cstf2 cleavage stimulation factor, 3' pre-RNA, subunit 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cstf2provided by ZNC
Official Full Name: cleavage stimulation factor, 3' pre-RNA, subunit 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-031118-2
See related: Ensembl:ENSDARG00000090788 AllianceGenome:ZFIN:ZDB-GENE-031118-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: CstF-64; fb11e07; zgc:56346; zgc:77730; wu:fb11e07
Summary: Predicted to enable mRNA binding activity. Predicted to be involved in pre-mRNA cleavage required for polyadenylation. Predicted to act upstream of or within mRNA polyadenylation. Predicted to be located in nucleus. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to several human genes including CSTF2 (cleavage stimulation factor subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (41361858..41388180, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (40994604..41020924, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within mRNA 3'-end processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of mRNA cleavage and polyadenylation specificity factor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cleavage stimulation factor subunit 2

Names: cleavage stimulation factor 64 kilodalton subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200114.2 → NP_956408.2 cleavage stimulation factor subunit 2

See identical proteins and their annotated locations for NP_956408.2

Status: PROVISIONAL

Source sequence(s)

BC065442

UniProtKB/TrEMBL

Q6P0U7

Related

ENSDARP00000110939.1, ENSDART00000124532.4

Conserved Domains (5) summary

PHA03195
Location:273 → 339

PHA03195; tegument protein VP11/12; Provisional

COG0724
Location:24 → 112

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12671
Location:26 → 100

RRM_CSTF2_CSTF2T; RNA recognition motif in cleavage stimulation factor subunit 2 (CSTF2), cleavage stimulation factor subunit 2 tau variant (CSTF2T) and similar proteins

pfam14304
Location:444 → 484

CSTF_C; Transcription termination and cleavage factor C-terminal

pfam14327
Location:121 → 199

CSTF2_hinge; Hinge domain of cleavage stimulation factor subunit 2

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

41361858..41388180 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009291098.3 → XP_009289373.1 cleavage stimulation factor subunit 2 isoform X1

UniProtKB/TrEMBL

A0A0R4I9I2, A0A8M3AHX3

Related

ENSDARP00000129952.1, ENSDART00000169247.2

Conserved Domains (4) summary

COG0724
Location:24 → 112

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12671
Location:26 → 100

RRM_CSTF2_CSTF2T; RNA recognition motif in cleavage stimulation factor subunit 2 (CSTF2), cleavage stimulation factor subunit 2 tau variant (CSTF2T) and similar proteins

pfam14304
Location:464 → 504

CSTF_C; Transcription termination and cleavage factor C-terminal

pfam14327
Location:121 → 199

CSTF2_hinge; Hinge domain of cleavage stimulation factor subunit 2