PolE2 DNA polymerase epsilon subunit 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PolE2provided by FlyBase
Official Full Name: DNA polymerase epsilon subunit 2provided by FlyBase
Primary source: FLYBASE:FBgn0035644
Locus tag: Dmel_CG10489
See related: AllianceGenome:FB:FBgn0035644
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 10489; CG10489; Dmel\CG10489; DNApol-epsilon; DNApol-epsilon58; dpolepsilonp58; pol.epsilon 2; Pole2; POLE2
Summary: Predicted to enable DNA binding activity. Involved in DNA-dependent DNA replication and positive regulation of DNA endoreduplication. Part of epsilon DNA polymerase complex. Orthologous to human POLE2 (DNA polymerase epsilon 2, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (5895691..5897435, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (5888791..5890535, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication proofreading	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA-templated DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA-templated DNA replication	IEA Inferred from Electronic Annotation more info
involved_in error-prone translesion synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell cycle process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of epsilon DNA polymerase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of epsilon DNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of epsilon DNA polymerase complex	IPI Inferred from Physical Interaction more info	PubMed

Names: CG10489-PA; DNA polymerase epsilon 58kD subunit; DNA polymerase epsilon B subunit; PolE2-PA; Pole2

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