ple pale [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: pleprovided by FlyBase
Official Full Name: paleprovided by FlyBase
Primary source: FLYBASE:FBgn0005626
Locus tag: Dmel_CG10118
See related: AllianceGenome:FB:FBgn0005626
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10118; DH65B; Dmel\CG10118; DTH; dTH1; dTH65B; Pale; pale/ple; Ple; th; Th; TH; TyrH; VII
Summary: Predicted to enable tyrosine 3-monooxygenase activity. Involved in several processes, including adult chitin-containing cuticle pigmentation; regulation of epithelial cell migration, open tracheal system; and thermosensory behavior. Predicted to be active in axon; cytoplasm; and perikaryon. Is expressed in several structures, including adult brain; presumptive embryonic/larval system; serotonergic neurons; supraesophageal ganglion; and thoracic neurons. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinsonism; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 65C3-65C3; 3-17 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (6713356..6719525, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (6706456..6712625, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of Plasma Membrane Ca[2+] ATPase driven by tyrosine hydroxylase-Gal4 reduces Drosophila lifespan independently of effects in neurons.
Title: Downregulation of Plasma Membrane Ca(2+) ATPase driven by tyrosine hydroxylase-Gal4 reduces Drosophila lifespan independently of effects in neurons.
activity of tyrosine hydroxylase is also increased by this interaction, in excess of the stimulation resulting from phosphorylation alone
Title: Direct binding of GTP cyclohydrolase and tyrosine hydroxylase: regulatory interactions between key enzymes in dopamine biosynthesis.
The biochemically conserved regulatory mechanisms of recombinant DTH parallel those from mammals.
Title: Biochemical conservation of recombinant Drosophila tyrosine hydroxylase with its mammalian cognates.
maternal as well as embryonic effects on the secretion and/or functionality of Tyrosine hydroxylase (pale) may play roles in the early developmental program of the organism.
Title: Maternal and embryonic sources of tyrosine hydroxylase during Drosophila embryogenesis.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info
enables tyrosine 3-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tyrosine 3-monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables tyrosine 3-monooxygenase activity	NAS Non-traceable Author Statement more info	PubMed
enables tyrosine 3-monooxygenase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in adult chitin-containing cuticle pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in aromatic amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in catecholamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in catecholamine metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in courtship behavior	NAS Non-traceable Author Statement more info	PubMed
involved_in cuticle pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in developmental pigmentation	TAS Traceable Author Statement more info	PubMed
involved_in dopamine biosynthetic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in dopamine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dopamine biosynthetic process from tyrosine	IBA Inferred from Biological aspect of Ancestor more info
involved_in dopamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of adult chitin-containing cuticle pigmentation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of adult chitin-containing cuticle pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of epithelial cell migration, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to wounding	IEP Inferred from Expression Pattern more info	PubMed
involved_in thermosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thermotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wing disc development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in perikaryon	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: pale

Names: CG10118-PA; CG10118-PB; CG10118-PC; Tyrosine-3-hydroxylase; XBB70 group VII; drosophila tyrosine hydroxylase; ple-PA; ple-PB; ple-PC; tyrosine 3-monooxygenase; tyrosine hydrodroxylase; tyrosine hydroxylase; tyrosine-hydroxylase; tyrosone hydroxylase

NP_001286955.1

EC 1.14.16.-

EC 1.14.16.2

NP_476897.1

EC 1.14.16.-

EC 1.14.16.2

NP_476898.1

EC 1.14.16.-

EC 1.14.16.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

6713356..6719525 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300026.1 → NP_001286955.1 pale, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286955.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P18459, Q24000, Q8SY95

UniProtKB/TrEMBL

B5X0J4

Conserved Domains (1) summary

TIGR01269
Location:130 → 576

Tyr_3_monoox; tyrosine 3-monooxygenase, tetrameric
NM_057549.3 → NP_476897.1 pale, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476897.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P18459

Related

FBpp0076665

Conserved Domains (3) summary

TIGR01269
Location:48 → 505

Tyr_3_monoox; tyrosine 3-monooxygenase, tetrameric

cd04930
Location:48 → 163

ACT_TH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tyrosine hydroxylases (TH)

pfam00351
Location:172 → 502

Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
NM_057550.4 → NP_476898.1 pale, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476898.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P18459, Q24000, Q8SY95

UniProtKB/TrEMBL

B5X0J4

Related

FBpp0076666

Conserved Domains (1) summary

TIGR01269
Location:130 → 576

Tyr_3_monoox; tyrosine 3-monooxygenase, tetrameric