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SCOT Succinyl-CoA:3-ketoacid CoA transferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38261, updated on 4-Apr-2024

Summary

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Official Symbol
SCOTprovided by FlyBase
Official Full Name
Succinyl-CoA:3-ketoacid CoA transferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0035298
Locus tag
Dmel_CG1140
See related
AllianceGenome:FB:FBgn0035298
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RH54340; cDNA B; CG1140; CT1116; Dmel\CG1140; DmSCOT
Summary
Enables 3-oxoacid CoA-transferase activity. Predicted to be involved in cellular ketone body metabolic process. Predicted to be active in mitochondrion. Is expressed in several structures, including embryonic Malpighian tubule; embryonic/larval fat body; endoderm anlage; extended germ band embryo; and inclusive hindgut primordium. Orthologous to several human genes including OXCT1 (3-oxoacid CoA-transferase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
62B11-62B12; 3-1.0 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1963143..1966805)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1963143..1966805)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Microfibril-associated protein 1 Neighboring gene mutator 2 Neighboring gene Centrobin Neighboring gene mauve Neighboring gene antisense RNA:CR45827 Neighboring gene antisense RNA:CR45828 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene arcus

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of succinyl-CoA:3-ketoacid CoA transferase from Drosophila melanogaster. Zhang M, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013 Oct. PMID 24100554, Free PMC Article
  2. Molecular cloning and tissue-specific expression of the mutator2 gene (mu2) in Drosophila melanogaster. Kasravi A, et al. Genetics, 1999 Jul. PMID 10388821, Free PMC Article
  3. Modes of metabolic compensation during mitochondrial disease using the Drosophila model of ATP6 dysfunction. Celotto AM, et al. PLoS One, 2011. PMID 21991365, Free PMC Article
  4. Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila. Teleman AA, et al. Cell Metab, 2008 Jan. PMID 18177722
  5. Fast and effective prediction of microRNA/target duplexes. Rehmsmeier M, et al. RNA, 2004 Oct. PMID 15383676, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The crystal structure of DmSCOT was determined at 2.64 A resolution.
    Title: Structure of succinyl-CoA:3-ketoacid CoA transferase from Drosophila melanogaster.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables CoA-transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables succinyl-CoA:3-oxo-acid CoA-transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables succinyl-CoA:3-oxo-acid CoA-transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables succinyl-CoA:3-oxo-acid CoA-transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular ketone body metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular ketone body metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ketone body catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Succinyl-CoA:3-ketoacid CoA transferase
Names
3-oxoacid CoA-transferase
3-oxoacid-CoA transferase
3-oxoacid-CoA-transferase
CG1140-PA
CG1140-PB
CG1140-PC
SCOT-PA
SCOT-PB
SCOT-PC
citric acid synthetase
NP_001261301.1
NP_647683.1
NP_728699.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1963143..1966805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167928.2 → NP_728699.1  Succinyl-CoA:3-ketoacid CoA transferase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728699.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8VV34
    Related
    FBpp0072722
    Conserved Domains (3) summary
    TIGR02428
    Location:284 → 490
    pcaJ_scoB_fam; 3-oxoacid CoA-transferase, B subunit
    COG1788
    Location:21 → 254
    AtoD; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid transport and metabolism]
    COG4670
    Location:25 → 497
    YdiF; Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid transport and metabolism]

  2. NM_001274372.1 → NP_001261301.1  Succinyl-CoA:3-ketoacid CoA transferase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261301.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C8VV34, M9PGX7
    Conserved Domains (2) summary
    TIGR02428
    Location:232 → 438
    pcaJ_scoB_fam; 3-oxoacid CoA-transferase, B subunit
    COG1788
    Location:2 → 202
    AtoD; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid transport and metabolism]

  3. NM_139426.3 → NP_647683.1  Succinyl-CoA:3-ketoacid CoA transferase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647683.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IRG3, Q9W058
    UniProtKB/TrEMBL
    C8VV34
    Related
    FBpp0072723
    Conserved Domains (2) summary
    TIGR02428
    Location:298 → 504
    pcaJ_scoB_fam; 3-oxoacid CoA-transferase, B subunit
    COG1788
    Location:35 → 268
    AtoD; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PGX7 M9PGX7
Q8IGC8 Q8IGC8
Q9W058.1 Q9W058

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