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GRB2 growth factor receptor bound protein 2 [ Gallus gallus (chicken) ]

Gene ID: 386572, updated on 3-Apr-2024

Summary

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Symbol
GRB2provided by CGNC
Full Name
growth factor receptor bound protein 2provided by CGNC
Primary source
CGNC:6067
See related
Ensembl:ENSGALG00010029705
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 18
Exon count:
9
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 18 NC_052549.1 (11374859..11421360, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 18 NC_052590.1 (10975328..11021849, complement)

Chromosome 18 - NC_052549.1Genomic Context describing neighboring genes Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 3 Neighboring gene uncharacterized LOC121107145 Neighboring gene mitochondrial ribosomal protein S7 Neighboring gene MIF4G domain containing Neighboring gene solute carrier family 25 member 19 Neighboring gene transmembrane protein 94 Neighboring gene CASK interacting protein 2 Neighboring gene melanin-concentrating hormone receptor 1 Neighboring gene tRNA splicing endonuclease subunit 54 Neighboring gene LLGL2, scribble cell polarity complex component

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphorylation of the SHC proteins on tyrosine correlates with the transformation of fibroblasts and erythroblasts by the v-sea tyrosine kinase. Crowe AJ, et al. Oncogene, 1994 Feb. PMID 8290264
  2. Sequence of a chicken cDNA encoding a GRB2 protein. Wasenius VM, et al. Gene, 1993 Dec 8. PMID 8262390
  3. The Dok-3/Grb2 adaptor module promotes inducible association of the lipid phosphatase SHIP with the BCR in a coreceptor-independent manner. Manno B, et al. Eur J Immunol, 2016 Nov. PMID 27550373
  4. Grb2 and the non-T cell activation linker NTAL constitute a Ca(2+)-regulating signal circuit in B lymphocytes. Stork B, et al. Immunity, 2004 Nov. PMID 15539154
  5. Subcellular localization of Grb2 by the adaptor protein Dok-3 restricts the intensity of Ca2+ signaling in B cells. Stork B, et al. EMBO J, 2007 Feb 21. PMID 17290227, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SHIP individually binds both components of the negative regulatory adaptor complex Dok-3 and Grb2;. Trimolecular complex formation between SHIP, Dok-3 and Grb2 is complemented by binding of SHIP to phosphorylated Igalpha/Igbeta for stable association in BCR signalosomes
    Title: The Dok-3/Grb2 adaptor module promotes inducible association of the lipid phosphatase SHIP with the BCR in a coreceptor-independent manner.
  2. The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters
    Title: The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
growth factor receptor-bound protein 2
Names
SH2/SH3 adapter GRB2
adapter protein GRB2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398121.1 → NP_001385050.1  growth factor receptor-bound protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000317
    UniProtKB/TrEMBL
    A3R0S3
    Conserved Domains (3) summary
    cd09941
    Location:56 → 150
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11946
    Location:1 → 56
    SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    cd11949
    Location:160 → 212
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

  2. NM_001398122.1 → NP_001385051.1  growth factor receptor-bound protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000317
    UniProtKB/TrEMBL
    A3R0S3
    Conserved Domains (3) summary
    cd09941
    Location:56 → 150
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11946
    Location:1 → 56
    SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    cd11949
    Location:160 → 212
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

  3. NM_001398123.1 → NP_001385052.1  growth factor receptor-bound protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000317
    UniProtKB/TrEMBL
    A3R0S3
    Related
    ENSGALP00010044538.1, ENSGALT00010071848.1
    Conserved Domains (3) summary
    cd09941
    Location:56 → 150
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11946
    Location:1 → 56
    SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    cd11949
    Location:160 → 212
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

  4. NM_001398124.1 → NP_001385053.1  growth factor receptor-bound protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000317
    UniProtKB/TrEMBL
    A0A8V1APV6
    Conserved Domains (3) summary
    cd09941
    Location:78 → 172
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11946
    Location:1 → 78
    SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    cd11949
    Location:182 → 234
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

  5. NM_204411.2 → NP_989742.2  growth factor receptor-bound protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000317
    UniProtKB/TrEMBL
    A3R0S3
    Conserved Domains (3) summary
    cd09941
    Location:56 → 150
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11946
    Location:1 → 56
    SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    cd11949
    Location:160 → 212
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052549.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    11374859..11421360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046901968.1 → XP_046757924.1  growth factor receptor-bound protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V1APV6

  2. XM_015295375.4 → XP_015150861.1  growth factor receptor-bound protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q07883
    UniProtKB/TrEMBL
    A0A8V1APV6
    Related
    ENSGALP00010044539.1, ENSGALT00010071849.1
    Conserved Domains (3) summary
    cd09941
    Location:78 → 172
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11946
    Location:1 → 78
    SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    cd11949
    Location:182 → 234
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

  3. XM_015295374.4 → XP_015150860.1  growth factor receptor-bound protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q07883
    UniProtKB/TrEMBL
    A0A8V1APV6
    Conserved Domains (3) summary
    cd09941
    Location:78 → 172
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11946
    Location:1 → 78
    SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    cd11949
    Location:182 → 234
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

  4. XM_025141539.3 → XP_024997307.1  growth factor receptor-bound protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q07883
    UniProtKB/TrEMBL
    A0A8V1APV6
    Conserved Domains (3) summary
    cd09941
    Location:78 → 172
    SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
    cd11946
    Location:1 → 78
    SH3_GRB2_N; N-terminal Src homology 3 domain of Growth factor receptor-bound protein 2
    cd11949
    Location:182 → 234
    SH3_GRB2_C; C-terminal Src homology 3 domain of Growth factor receptor-bound protein 2

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052590.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    10975328..11021849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046929249.1 → XP_046785205.1  growth factor receptor-bound protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V1APV6

  2. XM_046929248.1 → XP_046785204.1  growth factor receptor-bound protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V1APV6

  3. XM_046929247.1 → XP_046785203.1  growth factor receptor-bound protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V1APV6

  4. XM_046929250.1 → XP_046785206.1  growth factor receptor-bound protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V1APV6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07883.1 GenPept UniProtKB/Swiss-Prot:Q07883

Gene LinkOut

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