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NR2F2 nuclear receptor subfamily 2 group F member 2 [ Gallus gallus (chicken) ]

Gene ID: 386585, updated on 3-Apr-2024

Summary

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Symbol
NR2F2provided by CGNC
Full Name
nuclear receptor subfamily 2 group F member 2provided by CGNC
Primary source
CGNC:49158
See related
Ensembl:ENSGALG00010016558
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
TFCOUP2; COUP-TFII
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 10
Exon count:
5
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 10 NC_052541.1 (15843935..15856264)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 10 NC_052582.1 (15715496..15727815)

Chromosome 10 - NC_052541.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101748407 Neighboring gene uncharacterized LOC121111590 Neighboring gene uncharacterized LOC107054251 Neighboring gene uncharacterized LOC101748621 Neighboring gene microRNA 1680

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Developmental regulation of the orphan receptor COUP-TF II gene in spinal motor neurons. Lutz B, et al. Development, 1994 Jan. PMID 8119130
  2. Endoglin inhibition leads to intussusceptive angiogenesis via activation of factors related to COUP-TFII signaling pathway. Hlushchuk R, et al. PLoS One, 2017. PMID 28859090, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In this study, we have shown that ENG inhibition and at the same time up-regulation of COUP-TFII expression promotes intussusceptive angiogenesis.
    Title: Endoglin inhibition leads to intussusceptive angiogenesis via activation of factors related to COUP-TFII signaling pathway.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables retinoic acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in anatomical structure development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
COUP transcription factor 2
Names
COUP transcription factor II
COUP-TF II
COUP-TF2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001396109.1 → NP_001383038.1  COUP transcription factor 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000245
    UniProtKB/TrEMBL
    A0A3Q2UN56, A0A8V0YQ04
    Related
    ENSGALP00010023089.1, ENSGALT00010039888.1
    Conserved Domains (1) summary
    cd06948
    Location:44 → 279
    NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family

  2. NM_204421.2 → NP_989752.1  COUP transcription factor 2 isoform 1

    See identical proteins and their annotated locations for NP_989752.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000245
    UniProtKB/Swiss-Prot
    Q90733
    Conserved Domains (2) summary
    cd06948
    Location:173 → 408
    NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
    cd06958
    Location:75 → 147
    NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052541.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    15843935..15856264
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046898877.1 → XP_046754833.1  COUP transcription factor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YWC8
    Related
    ENSGALP00010023081.1, ENSGALT00010039879.1

  2. XM_046898878.1 → XP_046754834.1  COUP transcription factor 2 isoform X2

  3. XM_046898879.1 → XP_046754835.1  COUP transcription factor 2 isoform X2

  4. XM_046898881.1 → XP_046754837.1  COUP transcription factor 2 isoform X2

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052582.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    15715496..15727815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046924463.1 → XP_046780419.1  COUP transcription factor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YWC8

  2. XM_046924464.1 → XP_046780420.1  COUP transcription factor 2 isoform X2

  3. XM_046924465.1 → XP_046780421.1  COUP transcription factor 2 isoform X2

  4. XM_046924466.1 → XP_046780422.1  COUP transcription factor 2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q90733.1 GenPept UniProtKB/Swiss-Prot:Q90733

Gene LinkOut

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