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hay haywire [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39202, updated on 4-Apr-2024

Summary

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Official Symbol
hayprovided by FlyBase
Official Full Name
haywireprovided by FlyBase
Primary source
FLYBASE:FBgn0001179
Locus tag
Dmel_CG8019
See related
AllianceGenome:FB:FBgn0001179
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8019; DhR25; DhXPB; Dmel\CG8019; DmXPB; ERCC3; Hay; hwr; i50; ms(3)nc2; nc2; TFIIH; Xpb; XPB; Xpb/hay
Summary
Predicted to enable 3'-5' DNA helicase activity. Involved in response to UV and transcription initiation from RNA polymerase II promoter. Located in nucleus. Part of transcription factor TFIIH holo complex. Is expressed in adult head; organism; and wing disc. Used to study Cockayne syndrome and xeroderma pigmentosum. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; photosensitive trichothiodystrophy 2; trichothiodystrophy; xeroderma pigmentosum; and xeroderma pigmentosum group B. Orthologous to human ERCC3 (ERCC excision repair 3, TFIIH core complex helicase subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
67E5-67E5; 3-33 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (10631079..10633969)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (10624179..10627069)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Enhancer of zeste Neighboring gene CTD nuclear envelope phosphatase 1 regulatory subunit 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Towards an understanding of the genetics of human male infertility: lessons from flies. Hackstein JH, et al. Trends Genet, 2000 Dec. PMID 11102707
  2. Xeroderma pigmentosum and nucleotide excision repair of DNA. Tanaka K, et al. Trends Biochem Sci, 1994 Feb. PMID 8160271
  3. Transcription-coupled repair and human disease. Hanawalt PC. Science, 1994 Dec 23. PMID 7801121
  4. Xeroderma pigmentosum, Cockayne's syndrome, helicases, and DNA repair: what's the relationship? Friedberg EC. Cell, 1992 Dec 11. PMID 1458537
  5. Cloning and characterization of the Drosophila homolog of the xeroderma pigmentosum complementation-group B correcting gene, ERCC3. Koken MH, et al. Nucleic Acids Res, 1992 Nov 11. PMID 1454518, Free PMC Article

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The data demonstrate that dMYC repression and dMYC-dependent overgrowth in the Hfp hypomorph is further impaired in the C-terminal Hay/XPB mutant background.
    Title: Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models.
  2. analysis of physical and functional interactions between Drosophila homologue of Swc6/p18Hamlet subunit of the SWR1/SRCAP chromatin-remodeling complex with the DNA repair/transcription factor TFIIH
    Title: Physical and functional interactions between Drosophila homologue of Swc6/p18Hamlet subunit of the SWR1/SRCAP chromatin-remodeling complex with the DNA repair/transcription factor TFIIH.
  3. regulation of dmyc requires interaction between the transcriptional repressor Hfp and the DNA helicase subunit of TFIIH, Haywire (Hay)
    Title: Hfp inhibits Drosophila myc transcription and cell growth in a TFIIH/Hay-dependent manner.
  4. TFIIH is a basal transcription factor, but mutations in the subunit encoded by hay have specific effects in the transcription of some genes.
    Title: RNA polymerase II 140wimp mutant and mutations in the TFIIH subunit XPB differentially affect homeotic gene expression in Drosophila.
  5. Drosophila TFIIH (hay) has roles in DNA repair and transcription
    Title: DNA repair and transcriptional effects of mutations in TFIIH in Drosophila development.
  6. TFIIH core is initially located in the cytoplasm of syncytial blastoderm embryos, and that after mitotic division ten and until the cellular blastoderm stage, the core moves from the cytoplasm to the nucleus.
    Title: TFIIH trafficking and its nuclear assembly during early Drosophila embryo development.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-5' DNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II promoter clearance ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in nucleotide-excision repair IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide-excision repair ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in response to UV IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription initiation at RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription initiation at RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in transcription open complex formation at RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of nucleotide-excision repair factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIIH holo complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIH holo complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIIH holo complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of transcription factor TFIIH holo complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of transcription preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
haywire
Names
CG8019-PA
CG8019-PB
hay-PA
hay-PB
NP_001137931.1
NP_524020.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    10631079..10633969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079296.4 → NP_524020.2  haywire, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524020.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q02870, Q1LZ27, Q2PJB4, Q960M8, Q9VTA2
    UniProtKB/TrEMBL
    B7Z0G1
    Related
    FBpp0075982
    Conserved Domains (4) summary
    TIGR00603
    Location:70 → 795
    rad25; DNA repair helicase rad25
    pfam04851
    Location:331 → 488
    ResIII; Type III restriction enzyme, res subunit
    pfam13625
    Location:86 → 208
    Helicase_C_3; Helicase conserved C-terminal domain
    pfam16203
    Location:512 → 756
    ERCC3_RAD25_C; ERCC3/RAD25/XPB C-terminal helicase

  2. NM_001144459.2 → NP_001137931.1  haywire, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137931.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q02870, Q1LZ27, Q2PJB4, Q960M8, Q9VTA2
    UniProtKB/TrEMBL
    B7Z0G1
    Conserved Domains (4) summary
    TIGR00603
    Location:70 → 795
    rad25; DNA repair helicase rad25
    pfam04851
    Location:331 → 488
    ResIII; Type III restriction enzyme, res subunit
    pfam13625
    Location:86 → 208
    Helicase_C_3; Helicase conserved C-terminal domain
    pfam16203
    Location:512 → 756
    ERCC3_RAD25_C; ERCC3/RAD25/XPB C-terminal helicase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7Z0G1 B7Z0G1
Q02870.2 Q02870

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