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pdhx pyruvate dehydrogenase complex component X [ Danio rerio (zebrafish) ]

Gene ID: 393532, updated on 27-Mar-2024

Summary

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Official Symbol
pdhxprovided by ZNC
Official Full Name
pyruvate dehydrogenase complex component Xprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1539
See related
Ensembl:ENSDARG00000051756 AllianceGenome:ZFIN:ZDB-GENE-040426-1539
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:66110; zgc:85977
Summary
Predicted to enable acyltransferase activity, transferring groups other than amino-acyl groups. Predicted to be part of pyruvate dehydrogenase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHX (pyruvate dehydrogenase complex component X). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 25
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (37428187..37435076, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (36857629..36864546, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 1 member 2b Neighboring gene CD44 molecule (IN blood group) b Neighboring gene charged multivesicular body protein 1A Neighboring gene solute carrier family 10 member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Spatio-temporal regulation of Wnt and retinoic acid signaling by tbx16/spadetail during zebrafish mesoderm differentiation. Mueller RL, et al. BMC Genomics, 2010 Sep 9. PMID 20828405, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC66110

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables 2-methylhexanoyl-CoA C-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables keto acid formate lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within acetyl-CoA biosynthetic process from pyruvate IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of pyruvate dehydrogenase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of pyruvate dehydrogenase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pyruvate dehydrogenase protein X component, mitochondrial
NP_956854.2
XP_005170791.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200560.2 → NP_956854.2  pyruvate dehydrogenase protein X component, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    CU633770, EH482395, EH607208
    UniProtKB/TrEMBL
    A0A8M1PHE0, F1R0J8
    Related
    ENSDARP00000093629.2, ENSDART00000102855.4
    Conserved Domains (4) summary
    cd06849
    Location:64 → 137
    lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
    TIGR01349
    Location:64 → 494
    PDHac_trf_mito; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
    pfam00198
    Location:287 → 494
    2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
    pfam02817
    Location:190 → 222
    E3_binding; e3 binding domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    37428187..37435076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005170734.4 → XP_005170791.1  pyruvate dehydrogenase protein X component, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8M2BI02
    Related
    ENSDARP00000124646.1, ENSDART00000148566.3
    Conserved Domains (4) summary
    cd06849
    Location:64 → 137
    lipoyl_domain; Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid ...
    TIGR01349
    Location:64 → 488
    PDHac_trf_mito; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form
    pfam00198
    Location:281 → 488
    2-oxoacid_dh; 2-oxoacid dehydrogenases acyltransferase (catalytic domain)
    pfam02817
    Location:184 → 216
    E3_binding; e3 binding domain
Nucleotide Protein Strain
Heading Accession and Version

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