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Cdc6 Cell division cycle 6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38989, updated on 4-Apr-2024

Summary

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Official Symbol
Cdc6provided by FlyBase
Official Full Name
Cell division cycle 6provided by FlyBase
Primary source
FLYBASE:FBgn0035918
Locus tag
Dmel_CG5971
See related
AllianceGenome:FB:FBgn0035918
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cdc6; CDC6; CG5971; DmCdc6; Dmel\CG5971
Summary
Predicted to enable DNA replication origin binding activity. Predicted to be involved in mitotic DNA replication checkpoint signaling. Located in nucleus. Is expressed in several structures, including embryonic/larval midgut; extended germ band embryo; larval ventral nerve cord; and ventral midline of embryo. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 5. Orthologous to human CDC6 (cell division cycle 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
66D9-66D9; 3-26 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8631509..8634069, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8624609..8627169, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Sperm-Leucylaminopeptidase 1 Neighboring gene Sperm-Leucylaminopeptidase 2 Neighboring gene GTPase activating protein, SECIS-dependent read-through Neighboring gene Z band alternatively spliced PDZ-motif protein 66 Neighboring gene Cuticular protein 66D Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Juvenile Hormone Activates the Transcription of Cell-division-cycle 6 (Cdc6) for Polyploidy-dependent Insect Vitellogenesis and Oogenesis. Wu Z, et al. J Biol Chem, 2016 Mar 4. PMID 26728459, Free PMC Article
  2. Molecular evolution of Drosophila Cdc6, an essential DNA replication-licensing gene, suggests an adaptive choice of replication origins. Wiggins BL, et al. Fly (Austin), 2007 May-Jun. PMID 18618020, Free PMC Article
  3. Differential condensation of sister chromatids acts with Cdc6 to ensure asynchronous S-phase entry in Drosophila male germline stem cell lineage. Ranjan R, et al. Dev Cell, 2022 May 9. PMID 35483360, Free PMC Article
  4. Polyploidy in the adult Drosophila brain. Nandakumar S, et al. Elife, 2020 Aug 25. PMID 32840209, Free PMC Article
  5. Forced binding of the origin of replication complex to chromosomal sites in Drosophila S2 cells creates an origin of replication. Crevel G, et al. J Cell Sci, 2012 Feb 15. PMID 22421364

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6.
    Title: Structural mechanism for replication origin binding and remodeling by a metazoan origin recognition complex and its co-loader Cdc6.
  2. Cdc6 transcription is directly regulated by the juvenile hormone-receptor complex. Knockdown of Cdc6 inhibits polyploidization of fat body and follicle cells.
    Title: Juvenile Hormone Activates the Transcription of Cell-division-cycle 6 (Cdc6) for Polyploidy-dependent Insect Vitellogenesis and Oogenesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cell division cycle 6
Names
CG5971-PA
Cdc6-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    8631509..8634069 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139990.3 → NP_648247.1  cell division cycle 6 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648247.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q06K02, Q9VSM9
    Related
    FBpp0076371
    Conserved Domains (3) summary
    smart01074
    Location:564 → 644
    Cdc6_C; CDC6, C terminal
    TIGR02928
    Location:266 → 623
    TIGR02928; orc1/cdc6 family replication initiation protein
    pfam13401
    Location:288 → 407
    AAA_22; AAA domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VSM9 Q9VSM9

Gene LinkOut

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