tlc secreted frizzled-related protein [Danio rerio (zebrafish)] - Gene

Summary

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Official Symbol: tlcprovided by ZNC
Official Full Name: secreted frizzled-related proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031020-1
See related: AllianceGenome:ZFIN:ZDB-GENE-031020-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sfrp
Summary: Predicted to act upstream of or within Wnt signaling pathway; cell differentiation; and regulation of signal transduction. Predicted to be located in extracellular region. Is expressed in forebrain neural plate; neural keel; and neural plate. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: not in current annotation release
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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cloning of full-length cDNA for sfrp1a, sfrp1b, sfrp2, sfrp3 and sfrp5 gene transcripts and their expression at different embryonic stages.
Title: Cloning and embryonic expression of five distinct sfrp genes in the zebrafish Danio rerio.

Submit: New GeneRIF Correction

General protein information

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Preferred Names: secreted frizzled-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198362.1 → NP_938176.1 secreted frizzled-related protein precursor

See identical proteins and their annotated locations for NP_938176.1

Status: PROVISIONAL

Source sequence(s)

AF520426

UniProtKB/TrEMBL

Q8JHC7

Conserved Domains (2) summary

cd07453
Location:26 → 162

CRD_crescent; Cysteine-rich domain of the crescent protein

cd03580
Location:154 → 278

NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...