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RPS6KA1 ribosomal protein S6 kinase A1 [ Gallus gallus (chicken) ]

Gene ID: 386579, updated on 3-Apr-2024

Summary

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Symbol
RPS6KA1provided by CGNC
Full Name
ribosomal protein S6 kinase A1provided by CGNC
Primary source
CGNC:212
See related
Ensembl:ENSGALG00010014470
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
RSK; RPS6KA; RPS6KA1L
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 23
Exon count:
28
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 23 NC_052554.1 (492114..520636, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 23 NC_052595.1 (258733..287255, complement)

Chromosome 23 - NC_052554.1Genomic Context describing neighboring genes Neighboring gene AT-rich interaction domain 1A Neighboring gene uncharacterized LOC121107494 Neighboring gene high mobility group nucleosomal binding domain 4 Neighboring gene dehydrodolichyl diphosphate synthase subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence and expression of chicken and mouse rsk: homologs of Xenopus laevis ribosomal S6 kinase. Alcorta DA, et al. Mol Cell Biol, 1989 Sep. PMID 2779569, Free PMC Article
  2. The p90 ribosomal S6 kinase-UBR5 pathway controls Toll-like receptor signaling via miRNA-induced translational inhibition of tumor necrosis factor receptor-associated factor 3. Cho JH, et al. J Biol Chem, 2017 Jul 14. PMID 28559278, Free PMC Article
  3. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ribosomal protein S6 kinase 2 alpha
Names
MAP kinase-activated protein kinase 1
MAPK-activated protein kinase 1
MAPKAP kinase 1
MAPKAPK-1
S6KII-alpha
p90-RSK
ribosomal protein S6 kinase II alpha
ribosomal protein S6 kinase, 90kDa, polypeptide 1
NP_001103241.1
XP_015152999.1
XP_015153000.1
XP_015153001.1
XP_015153002.1
XP_015153003.1
XP_015153004.1
XP_040507563.1
XP_040507564.1
XP_046759456.1
XP_046759457.1
XP_046759458.1
XP_046759460.1
XP_046759461.1
XP_046759462.1
XP_046759463.1
XP_046787763.1
XP_046787764.1
XP_046787765.1
XP_046787766.1
XP_046787767.1
XP_046787768.1
XP_046787769.1
XP_046787770.1
XP_046787771.1
XP_046787772.1
XP_046787773.1
XP_046787774.1
XP_046787775.1
XP_046787776.1
XP_046787777.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109771.3 → NP_001103241.1  ribosomal protein S6 kinase 2 alpha

    See identical proteins and their annotated locations for NP_001103241.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000339
    UniProtKB/Swiss-Prot
    P18652
    UniProtKB/TrEMBL
    A0A8V0YP12
    Related
    ENSGALP00010020406.1, ENSGALT00010034833.1
    Conserved Domains (2) summary
    cd05582
    Location:84 → 400
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14175
    Location:433 → 723
    STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052554.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    492114..520636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015297514.4 → XP_015153000.1  ribosomal protein S6 kinase 2 alpha isoform X3

    UniProtKB/TrEMBL
    A0A3Q3ADZ8, A0A8V0YVW3
    Related
    ENSGALP00010020404.1, ENSGALT00010034824.1
    Conserved Domains (4) summary
    smart00220
    Location:65 → 323
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:69 → 385
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14175
    Location:418 → 708
    STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)
    pfam00069
    Location:420 → 677
    Pkinase; Protein kinase domain

  2. XM_015297515.4 → XP_015153001.1  ribosomal protein S6 kinase 2 alpha isoform X4

    UniProtKB/TrEMBL
    A0A8V0YQT6, A0A8V0YVW3
    Related
    ENSGALP00010020399.1, ENSGALT00010034813.1
    Conserved Domains (4) summary
    smart00220
    Location:62 → 320
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:66 → 382
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14175
    Location:415 → 705
    STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)
    pfam00069
    Location:417 → 674
    Pkinase; Protein kinase domain

  3. XM_046903500.1 → XP_046759456.1  ribosomal protein S6 kinase 2 alpha isoform X1

    UniProtKB/TrEMBL
    A0A8V0YVU9
    Related
    ENSGALP00010020392.1, ENSGALT00010034795.1

  4. XM_046903507.1 → XP_046759463.1  ribosomal protein S6 kinase 2 alpha isoform X10

  5. XM_046903504.1 → XP_046759460.1  ribosomal protein S6 kinase 2 alpha isoform X10

  6. XM_046903501.1 → XP_046759457.1  ribosomal protein S6 kinase 2 alpha isoform X1

    UniProtKB/TrEMBL
    A0A8V0YVU9

  7. XM_046903506.1 → XP_046759462.1  ribosomal protein S6 kinase 2 alpha isoform X10

  8. XM_040651630.2 → XP_040507564.1  ribosomal protein S6 kinase 2 alpha isoform X7

    UniProtKB/TrEMBL
    A0A8V0YP12
    Conserved Domains (2) summary
    cd05582
    Location:46 → 362
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14175
    Location:395 → 685
    STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)

  9. XM_040651629.2 → XP_040507563.1  ribosomal protein S6 kinase 2 alpha isoform X5

    UniProtKB/TrEMBL
    A0A8V0YP02, A0A8V0YP12
    Related
    ENSGALP00010020395.1, ENSGALT00010034801.1
    Conserved Domains (2) summary
    cd05582
    Location:64 → 380
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14175
    Location:413 → 703
    STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)

  10. XM_046903502.1 → XP_046759458.1  ribosomal protein S6 kinase 2 alpha isoform X1

    UniProtKB/TrEMBL
    A0A8V0YVU9

  11. XM_015297516.4 → XP_015153002.1  ribosomal protein S6 kinase 2 alpha isoform X6

    UniProtKB/TrEMBL
    A0A3Q2U5L9, A0A8V0YP12
    Related
    ENSGALP00010020389.1, ENSGALT00010034790.1
    Conserved Domains (4) summary
    smart00220
    Location:58 → 316
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:62 → 378
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14175
    Location:411 → 701
    STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)
    pfam00069
    Location:413 → 670
    Pkinase; Protein kinase domain

  12. XM_046903505.1 → XP_046759461.1  ribosomal protein S6 kinase 2 alpha isoform X10

  13. XM_015297513.4 → XP_015152999.1  ribosomal protein S6 kinase 2 alpha isoform X2

    UniProtKB/TrEMBL
    A0A3Q3AVG7, A0A8V0YVW3
    Related
    ENSGALP00010020383.1, ENSGALT00010034779.1
    Conserved Domains (4) summary
    smart00220
    Location:66 → 324
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:70 → 386
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14175
    Location:419 → 709
    STKc_RSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1)
    pfam00069
    Location:421 → 678
    Pkinase; Protein kinase domain

  14. XM_015297518.4 → XP_015153004.1  ribosomal protein S6 kinase 2 alpha isoform X9

    UniProtKB/TrEMBL
    A0A8V0YP12
    Conserved Domains (4) summary
    smart00220
    Location:80 → 338
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:84 → 400
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14091
    Location:434 → 666
    STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
    pfam00069
    Location:435 → 666
    Pkinase; Protein kinase domain

  15. XM_015297517.4 → XP_015153003.1  ribosomal protein S6 kinase 2 alpha isoform X8

    UniProtKB/TrEMBL
    A0A8V0YP12
    Conserved Domains (4) summary
    smart00220
    Location:80 → 338
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:84 → 400
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14091
    Location:434 → 666
    STKc_RSK_C; C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases
    pfam00069
    Location:435 → 666
    Pkinase; Protein kinase domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052595.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    258733..287255 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046931811.1 → XP_046787767.1  ribosomal protein S6 kinase 2 alpha isoform X3

    UniProtKB/TrEMBL
    A0A3Q3ADZ8

  2. XM_046931812.1 → XP_046787768.1  ribosomal protein S6 kinase 2 alpha isoform X4

    UniProtKB/TrEMBL
    A0A8V0YQT6

  3. XM_046931807.1 → XP_046787763.1  ribosomal protein S6 kinase 2 alpha isoform X1

    UniProtKB/TrEMBL
    A0A8V0YVU9

  4. XM_046931821.1 → XP_046787777.1  ribosomal protein S6 kinase 2 alpha isoform X10

  5. XM_046931818.1 → XP_046787774.1  ribosomal protein S6 kinase 2 alpha isoform X10

  6. XM_046931808.1 → XP_046787764.1  ribosomal protein S6 kinase 2 alpha isoform X1

    UniProtKB/TrEMBL
    A0A8V0YVU9

  7. XM_046931820.1 → XP_046787776.1  ribosomal protein S6 kinase 2 alpha isoform X10

  8. XM_046931815.1 → XP_046787771.1  ribosomal protein S6 kinase 2 alpha isoform X7

  9. XM_046931813.1 → XP_046787769.1  ribosomal protein S6 kinase 2 alpha isoform X5

    UniProtKB/TrEMBL
    A0A8V0YP02

  10. XM_046931809.1 → XP_046787765.1  ribosomal protein S6 kinase 2 alpha isoform X1

    UniProtKB/TrEMBL
    A0A8V0YVU9

  11. XM_046931814.1 → XP_046787770.1  ribosomal protein S6 kinase 2 alpha isoform X6

    UniProtKB/TrEMBL
    A0A3Q2U5L9

  12. XM_046931819.1 → XP_046787775.1  ribosomal protein S6 kinase 2 alpha isoform X10

  13. XM_046931810.1 → XP_046787766.1  ribosomal protein S6 kinase 2 alpha isoform X2

    UniProtKB/TrEMBL
    A0A3Q3AVG7

  14. XM_046931817.1 → XP_046787773.1  ribosomal protein S6 kinase 2 alpha isoform X9

  15. XM_046931816.1 → XP_046787772.1  ribosomal protein S6 kinase 2 alpha isoform X8

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18652.1 GenPept UniProtKB/Swiss-Prot:P18652

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