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PTPRC protein tyrosine phosphatase, receptor type C [ Gallus gallus (chicken) ]

Gene ID: 386580, updated on 3-Apr-2024

Summary

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Symbol
PTPRCprovided by CGNC
Full Name
protein tyrosine phosphatase, receptor type Cprovided by CGNC
Primary source
CGNC:1563
See related
Ensembl:ENSGALG00010012352
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 8
Exon count:
43
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 8 NC_052539.1 (2035004..2116225, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 8 NC_052580.1 (2048221..2130650, complement)

Chromosome 8 - NC_052539.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107053920 Neighboring gene uncharacterized LOC121113415 Neighboring gene microRNA 181a-1 Neighboring gene microRNA 181b-1 Neighboring gene uncharacterized LOC107053922 Neighboring gene ATPase H+ transporting V1 subunit G3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A transmembrane protein-tyrosine phosphatase contains spectrin-like repeats in its extracellular domain. Fang KS, et al. J Biol Chem, 1994 May 13. PMID 8188686
  2. Structural and functional analysis of the human CD45 gene (PTPRC) upstream region: evidence for a functional promoter within the first intron of the gene. Timón M, et al. Immunology, 2001 Feb. PMID 11260323, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
receptor-type tyrosine-protein phosphatase C
Names
leukocyte common antigen, CD45
NP_989748.3
XP_015145719.2
XP_015145720.2
XP_015145722.2
XP_015145723.2
XP_015145724.2
XP_015145725.2
XP_025008503.2
XP_025008506.2
XP_025008508.2
XP_025008509.2
XP_025008510.2
XP_046778204.1
XP_046778205.1
XP_046778206.1
XP_046778207.1
XP_046778208.1
XP_046778210.1
XP_046778211.1
XP_046778212.1
XP_046778213.1
XP_046778214.1
XP_046778215.1
XP_046778216.1
XP_046778217.1
XP_046778218.1
XP_046778219.1
XP_046778221.1
XP_046778222.1
XP_046778223.1
XP_046778224.1
XP_046778225.1
XP_046778226.1
XP_046778227.1
XP_046800185.1
XP_046800186.1
XP_046800187.1
XP_046800188.1
XP_046800189.1
XP_046800191.1
XP_046800192.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204417.3 → NP_989748.3  receptor-type tyrosine-protein phosphatase C precursor

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000237
    UniProtKB/TrEMBL
    A0A8V0Y943, A0A8V0YFC8
    Related
    ENSGALP00010017217.1, ENSGALT00010029596.1
    Conserved Domains (3) summary
    cd00063
    Location:323 → 392
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14557
    Location:640 → 840
    R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
    cd14558
    Location:950 → 1156
    R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052539.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    2035004..2116225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046944231.1 → XP_046800187.1  receptor-type tyrosine-protein phosphatase C isoform X1

    UniProtKB/TrEMBL
    A0A8V0YFC8

  2. XM_046944230.1 → XP_046800186.1  receptor-type tyrosine-protein phosphatase C isoform X1

    UniProtKB/TrEMBL
    A0A8V0YFC8

  3. XM_046944236.1 → XP_046800192.1  receptor-type tyrosine-protein phosphatase C isoform X4

    UniProtKB/TrEMBL
    A0A8V0YM93

  4. XM_025152740.3 → XP_025008508.2  receptor-type tyrosine-protein phosphatase C isoform X5

    UniProtKB/TrEMBL
    A0A8V0YFA6
    Conserved Domains (3) summary
    cd00063
    Location:288 → 357
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14557
    Location:605 → 805
    R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
    cd14558
    Location:915 → 1121
    R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2

  5. XM_015290233.4 → XP_015145719.2  receptor-type tyrosine-protein phosphatase C isoform X1

    UniProtKB/TrEMBL
    A0A8V0Y943, A0A8V0YFC8
    Conserved Domains (3) summary
    cd00063
    Location:323 → 392
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14557
    Location:640 → 840
    R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
    cd14558
    Location:950 → 1156
    R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2

  6. XM_046944233.1 → XP_046800189.1  receptor-type tyrosine-protein phosphatase C isoform X3

  7. XM_046944232.1 → XP_046800188.1  receptor-type tyrosine-protein phosphatase C isoform X1

    UniProtKB/TrEMBL
    A0A8V0YFC8

  8. XM_046944229.1 → XP_046800185.1  receptor-type tyrosine-protein phosphatase C isoform X1

    UniProtKB/TrEMBL
    A0A8V0YFC8

  9. XM_015290239.4 → XP_015145725.2  receptor-type tyrosine-protein phosphatase C isoform X11

    UniProtKB/TrEMBL
    A0A8V0Y930
    Related
    ENSGALP00010017203.1, ENSGALT00010029580.1
    Conserved Domains (3) summary
    cd00063
    Location:216 → 285
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14557
    Location:533 → 733
    R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
    cd14558
    Location:843 → 1049
    R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2

  10. XM_015290238.4 → XP_015145724.2  receptor-type tyrosine-protein phosphatase C isoform X10

    UniProtKB/TrEMBL
    A0A8V0YHG4
    Related
    ENSGALP00010017213.1, ENSGALT00010029592.1
    Conserved Domains (3) summary
    cd00063
    Location:245 → 314
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14557
    Location:562 → 762
    R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
    cd14558
    Location:872 → 1078
    R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2

  11. XM_015290234.4 → XP_015145720.2  receptor-type tyrosine-protein phosphatase C isoform X4

    UniProtKB/TrEMBL
    A0A8V0YHG4, A0A8V0YM93
    Related
    ENSGALP00010017216.1, ENSGALT00010029595.1
    Conserved Domains (3) summary
    cd00063
    Location:291 → 360
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14557
    Location:608 → 808
    R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
    cd14558
    Location:918 → 1124
    R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2

  12. XM_025152738.3 → XP_025008506.2  receptor-type tyrosine-protein phosphatase C isoform X5

    UniProtKB/TrEMBL
    A0A8V0YFA6
    Conserved Domains (3) summary
    cd00063
    Location:288 → 357
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14557
    Location:605 → 805
    R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
    cd14558
    Location:915 → 1121
    R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2

  13. XM_025152742.3 → XP_025008510.2  receptor-type tyrosine-protein phosphatase C isoform X9

    UniProtKB/TrEMBL
    A0A8V0Y930
    Conserved Domains (3) summary
    cd00063
    Location:247 → 316
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14557
    Location:564 → 764
    R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
    cd14558
    Location:874 → 1080
    R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2

  14. XM_025152741.3 → XP_025008509.2  receptor-type tyrosine-protein phosphatase C isoform X7

    UniProtKB/TrEMBL
    A0A8V0YHG4
    Conserved Domains (3) summary
    cd00063
    Location:276 → 345
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14557
    Location:593 → 793
    R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
    cd14558
    Location:903 → 1109
    R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2

  15. XM_025152735.3 → XP_025008503.2  receptor-type tyrosine-protein phosphatase C isoform X2

    UniProtKB/TrEMBL
    A0A8V0Y943
    Conserved Domains (3) summary
    cd00063
    Location:322 → 391
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14557
    Location:639 → 839
    R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
    cd14558
    Location:949 → 1155
    R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2

  16. XM_015290237.4 → XP_015145723.2  receptor-type tyrosine-protein phosphatase C isoform X8

    UniProtKB/TrEMBL
    A0A8V0Y930
    Related
    ENSGALP00010017200.1, ENSGALT00010029577.1
    Conserved Domains (3) summary
    cd00063
    Location:248 → 317
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14557
    Location:565 → 765
    R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
    cd14558
    Location:875 → 1081
    R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2

  17. XM_015290236.4 → XP_015145722.2  receptor-type tyrosine-protein phosphatase C isoform X6

    UniProtKB/TrEMBL
    A0A8V0YHG4
    Conserved Domains (3) summary
    cd00063
    Location:277 → 346
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14557
    Location:594 → 794
    R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
    cd14558
    Location:904 → 1110
    R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2

  18. XM_046944235.1 → XP_046800191.1  receptor-type tyrosine-protein phosphatase C isoform X3

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052580.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    2048221..2130650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046922252.1 → XP_046778208.1  receptor-type tyrosine-protein phosphatase C isoform X1

  2. XM_046922251.1 → XP_046778207.1  receptor-type tyrosine-protein phosphatase C isoform X1

  3. XM_046922250.1 → XP_046778206.1  receptor-type tyrosine-protein phosphatase C isoform X1

  4. XM_046922260.1 → XP_046778216.1  receptor-type tyrosine-protein phosphatase C isoform X4

  5. XM_046922263.1 → XP_046778219.1  receptor-type tyrosine-protein phosphatase C isoform X5

  6. XM_046922248.1 → XP_046778204.1  receptor-type tyrosine-protein phosphatase C isoform X1

  7. XM_046922256.1 → XP_046778212.1  receptor-type tyrosine-protein phosphatase C isoform X3

  8. XM_046922254.1 → XP_046778210.1  receptor-type tyrosine-protein phosphatase C isoform X1

  9. XM_046922249.1 → XP_046778205.1  receptor-type tyrosine-protein phosphatase C isoform X1

  10. XM_046922271.1 → XP_046778227.1  receptor-type tyrosine-protein phosphatase C isoform X11

  11. XM_046922270.1 → XP_046778226.1  receptor-type tyrosine-protein phosphatase C isoform X10

  12. XM_046922259.1 → XP_046778215.1  receptor-type tyrosine-protein phosphatase C isoform X4

  13. XM_046922262.1 → XP_046778218.1  receptor-type tyrosine-protein phosphatase C isoform X5

  14. XM_046922269.1 → XP_046778225.1  receptor-type tyrosine-protein phosphatase C isoform X9

  15. XM_046922267.1 → XP_046778223.1  receptor-type tyrosine-protein phosphatase C isoform X7

  16. XM_046922255.1 → XP_046778211.1  receptor-type tyrosine-protein phosphatase C isoform X2

  17. XM_046922268.1 → XP_046778224.1  receptor-type tyrosine-protein phosphatase C isoform X8

  18. XM_046922266.1 → XP_046778222.1  receptor-type tyrosine-protein phosphatase C isoform X6

  19. XM_046922258.1 → XP_046778214.1  receptor-type tyrosine-protein phosphatase C isoform X3

  20. XM_046922261.1 → XP_046778217.1  receptor-type tyrosine-protein phosphatase C isoform X4

  21. XM_046922265.1 → XP_046778221.1  receptor-type tyrosine-protein phosphatase C isoform X5

  22. XM_046922257.1 → XP_046778213.1  receptor-type tyrosine-protein phosphatase C isoform X3

Nucleotide Protein
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