chuk component of inhibitor of nuclear factor kappa B kinase complex [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: chukprovided by ZNC
Official Full Name: component of inhibitor of nuclear factor kappa B kinase complexprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1069
See related: Ensembl:ENSDARG00000011662 AllianceGenome:ZFIN:ZDB-GENE-040426-1069
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ikk1; zgc:56539
Summary: Predicted to enable protein heterodimerization activity; protein homodimerization activity; and protein serine/threonine kinase activity. Predicted to contribute to IkappaB kinase activity. Acts upstream of or within several processes, including epiboly involved in gastrulation with mouth forming second; negative regulation of I-kappaB kinase/NF-kappaB signaling; and somite specification. Predicted to be located in nucleus. Predicted to be part of IkappaB kinase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including immature eye; nervous system; notochord; pectoral fin; and segmental plate. Human ortholog(s) of this gene implicated in fetal encasement syndrome and prostate cancer. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (25365069..25379640)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (25234619..25249190)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings reveal a molecular mechanism regulating migration and invasion of epithelial cells and establish a key direct link between IKKbeta and cell motility controlled by Rap-integrin signaling.
Title: Control of epithelial cell migration and invasion by the IKKβ- and CK1α-mediated degradation of RAPGEF2.
poky/chuk/ikk1 is required for differentiation of the zebrafish embryonic epidermis
Title: poky/chuk/ikk1 is required for differentiation of the zebrafish embryonic epidermis.
Ikk1 negatively regulates NF-kappaB by sequestering NEMO from active IKK complexes, indicating that IKK1 can function as a repressor of NF-kappaB.
Title: Zebrafish IkappaB kinase 1 negatively regulates NF-kappaB activity.

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General gene information

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Markers

fi22h03.y1 (e-PCR)
- UniSTS:197054

fi84b07.y1 (e-PCR)
- UniSTS:198093

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
contributes_to IkappaB kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables IkappaB kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
NOT acts_upstream_of_or_within I-kappaB phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to tumor necrosis factor	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epiboly involved in gastrulation with mouth forming second	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of NF-kappaB transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within somite specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of IkappaB kinase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inhibitor of nuclear factor kappa-B kinase subunit alpha

Names: I-kappa-B kinase 1; IKK-A; IKK-alpha; IKKa; NFKBIKA; conserved helix-loop-helix ubiquitous kinase; i kappa-B kinase alpha; ikBKA; ikappaB kinase; nuclear factor NF-kappa-B inhibitor kinase alpha; pky

NP_956611.1

EC 2.7.11.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200317.1 → NP_956611.1 inhibitor of nuclear factor kappa-B kinase subunit alpha

See identical proteins and their annotated locations for NP_956611.1

Status: PROVISIONAL

Source sequence(s)

BC051614

UniProtKB/Swiss-Prot

Q4G3H4, Q7ZTU1

Related

ENSDARP00000013115.8, ENSDART00000027428.9

Conserved Domains (3) summary

smart00220
Location:15 → 288

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam12179
Location:712 → 746

IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain

cl21453
Location:21 → 310

PKc_like; Protein Kinases, catalytic domain