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KTN1 kinectin 1 [ Homo sapiens (human) ]

Gene ID: 3895, updated on 7-Apr-2024

Summary

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Official Symbol
KTN1provided by HGNC
Official Full Name
kinectin 1provided by HGNC
Primary source
HGNC:HGNC:6467
See related
Ensembl:ENSG00000126777 MIM:600381; AllianceGenome:HGNC:6467
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CG1; KNT; MU-RMS-40.19
Summary
This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2012]
Expression
Ubiquitous expression in testis (RPKM 35.7), thyroid (RPKM 26.9) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
14q22.3
Exon count:
47
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (55580207..55684584)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (49785926..49890300)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (56046925..56151302)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene abl interactor 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8434 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8435 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5786 Neighboring gene Sharpr-MPRA regulatory region 13870 Neighboring gene KTN1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:56166391-56166991 Neighboring gene uncharacterized LOC124903320 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:56219189-56219804 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:56219806-56220357 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:56220358-56220908 Neighboring gene ribosomal protein L13a pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Associations of attention distractibility with attention deficit and with variation in the KTN1 gene. Tuvi I, et al. Neurosci Lett, 2020 Nov 1. PMID 32956741
  2. KTN1 variants and risk for attention deficit hyperactivity disorder. Luo X, et al. Am J Med Genet B Neuropsychiatr Genet, 2020 Jun. PMID 32190980, Free PMC Article
  3. Significant, replicable, and functional associations between KTN1 variants and alcohol and drug codependence. Luo X, et al. Addict Biol, 2021 Mar. PMID 32115811, Free PMC Article
  4. Kinectin-dependent ER transport supports the focal complex maturation required for chemotaxis in shallow gradients. Ng IC, et al. J Cell Sci, 2016 Jul 1. PMID 27221621
  5. Kinectin-dependent assembly of translation elongation factor-1 complex on endoplasmic reticulum regulates protein synthesis. Ong LL, et al. J Biol Chem, 2006 Nov 3. PMID 16950774

See all (144) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A genetic and transcriptomic assessment of the KTN1 gene in Parkinson's disease risk.
    Title: A genetic and transcriptomic assessment of the KTN1 gene in Parkinson's disease risk.
  2. Significant, replicable, and functional associations between KTN1 variants and alcohol and drug codependence.
    Title: Significant, replicable, and functional associations between KTN1 variants and alcohol and drug codependence.
  3. Kinectin 1 promotes the growth of triple-negative breast cancer via directly co-activating NF-kappaB/p65 and enhancing its transcriptional activity.
    Title: Kinectin 1 promotes the growth of triple-negative breast cancer via directly co-activating NF-kappaB/p65 and enhancing its transcriptional activity.
  4. Human microRNA-182-5p and kinectin 1: Potential biomarkers for prognosis in oral squamous cell carcinoma.
    Title: Human microRNA-182-5p and kinectin 1: Potential biomarkers for prognosis in oral squamous cell carcinoma.
  5. Associations of attention distractibility with attention deficit and with variation in the KTN1 gene.
    Title: Associations of attention distractibility with attention deficit and with variation in the KTN1 gene.
  6. Rab18 regulates focal adhesion dynamics by interacting with kinectin-1 at the endoplasmic reticulum.
    Title: Rab18 regulates focal adhesion dynamics by interacting with kinectin-1 at the endoplasmic reticulum.
  7. KTN1 variants and risk for attention deficit hyperactivity disorder.
    Title: KTN1 variants and risk for attention deficit hyperactivity disorder.
  8. Erbb2 interacting protein (ERBB2IP), a known target of miR-23c, was positively regulated by KTN1-AS1.
    Title: LncRNA KTN1-AS1 promotes tumor growth of hepatocellular carcinoma by targeting miR-23c/ERBB2IP axis.
  9. Significant association between rs12895072 and rs12434554 within the KTN1 gene and accelerated decline in Cognition performance in Chinese elderly male Gout population.
    Title: Potential contribution of the neurodegenerative disorders risk loci to cognitive performance in an elderly male gout population.
  10. Our results show that kinectin-dependent ER distribution can be localized by chemoattractants and provide a mechanism for biased protrusion choices during chemotaxis in shallow gradients of chemoattractants.
    Title: Kinectin-dependent ER transport supports the focal complex maturation required for chemotaxis in shallow gradients.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0004, MGC133337

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables cadherin binding HDA PubMed 
enables kinesin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
  
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
  
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in membrane HDA PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
kinectin
Names
CG-1 antigen
kinesin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079521.2 → NP_001072989.1  kinectin isoform a

    See identical proteins and their annotated locations for NP_001072989.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (a).
    Source sequence(s)
    AL138499, AY536375, BQ014936, DA769269, Z22551
    Consensus CDS
    CCDS41957.1
    UniProtKB/Swiss-Prot
    B4DZ88, Q13999, Q14707, Q15387, Q17RZ5, Q5GGW3, Q86UP2, Q86W57
    Related
    ENSP00000378725.3, ENST00000395314.8
    Conserved Domains (3) summary
    COG1196
    Location:667 → 1352
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12128
    Location:319 → 991
    DUF3584; Protein of unknown function (DUF3584)
    cl23763
    Location:1013 → 1202
    MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain

  2. NM_001079522.2 → NP_001072990.1  kinectin isoform b

    See identical proteins and their annotated locations for NP_001072990.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks two alternate in-frame exons in the coding region compared to variant 2. This variant encodes isoform b, which is shorter than isoform a.
    Source sequence(s)
    BC117132, BQ014936, DA452468, DA769269
    Consensus CDS
    CCDS41959.1
    UniProtKB/Swiss-Prot
    Q86UP2
    Related
    ENSP00000378722.1, ENST00000395311.5
    Conserved Domains (2) summary
    TIGR02168
    Location:458 → 1246
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl23763
    Location:990 → 1179
    MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain

  3. NM_001271014.2 → NP_001257943.1  kinectin isoform d

    See identical proteins and their annotated locations for NP_001257943.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon in the coding region compared to variant 2. This variant encodes isoform d, which is shorter than isoform a.
    Source sequence(s)
    AK302797, BC143720, BM981127, DA769269
    UniProtKB/Swiss-Prot
    Q86UP2
    Conserved Domains (2) summary
    COG1196
    Location:326 → 1084
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl23763
    Location:1013 → 1202
    MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain

  4. NM_001402682.1 → NP_001389611.1  kinectin isoform a

    Status: REVIEWED

    Source sequence(s)
    AL138499
    Consensus CDS
    CCDS41957.1
    UniProtKB/Swiss-Prot
    B4DZ88, Q13999, Q14707, Q15387, Q17RZ5, Q5GGW3, Q86UP2, Q86W57

  5. NM_001402683.1 → NP_001389612.1  kinectin isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL138499

  6. NM_001402684.1 → NP_001389613.1  kinectin isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL138499

  7. NM_001402685.1 → NP_001389614.1  kinectin isoform d

    Status: REVIEWED

    Source sequence(s)
    AL138499

  8. NM_001402686.1 → NP_001389615.1  kinectin isoform d

    Status: REVIEWED

    Source sequence(s)
    AL138499

  9. NM_001402687.1 → NP_001389616.1  kinectin isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL138499

  10. NM_001402688.1 → NP_001389617.1  kinectin isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL138499

  11. NM_001402689.1 → NP_001389618.1  kinectin isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL138499

  12. NM_001402690.1 → NP_001389619.1  kinectin isoform 21

    Status: REVIEWED

    Source sequence(s)
    AL138499

  13. NM_001402691.1 → NP_001389620.1  kinectin isoform b

    Status: REVIEWED

    Source sequence(s)
    AL138499
    Related
    ENSP00000394992.2, ENST00000413890.6

  14. NM_001402692.1 → NP_001389621.1  kinectin isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL138499

  15. NM_001402693.1 → NP_001389622.1  kinectin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL138499

  16. NM_001402694.1 → NP_001389623.1  kinectin isoform c

    Status: REVIEWED

    Source sequence(s)
    AL138499
    Consensus CDS
    CCDS41958.1

  17. NM_001402696.1 → NP_001389625.1  kinectin isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL138499

  18. NM_001402698.1 → NP_001389627.1  kinectin isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL138499

  19. NM_001402699.1 → NP_001389628.1  kinectin isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL138499

  20. NM_001402700.1 → NP_001389629.1  kinectin isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL138499

  21. NM_001402701.1 → NP_001389630.1  kinectin isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL138499

  22. NM_001402702.1 → NP_001389631.1  kinectin isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL138499

  23. NM_001402703.1 → NP_001389632.1  kinectin isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL138499

  24. NM_001402704.1 → NP_001389633.1  kinectin isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL138499

  25. NM_001402705.1 → NP_001389634.1  kinectin isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL138499

  26. NM_001402706.1 → NP_001389635.1  kinectin isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL138499

  27. NM_001402707.1 → NP_001389636.1  kinectin isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL138499

  28. NM_001402708.1 → NP_001389637.1  kinectin isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL138499

  29. NM_001402709.1 → NP_001389638.1  kinectin isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL138499

  30. NM_001402710.1 → NP_001389639.1  kinectin isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL138499

  31. NM_001402711.1 → NP_001389640.1  kinectin isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL138499

  32. NM_004986.4 → NP_004977.2  kinectin isoform c

    See identical proteins and their annotated locations for NP_004977.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons in the coding region compared to variant 2. This variant encodes isoform c, which is shorter than isoform a.
    Source sequence(s)
    BM981127, DA769269, L25616
    Consensus CDS
    CCDS41958.1
    UniProtKB/Swiss-Prot
    Q86UP2
    Related
    ENSP00000391964.2, ENST00000438792.6
    Conserved Domains (1) summary
    COG1196
    Location:326 → 1050
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RNA

  1. NR_073128.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses two and lacks two alternate internal exons compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AY264265, BC050555, BC112337, BM981127, DA769269

  2. NR_073129.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses two alternate internal exons compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AY264265, DA769269
    Related
    ENST00000459737.5

  3. NR_175283.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL138499

  4. NR_175284.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL138499

  5. NR_175285.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL138499

  6. NR_175286.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL138499

  7. NR_175287.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL138499

  8. NR_175288.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL138499

  9. NR_175289.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL138499

  10. NR_175290.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL138499

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    55580207..55684584
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431361.1 → XP_047287317.1  kinectin isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    49785926..49890300
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054376038.1 → XP_054232013.1  kinectin isoform X1

  2. XM_054376040.1 → XP_054232015.1  kinectin isoform X6

  3. XM_054376031.1 → XP_054232006.1  kinectin isoform X2

    UniProtKB/Swiss-Prot
    B4DZ88, Q13999, Q14707, Q15387, Q17RZ5, Q5GGW3, Q86UP2, Q86W57

  4. XM_054376030.1 → XP_054232005.1  kinectin isoform X2

    UniProtKB/Swiss-Prot
    B4DZ88, Q13999, Q14707, Q15387, Q17RZ5, Q5GGW3, Q86UP2, Q86W57

  5. XM_054376034.1 → XP_054232009.1  kinectin isoform X3

  6. XM_054376039.1 → XP_054232014.1  kinectin isoform X1

  7. XM_054376029.1 → XP_054232004.1  kinectin isoform X2

    UniProtKB/Swiss-Prot
    B4DZ88, Q13999, Q14707, Q15387, Q17RZ5, Q5GGW3, Q86UP2, Q86W57

  8. XM_054376032.1 → XP_054232007.1  kinectin isoform X3

  9. XM_054376036.1 → XP_054232011.1  kinectin isoform X4

  10. XM_054376033.1 → XP_054232008.1  kinectin isoform X3

  11. XM_054376035.1 → XP_054232010.1  kinectin isoform X4

  12. XM_054376037.1 → XP_054232012.1  kinectin isoform X5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_182926.2: Suppressed sequence

    Description
    NM_182926.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86UP2.1 GenPept UniProtKB/Swiss-Prot:Q86UP2

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