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GPR153 G protein-coupled receptor 153 [ Homo sapiens (human) ]

Gene ID: 387509, updated on 5-Mar-2024

Summary

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Official Symbol
GPR153provided by HGNC
Official Full Name
G protein-coupled receptor 153provided by HGNC
Primary source
HGNC:HGNC:23618
See related
Ensembl:ENSG00000158292 MIM:614269; AllianceGenome:HGNC:23618
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR1
Summary
This gene encodes an integral membrane protein that belongs to the Class A rhodopsin superfamily of G protein coupled receptors. The encoded protein is expressed primarily in the central nervous system. A knockdown of the orthologous gene in rat is associated with a significant reduction in food intake and impaired decision making ability. Mutations in this gene are associated with schizophrenia, autism, and other neuropsychiatric disorders. The expression of this gene is activated by the glioma-associated oncogene homolog 1 transcription factor which, in turn, is activated by sonic hedgehog in normal and tumorigenic cells. [provided by RefSeq, Feb 2017]
Expression
Broad expression in colon (RPKM 6.6), fat (RPKM 4.7) and 21 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
1p36.31
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (6247353..6261098, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (5772997..5786742, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (6307413..6321158, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6296257-6297229 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6299873-6300619 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6304377-6304934 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:6305171-6305522 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 144 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 145 Neighboring gene ICMT divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 146 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6309743-6310284 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 147 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 148 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 149 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 150 Neighboring gene hes family bHLH transcription factor 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6329739-6330330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6330331-6330921 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:6333683-6333849 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6335064-6335654 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6339577-6340442 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6340686-6341235 Neighboring gene acyl-CoA thioesterase 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 76 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:6361272-6362471 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6396158-6396892 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6397980-6398642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6398643-6399303 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6399966-6400626 Neighboring gene Sharpr-MPRA regulatory region 5603 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6417160-6418127 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 77 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 78 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 79 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 80 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6424607-6425106 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6427779-6428559 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6434479-6434978 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6445825-6446810 Neighboring gene H3K27ac hESC enhancers GRCh37_chr1:6453176-6453687 and GRCh37_chr1:6453688-6454200 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:6454201-6454711 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6455464-6455988 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:6474153-6474654 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:6474655-6475154 Neighboring gene hes family bHLH transcription factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The role of G protein-coupled receptors in the early evolution of neurotransmission and the nervous system. Krishnan A, et al. J Exp Biol, 2015 Feb 15. PMID 25696819
  2. De novo variants in sporadic cases of childhood onset schizophrenia. Ambalavanan A, et al. Eur J Hum Genet, 2016 Jun. PMID 26508570, Free PMC Article
  3. The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus, cerebellum and the arcuate nucleus. Sreedharan S, et al. FEBS J, 2011 Dec. PMID 21981325
  4. Sequence-structure based phylogeny of GPCR Class A Rhodopsin receptors. Kakarala KK, et al. Mol Phylogenet Evol, 2014 May. PMID 24503482
  5. Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. Gloriam DE, et al. Biochim Biophys Acta, 2005 Apr 15. PMID 15777626

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp762B2210

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 153
Names
G-protein coupled receptor PGR1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053044.1 RefSeqGene

    Range
    4893..18638
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_207370.4 → NP_997253.2  probable G-protein coupled receptor 153

    See identical proteins and their annotated locations for NP_997253.2

    Status: REVIEWED

    Source sequence(s)
    AL031847, BC068275, BQ575651
    Consensus CDS
    CCDS64.1
    UniProtKB/Swiss-Prot
    Q5TGR5, Q6AHW8, Q6NV75, Q86SP8
    UniProtKB/TrEMBL
    A0A0I9QQ03
    Related
    ENSP00000367125.2, ENST00000377893.3
    Conserved Domains (1) summary
    pfam00001
    Location:29 → 219
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    6247353..6261098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541434.4 → XP_011539736.1  probable G-protein coupled receptor 153 isoform X1

    See identical proteins and their annotated locations for XP_011539736.1

    UniProtKB/Swiss-Prot
    Q5TGR5, Q6AHW8, Q6NV75, Q86SP8
    UniProtKB/TrEMBL
    A0A0I9QQ03
    Conserved Domains (1) summary
    pfam00001
    Location:29 → 219
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  2. XM_017001250.2 → XP_016856739.1  probable G-protein coupled receptor 153 isoform X1

    UniProtKB/Swiss-Prot
    Q5TGR5, Q6AHW8, Q6NV75, Q86SP8
    UniProtKB/TrEMBL
    A0A0I9QQ03
    Conserved Domains (1) summary
    pfam00001
    Location:29 → 219
    7tm_1; 7 transmembrane receptor (rhodopsin family)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    5772997..5786742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336486.1 → XP_054192461.1  probable G-protein coupled receptor 153 isoform X1

    UniProtKB/Swiss-Prot
    Q5TGR5, Q6AHW8, Q6NV75, Q86SP8
    UniProtKB/TrEMBL
    A0A0I9QQ03

  2. XM_054336485.1 → XP_054192460.1  probable G-protein coupled receptor 153 isoform X1

    UniProtKB/Swiss-Prot
    Q5TGR5, Q6AHW8, Q6NV75, Q86SP8
    UniProtKB/TrEMBL
    A0A0I9QQ03
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NV75.2 GenPept UniProtKB/Swiss-Prot:Q6NV75

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