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

characterization of ABCC2: amino acid sequence and alignment with human ABCC2; phylogeny with other ABCC proteins; spatiotemporal expression of ABCC2 in larva/embryo; organ specific expression; heavy metal induction; function in heavy metal excretion
Title: Molecular characterization and functions of zebrafish ABCC2 in cellular efflux of heavy metals.

Submit: New GeneRIF Correction

General gene information

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Markers

fb24g09.x1 (e-PCR)
- UniSTS:190342

fj45a04.x1 (e-PCR)
- UniSTS:199375

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ABC-type glutathione S-conjugate transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell redox homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: canalicular multispecific organic anion transporter 1

Names: multidrug resistance-associated protein member 2

NP_956883.2

EC 7.6.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200589.2 → NP_956883.2 canalicular multispecific organic anion transporter 1

See identical proteins and their annotated locations for NP_956883.2

Status: VALIDATED

Source sequence(s)

EH493464, HQ728869

UniProtKB/TrEMBL

F1DB26

Related

ENSDARP00000025026.7, ENSDART00000016604.8

Conserved Domains (5) summary

TIGR00957
Location:10 → 1555

MRP_assoc_pro; multi drug resistance-associated protein (MRP)

cd03244
Location:1316 → 1536

ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein

cd03250
Location:656 → 856

ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C

pfam00664
Location:1001 → 1270

ABC_membrane; ABC transporter transmembrane region

cl00549
Location:346 → 612

ABC_membrane; ABC transporter transmembrane region