U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PAX5 paired box 5 [ Gallus gallus (chicken) ]

Gene ID: 387330, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Symbol
PAX5provided by CGNC
Full Name
paired box 5provided by CGNC
Primary source
CGNC:49160
See related
Ensembl:ENSGALG00010001212
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
Pax5B
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: Z
Exon count:
11
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (85810944..85926014)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (85810944..85926014)

Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124417501 Neighboring gene zinc finger CCHC-type containing 7 Neighboring gene uncharacterized LOC112530592 Neighboring gene rho GTPase-activating protein 32-like Neighboring gene maternal embryonic leucine zipper kinase

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Locus-specific ChIP combined with NGS analysis reveals genomic regulatory regions that physically interact with the Pax5 promoter in a chicken B cell line. Fujita T, et al. DNA Res, 2017 Oct 1. PMID 28586432, Free PMC Article
  2. Paired box gene 5 isoforms A and B have different functions in transcriptional regulation of B cell development-related genes in immature B cells. Kikuchi H, et al. Microbiol Immunol, 2015 Jul. PMID 26094714
  3. Species-specific 5'-genomic structure and multiple transcription start sites in the chicken Pax5 gene. Fujita T, et al. Gene, 2011 May 15. PMID 21241785
  4. Role of Pax-5 in the regulation of a mid-hindbrain organizer's activity. Funahashi J, et al. Dev Growth Differ, 1999 Feb. PMID 10445503
  5. A critical role of the Thy28-MYH9 axis in B cell-specific expression of the Pax5 gene in chicken B cells. Fujita T, et al. PLoS One, 2015. PMID 25607658, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pax5 transcription in DT40 is regulated by B cell-specific inter-chromosomal interactions.
    Title: Locus-specific ChIP combined with NGS analysis reveals genomic regulatory regions that physically interact with the Pax5 promoter in a chicken B cell line.
  2. Pax5A, Pax5B exhibit distinct roles in transcriptional regulation of six B cell development-related genes.
    Title: Paired box gene 5 isoforms A and B have different functions in transcriptional regulation of B cell development-related genes in immature B cells.
  3. Data indicates that Thy28 is functionally required for B cell-specific expression of Pax5 via recruitment of MYH9 to the Pax5 locus in chicken B cells.
    Title: A critical role of the Thy28-MYH9 axis in B cell-specific expression of the Pax5 gene in chicken B cells.
  4. Data show that the exons 1A and 1B had one and three major transcription start sites, respectively.
    Title: Species-specific 5'-genomic structure and multiple transcription start sites in the chicken Pax5 gene.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in anatomical structure development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
paired box protein Pax-5
Names
Pax5B with a deletion of exon 8 protein
paired box gene 5 (B-cell lineage specific activator)
paired box protein Pax-5A
paired box protein Pax-5B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001397563.1 → NP_001384492.1  paired box protein Pax-5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000211
    UniProtKB/TrEMBL
    A0A0C6E619
    Related
    ENSGALP00010001352.1, ENSGALT00010002802.1
    Conserved Domains (2) summary
    smart00351
    Location:15 → 139
    PAX; Paired Box domain
    pfam12403
    Location:278 → 354
    Pax2_C; Paired-box protein 2 C terminal

  2. NM_204424.2 → NP_989755.1  paired box protein Pax-5 isoform 1

    See identical proteins and their annotated locations for NP_989755.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000211
    UniProtKB/TrEMBL
    A0A8V0XA07, Q9W601
    Related
    ENSGALP00010001353.1, ENSGALT00010002803.1
    Conserved Domains (2) summary
    smart00351
    Location:16 → 140
    PAX; Paired Box domain
    pfam12403
    Location:285 → 389
    Pax2_C; Paired-box protein 2 C terminal

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    85810944..85926014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025144634.3 → XP_025000402.1  paired box protein Pax-5 isoform X2

    UniProtKB/TrEMBL
    A0A8V0X7D3
    Conserved Domains (2) summary
    smart00351
    Location:16 → 140
    PAX; Paired Box domain
    pfam12403
    Location:294 → 355
    Pax2_C; Paired-box protein 2 C terminal

  2. XM_015280784.4 → XP_015136270.1  paired box protein Pax-5 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XA07, F1NKV2
    Related
    ENSGALP00010001351.1, ENSGALT00010002801.1
    Conserved Domains (2) summary
    smart00351
    Location:15 → 139
    PAX; Paired Box domain
    pfam12403
    Location:284 → 388
    Pax2_C; Paired-box protein 2 C terminal

  3. XM_025144636.3 → XP_025000404.1  paired box protein Pax-5 isoform X3

    Conserved Domains (2) summary
    pfam12403
    Location:177 → 281
    Pax2_C; Paired-box protein 2 C terminal
    cl21459
    Location:1 → 34
    HTH; Helix-turn-helix domains

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    85810944..85926014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046934663.1 → XP_046790619.1  paired box protein Pax-5 isoform X2

  2. XM_046934662.1 → XP_046790618.1  paired box protein Pax-5 isoform X1

    UniProtKB/TrEMBL
    F1NKV2

  3. XM_046934664.1 → XP_046790620.1  paired box protein Pax-5 isoform X3

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.