ncor1 nuclear receptor corepressor 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ncor1provided by ZNC
Official Full Name: nuclear receptor corepressor 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-993
See related: Ensembl:ENSDARG00000035285 AllianceGenome:ZFIN:ZDB-GENE-040426-993
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ncor; zgc:56355
Summary: Predicted to enable thyroid hormone receptor binding activity and transcription corepressor activity. Acts upstream of or within anterior/posterior pattern specification; hindbrain development; and neutrophil differentiation. Is expressed in several structures, including epidermis; head; liver; pleuroperitoneal region; and ventricular system. Orthologous to human NCOR1 (nuclear receptor corepressor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 49

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (41878247..41996537, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (41278099..41396358, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ncor1 and Ncor2 play essential but distinct roles in zebrafish primitive myelopoiesis
Title: Ncor1 and Ncor2 play essential but distinct roles in zebrafish primitive myelopoiesis.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables nuclear thyroid hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hindbrain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neutrophil differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nuclear receptor corepressor 1

Names: nuclear receptor co-repressor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200276.2 → NP_956570.2 nuclear receptor corepressor 1

See identical proteins and their annotated locations for NP_956570.2

Status: PROVISIONAL

Source sequence(s)

EF016488

UniProtKB/TrEMBL

A8B6H7

Conserved Domains (3) summary

smart00717
Location:641 → 686

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:641 → 684

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam15784
Location:141 → 225

GPS2_interact; G-protein pathway suppressor 2-interacting domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

41878247..41996537 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009301628.3 → XP_009299903.1 nuclear receptor corepressor 1 isoform X2

UniProtKB/TrEMBL

A0A8M3AZS6

Conserved Domains (3) summary

smart00717
Location:640 → 685

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:640 → 683

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam15784
Location:141 → 225

GPS2_interact; G-protein pathway suppressor 2-interacting domain
XM_009301631.3 → XP_009299906.1 nuclear receptor corepressor 1 isoform X5

UniProtKB/TrEMBL

A0A8M3B9S7

Conserved Domains (3) summary

smart00717
Location:641 → 686

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:641 → 684

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam15784
Location:141 → 225

GPS2_interact; G-protein pathway suppressor 2-interacting domain
XM_009301630.3 → XP_009299905.1 nuclear receptor corepressor 1 isoform X3

UniProtKB/TrEMBL

A0A8M3ASH4

Related

ENSDARP00000120166.1, ENSDART00000143573.2

Conserved Domains (3) summary

smart00717
Location:641 → 686

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:641 → 684

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam15784
Location:141 → 225

GPS2_interact; G-protein pathway suppressor 2-interacting domain
XM_005165283.4 → XP_005165340.1 nuclear receptor corepressor 1 isoform X4

UniProtKB/TrEMBL

A0A8M2BCM0

Conserved Domains (3) summary

smart00717
Location:641 → 686

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:641 → 684

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam15784
Location:141 → 225

GPS2_interact; G-protein pathway suppressor 2-interacting domain
XM_009301627.3 → XP_009299902.1 nuclear receptor corepressor 1 isoform X1

UniProtKB/TrEMBL

A0A8M3B2M9

Conserved Domains (3) summary

smart00717
Location:641 → 686

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:641 → 684

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

pfam15784
Location:141 → 225

GPS2_interact; G-protein pathway suppressor 2-interacting domain
XM_009301635.3 → XP_009299910.1 nuclear receptor corepressor 1 isoform X9

UniProtKB/TrEMBL

A0A8M3AZS8

Related

ENSDARP00000088345.3, ENSDART00000097574.4

Conserved Domains (2) summary

smart00717
Location:151 → 196

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:151 → 194

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_009301634.3 → XP_009299909.1 nuclear receptor corepressor 1 isoform X8

UniProtKB/TrEMBL

A0A8M3B2N4

Conserved Domains (2) summary

smart00717
Location:152 → 197

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:152 → 195

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_009301633.3 → XP_009299908.1 nuclear receptor corepressor 1 isoform X7

UniProtKB/TrEMBL

A0A8M3ASM4

Conserved Domains (2) summary

smart00717
Location:156 → 201

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd00167
Location:156 → 199

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
XM_021476034.1 → XP_021331709.1 nuclear receptor corepressor 1 isoform X6

UniProtKB/TrEMBL

A0A8M9Q2Z1

Conserved Domains (1) summary

smart00717
Location:157 → 202

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains