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KRT14 keratin 14 [ Homo sapiens (human) ]

Gene ID: 3861, updated on 4-Jan-2025

Summary

Official Symbol
KRT14provided by HGNC
Official Full Name
keratin 14provided by HGNC
Primary source
HGNC:HGNC:6416
See related
Ensembl:ENSG00000186847 MIM:148066; AllianceGenome:HGNC:6416
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K14; NFJ; CK14; EBS1; EBS3; EBS4; EBS1A; EBS1B; EBS1C; EBS1D
Summary
This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward skin (RPKM 3550.7) See more
Orthologs
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Genomic context

See KRT14 in Genome Data Viewer
Location:
17q21.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (41582279..41586895, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (42437869..42442485, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39738531..39743147, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39705412-39706025 Neighboring gene long intergenic non-protein coding RNA 974 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39708567-39709067 Neighboring gene keratin 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39731713-39732212 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:39735843-39736829 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39739983-39740483 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:39741549-39742050 Neighboring gene uncharacterized LOC124904003 Neighboring gene keratin 16

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in epidermis development PubMed 
involved_in epithelial cell differentiation  
involved_in hair cycle PubMed 
involved_in intermediate filament bundle assembly PubMed 
involved_in intermediate filament organization  
involved_in keratinocyte differentiation  
involved_in response to radiation  
involved_in stem cell differentiation  
Component Evidence Code Pubs
located_in basal part of cell  
located_in cornified envelope  
located_in cytoplasm PubMed 
is_active_in cytoskeleton  
located_in cytosol  
located_in extracellular exosome PubMed 
located_in intermediate filament PubMed 
is_active_in keratin filament  
located_in keratin filament PubMed 
located_in nucleus PubMed 
located_in nucleus PubMed 

General protein information

Preferred Names
keratin, type I cytoskeletal 14
Names
cytokeratin 14
keratin 14, type I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008624.2 RefSeqGene

    Range
    5000..9616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000526.5NP_000517.3  keratin, type I cytoskeletal 14

    Status: REVIEWED

    Source sequence(s)
    AC019349
    Consensus CDS
    CCDS11400.1
    UniProtKB/Swiss-Prot
    P02533, Q14715, Q53XY3, Q9BUE3, Q9UBN2, Q9UBN3, Q9UCY4
    Related
    ENSP00000167586.6, ENST00000167586.7
    Conserved Domains (1) summary
    pfam00038
    Location:114425
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    41582279..41586895 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    42437869..42442485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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