itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: itga5provided by ZNC
Official Full Name: integrin, alpha 5 (fibronectin receptor, alpha polypeptide)provided by ZNC
Primary source: ZFIN:ZDB-GENE-031116-52
See related: Ensembl:ENSDARG00000006353 AllianceGenome:ZFIN:ZDB-GENE-031116-52
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sb:cb665; wu:fe02h07
Summary: Enables fibronectin binding activity and protein heterodimerization activity. Acts upstream of or within several processes, including camera-type eye development; cell migration involved in sprouting angiogenesis; and chordate embryonic development. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of integrin complex. Is expressed in several structures, including cardiovascular system; ectoderm; head; mesoderm; and somite. Orthologous to human ITGA5 (integrin subunit alpha 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (33447625..33558158, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (33521094..33631627, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Integrin alpha5 and Integrin alpha4 cooperate to promote endocardial differentiation and heart morphogenesis.
Title: Integrin α5 and Integrin α4 cooperate to promote endocardial differentiation and heart morphogenesis.
Injection of alpha5beta1 protein rescued the Fibronectin layer and then the myocardial precursor migration in snai1b knockdown embryos.
Title: Snail modulates the assembly of fibronectin via α5 integrin for myocardial migration in zebrafish embryos.
Data indicate that focal adhesion kinase (FAK) activity may be a mediator of the integrin alpha5/Fn1 interaction during zebrafish lens fiber morphogenesis.
Title: Integrin α5/fibronectin1 and focal adhesion kinase are required for lens fiber morphogenesis in zebrafish.
itga5 coordinates cell migration into posterior placodes and augments Fgf signaling required for patterning of these tissues and cell survival in otic/epibranchial placodes
Title: Integrin-α5 coordinates assembly of posterior cranial placodes in zebrafish and enhances Fgf-dependent regulation of otic/epibranchial cells.
Zebrafish alpha5beta1 integrins do bind zebrafish fibronectin-1
Title: Mapping the ligand-binding pocket of integrin alpha5beta1 using a gain-of-function approach.
Data suggest that incipient integrin alpha5beta1 clustering along the nascent border precedes matrix formation and is independent of fibronectin binding.
Title: Control of extracellular matrix assembly along tissue boundaries via Integrin and Eph/Ephrin signaling.
Data suggest that delta/notch- and integrinalpha5-dependent cell polarization and fibronectin matrix assembly occur concomitantly and interdependently during border morphogenesis.
Title: Integrinalpha5 and delta/notch signaling have complementary spatiotemporal requirements during zebrafish somitogenesis.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables fibronectin binding	IGI Inferred from Genetic Interaction more info	PubMed
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adrenal gland development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axis elongation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within axis elongation involved in somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cartilage development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cartilage development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration involved in sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocardial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endoderm formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within endoderm formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within extracellular matrix assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lens fiber cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lens morphogenesis in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pharyngeal system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pharyngeal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somite rostral/caudal axis specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somitogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vasculature development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: integrin alpha-5

Names: fibronectin receptor alpha subunit; integrin alpha5; polypterus

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004288.2 → NP_001004288.2 integrin alpha-5 precursor

See identical proteins and their annotated locations for NP_001004288.2

Status: VALIDATED

Source sequence(s)

AY550244, CR293512, EB775387

UniProtKB/TrEMBL

A0A8M1N239, Q5I2A9, Q6QAF3

Related

ENSDARP00000027718.9, ENSDART00000018301.11

Conserved Domains (3) summary

smart00191
Location:375 → 430

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:479 → 926

Integrin_alpha2; Integrin alpha

pfam13517
Location:269 → 332

VCBS; Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella