pemt phosphatidylethanolamine N-methyltransferase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pemtprovided by ZNC
Official Full Name: phosphatidylethanolamine N-methyltransferaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-719
See related: AllianceGenome:ZFIN:ZDB-GENE-040426-719
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55479
Summary: Predicted to enable phosphatidylethanolamine N-methyltransferase activity. Predicted to be involved in phosphatidylcholine biosynthetic process. Predicted to act upstream of or within methylation and phospholipid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane and mitochondrial membrane. Predicted to be integral component of membrane. Orthologous to human PEMT (phosphatidylethanolamine N-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (1286531..1388444)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (1286973..1360126)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables S-adenosylmethionine-dependent methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidyl-N-dimethylethanolamine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidyl-N-methylethanolamine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylethanolamine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylethanolamine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphatidylcholine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphatidylethanolamine N-methyltransferase

NP_956452.1

EC 2.1.1.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200158.1 → NP_956452.1 phosphatidylethanolamine N-methyltransferase

See identical proteins and their annotated locations for NP_956452.1

Status: PROVISIONAL

Source sequence(s)

BC045355

UniProtKB/TrEMBL

Q7ZVZ2

Conserved Domains (1) summary

pfam04191
Location:121 → 223

PEMT; Phospholipid methyltransferase