fgfrl1a fibroblast growth factor receptor like 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fgfrl1aprovided by ZNC
Official Full Name: fibroblast growth factor receptor like 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040128-2
See related: Ensembl:ENSDARG00000032617 AllianceGenome:ZFIN:ZDB-GENE-040128-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fgfrl1; zgc:64084
Summary: Predicted to enable fibroblast growth factor binding activity and fibroblast growth factor-activated receptor activity. Acts upstream of or within animal organ development and digestive tract development. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including digestive system; immature eye; mesoderm; nervous system; and pharyngeal arch. Orthologous to human FGFRL1 (fibroblast growth factor receptor like 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (17442919..17563400, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (17137266..17257747, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In the absence of Fgfrl1a, larvae fail to express the transcription factor glial cells missing 2 (gcm2), a gene necessary for cartilage and gill filament formation, in the ectodermal lining of the branchial arches.
Title: An essential role for zebrafish Fgfrl1 during gill cartilage development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables L-iduronidase activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cartilage development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within digestive tract development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fourth ventricle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lateral ventricle development	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within swim bladder development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within third ventricle development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fibroblast growth factor receptor-like 1a

Names: fibroblast growth factor receptor-like 1

NP_956670.1

EC 3.2.1.76

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200376.1 → NP_956670.1 fibroblast growth factor receptor-like 1a precursor

See identical proteins and their annotated locations for NP_956670.1

Status: PROVISIONAL

Source sequence(s)

BC053245

UniProtKB/TrEMBL

A4JYK1, Q7SX76

Related

ENSDARP00000077102.4, ENSDART00000082667.6

Conserved Domains (4) summary

cd05856
Location:151 → 232

Ig2_FGFRL1-like; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor_like-1(FGFRL1)

smart00408
Location:38 → 101

IGc2; Immunoglobulin C-2 Type

pfam07679
Location:32 → 111

I-set; Immunoglobulin I-set domain

cl11960
Location:255 → 350

Ig; Immunoglobulin domain