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Gk2 Glycerol kinase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38221, updated on 10-May-2024

Summary

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Official Symbol
Gk2provided by FlyBase
Official Full Name
Glycerol kinase 2provided by FlyBase
Primary source
FLYBASE:FBgn0035266
Locus tag
Dmel_CG7995
See related
AllianceGenome:FB:FBgn0035266
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7995; dGK; Dmel\CG7995; Gk; GK2
Summary
Enables glycerol kinase activity. Involved in glycerol-3-phosphate biosynthetic process and phosphorylation. Predicted to be active in mitochondrion. Is expressed in adult head and adult heart. Used to study glycerol kinase deficiency. Human ortholog(s) of this gene implicated in glycerol kinase deficiency. Orthologous to human GK (glycerol kinase) and GK2 (glycerol kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
62B1-62B1; 3-1.0 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1738407..1745421)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1738407..1745421)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene draper Neighboring gene Outer segment 4 Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class W b Neighboring gene uncharacterized protein Neighboring gene Chitinase 2 Neighboring gene uncharacterized protein Neighboring gene Dynein heavy chain at 62B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide maps of ribosomal occupancy provide insights into adaptive evolution and regulatory roles of uORFs during Drosophila development. Zhang H, et al. PLoS Biol, 2018 Jul. PMID 30028832, Free PMC Article
  2. Disruption of glycerol metabolism by RNAi targeting of genes encoding glycerol kinase results in a range of phenotype severity in Drosophila. Wightman PJ, et al. PLoS One, 2013. PMID 24039719, Free PMC Article
  3. Conserved family of glycerol kinase loci in Drosophila melanogaster. Martinez Agosto JA, et al. Mol Genet Metab, 2006 Aug. PMID 16545593, Free PMC Article
  4. Glycerol hypersensitivity in a Drosophila model for glycerol kinase deficiency is affected by mutations in eye pigmentation genes. Wightman PJ, et al. PLoS One, 2012. PMID 22427807, Free PMC Article
  5. Dicer partner proteins tune the length of mature miRNAs in flies and mammals. Fukunaga R, et al. Cell, 2012 Oct 26. PMID 23063653, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 1740909-1741094 mobile_element_type = transposon:pogo{}909

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerol kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycerol kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glycerol kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, alcohol group as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerol-3-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerol-3-phosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycerol-3-phosphate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in glycerol-3-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in triglyceride metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glycerol kinase 2
Names
CG7995-PA
CG7995-PB
CG7995-PC
CG7995-PD
CG7995-PE
CG7995-PF
Gk2-PA
Gk2-PB
Gk2-PC
Gk2-PD
Gk2-PE
Gk2-PF
glycerol kinase
NP_001286904.1
NP_647655.1
NP_728664.1
NP_728665.1
NP_728666.1
NP_728667.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1738407..1745421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299975.1 → NP_001286904.1  glycerol kinase 2, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286904.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961K9, Q9W094, Q9W095
    Conserved Domains (2) summary
    cd07792
    Location:31 → 533
    FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
    TIGR01311
    Location:31 → 533
    glycerol_kin; glycerol kinase

  2. NM_167913.3 → NP_728665.1  glycerol kinase 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728665.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961K9, Q9W094, Q9W095
    Related
    FBpp0072650
    Conserved Domains (2) summary
    cd07792
    Location:31 → 533
    FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
    TIGR01311
    Location:31 → 533
    glycerol_kin; glycerol kinase

  3. NM_167915.3 → NP_728667.1  glycerol kinase 2, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728667.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961K9, Q9W094, Q9W095
    Related
    FBpp0072651
    Conserved Domains (2) summary
    cd07792
    Location:31 → 533
    FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
    TIGR01311
    Location:31 → 533
    glycerol_kin; glycerol kinase

  4. NM_167914.2 → NP_728666.1  glycerol kinase 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728666.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961K9, Q9W094, Q9W095
    Related
    FBpp0072652
    Conserved Domains (2) summary
    cd07792
    Location:31 → 533
    FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
    TIGR01311
    Location:31 → 533
    glycerol_kin; glycerol kinase

  5. NM_167912.2 → NP_728664.1  glycerol kinase 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728664.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961K9, Q9W094, Q9W095
    Related
    FBpp0072653
    Conserved Domains (2) summary
    cd07792
    Location:31 → 533
    FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
    TIGR01311
    Location:31 → 533
    glycerol_kin; glycerol kinase

  6. NM_139398.3 → NP_647655.1  glycerol kinase 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647655.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961K9, Q9W094, Q9W095
    Related
    FBpp0072654
    Conserved Domains (2) summary
    cd07792
    Location:31 → 533
    FGGY_GK1-3_metazoa; Metazoan glycerol kinase 1 and 3-like proteins; belongs to the FGGY family of carbohydrate kinases
    TIGR01311
    Location:31 → 533
    glycerol_kin; glycerol kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q961K9 Q961K9
Q9W095 Q9W095

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