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TfIIEbeta Transcription factor IIEbeta [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38527, updated on 4-Apr-2024

Summary

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Official Symbol
TfIIEbetaprovided by FlyBase
Official Full Name
Transcription factor IIEbetaprovided by FlyBase
Primary source
FLYBASE:FBgn0015829
Locus tag
Dmel_CG1276
See related
AllianceGenome:FB:FBgn0015829
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1276; Dmel\CG1276; dTFIIE-S; dTFIIES; E[[S]]; TFIIbeta; TfIIE; TFIIE; TFIIEbeta
Summary
Involved in mRNA transcription by RNA polymerase II. Located in nucleus. Part of transcription factor TFIIE complex. Is expressed in organism. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 6. Orthologous to human GTF2E2 (general transcription factor IIE subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
64A12-64A12; 3-10 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4287038..4288349)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4287038..4288349)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene shrew Neighboring gene uncharacterized protein Neighboring gene Hexosaminidase 1 Neighboring gene uncharacterized protein Neighboring gene Ferredoxin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila TFIIE: purification, cloning, and functional reconstitution. Wang X, et al. Proc Natl Acad Sci U S A, 1997 Jan 21. PMID 9012800, Free PMC Article
  2. Transcription. Dichotomous regulators. Roberts SG, et al. Nature, 1995 May 11. PMID 7753162
  3. Trimeric complexes of Antp-TBP with TFIIEβ or Exd modulate transcriptional activity. Jiménez-Mejía G, et al. Hereditas, 2022 May 30. PMID 35637493, Free PMC Article
  4. Transcription factor TFIIEβ interacts with two exposed positions in helix 2 of the Antennapedia homeodomain to control homeotic function in Drosophila. Altamirano-Torres C, et al. PLoS One, 2018. PMID 30321227, Free PMC Article
  5. Control of transcription by Krüppel through interactions with TFIIB and TFIIE beta. Sauer F, et al. Nature, 1995 May 11. PMID 7753175

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Trimeric complexes of Antp-TBP with TFIIEbeta or Exd modulate transcriptional activity.
    Title: Trimeric complexes of Antp-TBP with TFIIEβ or Exd modulate transcriptional activity.
  2. interaction of Antp with TFIIEbeta is important for the functional specificity of Antennapedia, and amino acids 32 and 36 in Antp HD helix 2 are key for this interaction
    Title: Transcription factor TFIIEβ interacts with two exposed positions in helix 2 of the Antennapedia homeodomain to control homeotic function in Drosophila.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to TFIIH-class transcription factor complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription initiation at RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription initiation at RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIIE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIE complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIE complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of transcription factor TFIIE complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
transcription factor IIEbeta
Names
CG1276-PA
CG1276-PB
TFIIE small subunit
TfIIEbeta-PA
TfIIEbeta-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    4287038..4288349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169875.1 → NP_001163346.1  transcription factor IIEbeta, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163346.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JIC9
    Conserved Domains (1) summary
    cd07977
    Location:18 → 98
    TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity

  2. NM_079199.3 → NP_523923.1  transcription factor IIEbeta, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523923.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O96881
    Related
    FBpp0073090
    Conserved Domains (1) summary
    cd07977
    Location:61 → 141
    TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JIC9 E1JIC9
O96881 O96881

Gene LinkOut

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