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chuk component of inhibitor of nuclear factor kappa B kinase complex [ Danio rerio (zebrafish) ]

Gene ID: 393287, updated on 4-Jan-2025

Summary

Official Symbol
chukprovided by ZNC
Official Full Name
component of inhibitor of nuclear factor kappa B kinase complexprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1069
See related
Ensembl:ENSDARG00000011662 AllianceGenome:ZFIN:ZDB-GENE-040426-1069
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ikk1; zgc:56539
Summary
Predicted to enable protein heterodimerization activity; protein homodimerization activity; and protein serine/threonine kinase activity. Predicted to contribute to IkappaB kinase activity. Acts upstream of or within several processes, including epiboly involved in gastrulation with mouth forming second; negative regulation of canonical NF-kappaB signal transduction; and somite specification. Predicted to be located in nucleus. Predicted to be part of IkappaB kinase complex. Predicted to be active in cytoplasm. Is expressed in several structures, including immature eye; nervous system; notochord; pectoral fin; and segmental plate. Human ortholog(s) of this gene implicated in fetal encasement syndrome; liver cancer; and prostate cancer. Orthologous to human CHUK (component of inhibitor of nuclear factor kappa B kinase complex). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See chuk in Genome Data Viewer
Location:
chromosome: 13
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (25365069..25379640)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (25234619..25249190)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene vinculin a Neighboring gene plasminogen activator, urokinase a Neighboring gene glutathione S-transferase omega 1 Neighboring gene glutathione S-transferase omega 2

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Pathways from PubChem

General gene information

Clone Names

  • MGC56539

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding  
contributes_to IkappaB kinase activity  
enables IkappaB kinase activity  
enables kinase activity  
enables nucleotide binding  
enables protein binding PubMed 
enables protein heterodimerization activity  
enables protein homodimerization activity  
enables protein kinase activity  
enables protein serine/threonine kinase activity  
enables protein serine/threonine kinase activity  
enables transferase activity  
Process Evidence Code Pubs
NOT acts_upstream_of_or_within I-kappaB phosphorylation PubMed 
involved_in cellular response to tumor necrosis factor  
acts_upstream_of_or_within central nervous system development PubMed 
acts_upstream_of_or_within epiboly involved in gastrulation with mouth forming second PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
acts_upstream_of_or_within negative regulation of canonical NF-kappaB signal transduction PubMed 
acts_upstream_of_or_within phosphorylation  
involved_in positive regulation of canonical NF-kappaB signal transduction  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of transcription by RNA polymerase II  
acts_upstream_of_or_within protein phosphorylation  
acts_upstream_of_or_within somite specification PubMed 
involved_in tumor necrosis factor-mediated signaling pathway  
Component Evidence Code Pubs
part_of IkappaB kinase complex  
is_active_in cytoplasm  
located_in cytoplasm  
located_in nucleus  

General protein information

Preferred Names
inhibitor of nuclear factor kappa-B kinase subunit alpha
Names
I-kappa-B kinase 1
IKK-A
IKK-alpha
IKKa
NFKBIKA
conserved helix-loop-helix ubiquitous kinase
i kappa-B kinase alpha
ikBKA
ikappaB kinase
nuclear factor NF-kappa-B inhibitor kinase alpha
pky
NP_956611.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200317.1NP_956611.1  inhibitor of nuclear factor kappa-B kinase subunit alpha

    See identical proteins and their annotated locations for NP_956611.1

    Status: PROVISIONAL

    Source sequence(s)
    BC051614
    UniProtKB/Swiss-Prot
    Q4G3H4, Q7ZTU1
    Related
    ENSDARP00000013115.8, ENSDART00000027428.9
    Conserved Domains (3) summary
    smart00220
    Location:15288
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12179
    Location:712746
    IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain
    cl21453
    Location:21310
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    25365069..25379640
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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