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RPSA ribosomal protein SA [ Homo sapiens (human) ]

Gene ID: 3921, updated on 7-Apr-2024

Summary

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Official Symbol
RPSAprovided by HGNC
Official Full Name
ribosomal protein SAprovided by HGNC
Primary source
HGNC:HGNC:6502
See related
Ensembl:ENSG00000168028 MIM:150370; AllianceGenome:HGNC:6502
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SA; LBP; LRP; p40; uS2; 67LR; ICAS; lamR; 37LRP; LAMBR; LAMR1; LRP/LR; LBP/p40; NEM/1CHD4
Summary
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 792.7), lymph node (RPKM 583.0) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
3p22.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (39406720..39412542)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (39419647..39425467)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (39448211..39454033)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377037 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14225 Neighboring gene uncharacterized LOC105377644 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19706 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19707 Neighboring gene solute carrier family 25 member 38 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:39445554-39446346 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:39447932-39448723 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14228 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:39450309-39451100 Neighboring gene uncharacterized LOC107986075 Neighboring gene small nucleolar RNA, H/ACA box 6 Neighboring gene small nucleolar RNA, H/ACA box 62 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14229 Neighboring gene NANOG hESC enhancer GRCh37_chr3:39508789-39509471 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:39513805-39514612 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:39514613-39515420 Neighboring gene myelin associated oligodendrocyte basic protein Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:39547383-39547882

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LAMR1 restricts Zika virus infection by attenuating the envelope protein ubiquitination. Hu D, et al. Virulence, 2021 Dec. PMID 34282707, Free PMC Article
  2. Identification of the Neuroinvasive Pathogen Host Target, LamR, as an Endothelial Receptor for the Treponema pallidum Adhesin Tp0751. Lithgow KV, et al. mSphere, 2020 Apr 1. PMID 32238570, Free PMC Article
  3. LRP::FLAG Rescues Cells from Amyloid-β-Mediated Cytotoxicity Through Increased TERT Levels and Telomerase Activity. Bignoux MJ, et al. J Alzheimers Dis, 2019. PMID 31081791
  4. Lysines residing in putative Small Ubiquitin-like MOdifier (SUMO) motifs regulate fate and function of 37 KDa laminin receptor. Umbaugh CS, et al. Biochimie, 2019 Jan. PMID 30315854
  5. Incomplete penetrance for isolated congenital asplenia in humans with mutations in translated and untranslated RPSA exons. Bolze A, et al. Proc Natl Acad Sci U S A, 2018 Aug 21. PMID 30072435, Free PMC Article

See all (317) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ribosomal protein SA is a common component of neuronal intranuclear inclusions in polyglutamine diseases and Marinesco bodies.
    Title: Ribosomal protein SA is a common component of neuronal intranuclear inclusions in polyglutamine diseases and Marinesco bodies.
  2. LAMR1 restricts Zika virus infection by attenuating the envelope protein ubiquitination.
    Title: LAMR1 restricts Zika virus infection by attenuating the envelope protein ubiquitination.
  3. The role of LR-TIMAP/PP1c complex in the occurrence and development of no-reflow.
    Title: The role of LR-TIMAP/PP1c complex in the occurrence and development of no-reflow.
  4. AG-9, an Elastin-Derived Peptide, Increases In Vitro Oral Tongue Carcinoma Cell Invasion, through an Increase in MMP-2 Secretion and MT1-MMP Expression, in a RPSA-Dependent Manner.
    Title: AG-9, an Elastin-Derived Peptide, Increases In Vitro Oral Tongue Carcinoma Cell Invasion, through an Increase in MMP-2 Secretion and MT1-MMP Expression, in a RPSA-Dependent Manner.
  5. Mutations in RPSA and NKX2-3 link development of the spleen and intestinal vasculature.
    Title: Mutations in RPSA and NKX2-3 link development of the spleen and intestinal vasculature.
  6. MicroRNA-587 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Targeting Ribosomal Protein SA.
    Title: MicroRNA-587 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Targeting Ribosomal Protein SA.
  7. Dentate gyrus volume deficit in schizophrenia.
    Title: Dentate gyrus volume deficit in schizophrenia.
  8. Identification of the Neuroinvasive Pathogen Host Target, LamR, as an Endothelial Receptor for the Treponema pallidum Adhesin Tp0751.
    Title: Identification of the Neuroinvasive Pathogen Host Target, LamR, as an Endothelial Receptor for the Treponema pallidum Adhesin Tp0751.
  9. LRP::FLAG Rescues Cells from Amyloid-beta-Mediated Cytotoxicity Through Increased TERT Levels and Telomerase Activity.
    Title: LRP::FLAG Rescues Cells from Amyloid-β-Mediated Cytotoxicity Through Increased TERT Levels and Telomerase Activity.
  10. The development of drugs targeting both ITGA6 and RPSA may be an effective strategy for the treatment of pancreatic cancer.
    Title: ITGA6 and RPSA synergistically promote pancreatic cancer invasion and metastasis via PI3K and MAPK signaling pathways.
Submit: New GeneRIF Correction See all GeneRIFs (89)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Familial isolated congenital asplenia
MedGen: C0685889 OMIM: 271400 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev interacting protein, ribosomal protein SA (RPSA), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables laminin binding IEA
Inferred from Electronic Annotation
more info
  
enables laminin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosome binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome HDA PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables virus receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in symbiont entry into host cell IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in membrane HDA PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
small ribosomal subunit protein uS2
Names
37 kDa laminin receptor
37/67 kDa laminin receptor
40S ribosomal protein SA
67 kDa laminin receptor
colon carcinoma laminin-binding protein
laminin receptor 1 (67kD, ribosomal protein SA)
laminin-binding protein precursor p40
multidrug resistance-associated protein MGr1-Ag

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033234.1 RefSeqGene

    Range
    5008..10830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_735

mRNA and Protein(s)

  1. NM_001304288.2 → NP_001291217.1  small ribosomal subunit protein uS2 isoform 2

    See identical proteins and their annotated locations for NP_001291217.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is longer compared to isoform 1.
    Source sequence(s)
    BC070263, BC071968, BM999786, X15005
    Consensus CDS
    CCDS77723.1
    UniProtKB/TrEMBL
    A0A0C4DG17, Q96RS2
    Related
    ENSP00000389351.1, ENST00000443003.2
    Conserved Domains (1) summary
    PTZ00254
    Location:1 → 255
    PTZ00254; 40S ribosomal protein SA; Provisional

  2. NM_002295.6 → NP_002286.2  small ribosomal subunit protein uS2 isoform 1

    See identical proteins and their annotated locations for NP_002286.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    BC070263, BC071968, BM999786
    Consensus CDS
    CCDS2686.1
    UniProtKB/Swiss-Prot
    P08865, P11085, P12030, Q16471, Q6IPD1, Q6IPD2, Q6NSD1, Q6NXQ8, Q86VC0
    UniProtKB/TrEMBL
    Q96RS2
    Related
    ENSP00000346067.4, ENST00000301821.11
    Conserved Domains (1) summary
    PTZ00254
    Location:1 → 250
    PTZ00254; 40S ribosomal protein SA; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    39406720..39412542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    39419647..39425467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08865.4 GenPept UniProtKB/Swiss-Prot:P08865

Gene LinkOut

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