RfC4 Replication factor C subunit 4 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: RfC4provided by FlyBase
Official Full Name: Replication factor C subunit 4provided by FlyBase
Primary source: FLYBASE:FBgn0260985
Locus tag: Dmel_CG14999
See related: AllianceGenome:FB:FBgn0260985
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 154910_at; BEST:GH24992; CG14999; Dmel\CG14999; DmRFC4; l(3)64Ai; l(3)A1; l(3)dsl-1; l(3)dsl1; l(3)e20; l(3)Rfc4; l(3)rfc40; l(3)SG13; l(3)SH17; rfc; RfC2; rfc4; Rfc4; rfc40; Rfc40; RfC40; RFC40; rfc[40]
Summary: Enables DNA binding activity. Involved in DNA damage checkpoint signaling; DNA replication; and DNA replication checkpoint signaling. Located in nucleus. Part of Elg1 RFC-like complex. Is expressed in several structures, including adult head; embryonic central brain neurons; embryonic/larval nervous system; extended germ band embryo; and larval neuroblast. Orthologous to human RFC2 (replication factor C subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (4134860..4136038, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (4134860..4136038, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to DNA clamp loader activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to DNA clamp loader activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA repair	TAS Traceable Author Statement more info	PubMed
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA replication	TAS Traceable Author Statement more info	PubMed
involved_in DNA replication checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA strand elongation involved in DNA replication	TAS Traceable Author Statement more info	PubMed
involved_in DNA-templated DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in leading strand elongation	ISS Inferred from Sequence or Structural Similarity more info
involved_in sister chromatid cohesion	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of DNA replication factor C complex	IBA Inferred from Biological aspect of Ancestor more info
part_of DNA replication factor C complex	ISS Inferred from Sequence or Structural Similarity more info
part_of Elg1 RFC-like complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

Names: CG14999-PA; Replication-factor-C 40kD subunit; RfC4-PA; lethal (3) SG13

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