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Gipr gastric inhibitory polypeptide receptor [ Mus musculus (house mouse) ]

Gene ID: 381853, updated on 2-May-2024

Summary

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Official Symbol
Giprprovided by MGI
Official Full Name
gastric inhibitory polypeptide receptorprovided by MGI
Primary source
MGI:MGI:1352753
See related
Ensembl:ENSMUSG00000030406 AllianceGenome:MGI:1352753
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GIP-R; Gm160; Gm1081
Summary
Predicted to enable G protein-coupled peptide receptor activity; gastric inhibitory peptide receptor activity; and glucagon family peptide binding activity. Acts upstream of or within endocrine pancreas development. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in foregut-midgut junction; pancreas; and pancreas primordium. Human ortholog(s) of this gene implicated in cardiovascular system disease; diabetes mellitus; obesity; and type 2 diabetes mellitus. Orthologous to human GIPR (gastric inhibitory polypeptide receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 9.0), testis adult (RPKM 4.8) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 A3; 7 9.46 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (18889988..18904173, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19156063..19170248, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene glutaminyl-peptide cyclotransferase-like Neighboring gene STARR-positive B cell enhancer ABC_E1081 Neighboring gene small nuclear ribonucleoprotein D2 Neighboring gene echinoderm microtubule associated protein like 2 Neighboring gene microRNA 330 Neighboring gene VISTA enhancer mm1753 Neighboring gene G protein-coupled receptor 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Impacts of Glucose-Dependent Insulinotropic Polypeptide on Orthodontic Tooth Movement-Induced Bone Remodeling. Yamauchi T, et al. Int J Mol Sci, 2022 Aug 10. PMID 36012183, Free PMC Article
  2. Activation of GIPR Exerts Analgesic and Anxiolytic-Like Effects in the Anterior Cingulate Cortex of Mice. Wang XS, et al. Front Endocrinol (Lausanne), 2022. PMID 35712239, Free PMC Article
  3. GIPR gene expression in testis is mouse specific and can impact male mouse fertility. Killion EA, et al. Andrology, 2022 May. PMID 35224888
  4. Nutritional control of thyroid morphogenesis through gastrointestinal hormones. Takagishi M, et al. Curr Biol, 2022 Apr 11. PMID 35196509
  5. GIP receptor deletion in mice confers resistance to high-fat diet-induced obesity via alterations in energy expenditure and adipose tissue lipid metabolism. Boer GA, et al. Am J Physiol Endocrinol Metab, 2021 Apr 1. PMID 33645252

See all (116) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gastric inhibitory polypeptide receptor antagonism suppresses intramuscular adipose tissue accumulation and ameliorates sarcopenia.
    Title: Gastric inhibitory polypeptide receptor antagonism suppresses intramuscular adipose tissue accumulation and ameliorates sarcopenia.
  2. Genetic disruption of the Gipr in Apoe(-/-) mice promotes atherosclerosis.
    Title: Genetic disruption of the Gipr in Apoe(-/-) mice promotes atherosclerosis.
  3. Activation of GIPR Exerts Analgesic and Anxiolytic-Like Effects in the Anterior Cingulate Cortex of Mice.
    Title: Activation of GIPR Exerts Analgesic and Anxiolytic-Like Effects in the Anterior Cingulate Cortex of Mice.
  4. GIPR gene expression in testis is mouse specific and can impact male mouse fertility.
    Title: GIPR gene expression in testis is mouse specific and can impact male mouse fertility.
  5. GIPR Is Predominantly Localized to Nonadipocyte Cell Types Within White Adipose Tissue.
    Title: GIPR Is Predominantly Localized to Nonadipocyte Cell Types Within White Adipose Tissue.
  6. Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms.
    Title: Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms.
  7. GIPR Signaling in Immune Cells Maintains Metabolically Beneficial Type 2 Immune Responses in the White Fat From Obese Mice.
    Title: GIPR Signaling in Immune Cells Maintains Metabolically Beneficial Type 2 Immune Responses in the White Fat From Obese Mice.
  8. The gut hormone receptor GIPR links energy availability to the control of hematopoiesis.
    Title: The gut hormone receptor GIPR links energy availability to the control of hematopoiesis.
  9. GIP receptor deletion in mice confers resistance to high-fat diet-induced obesity via alterations in energy expenditure and adipose tissue lipid metabolism.
    Title: GIP receptor deletion in mice confers resistance to high-fat diet-induced obesity via alterations in energy expenditure and adipose tissue lipid metabolism.
  10. Sexually dimorphic metabolic responses to exposure of a high fat diet during pregnancy, lactation and early adulthood in Gipr(-/-) mice.
    Title: Sexually dimorphic metabolic responses to exposure of a high fat diet during pregnancy, lactation and early adulthood in Gipr(-/-) mice.
Submit: New GeneRIF Correction See all GeneRIFs (49)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables gastric inhibitory peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables gastric inhibitory peptide receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables gastric inhibitory peptide receptor activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables glucagon family peptide binding ISO
Inferred from Sequence Orthology
more info
  
enables peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide hormone binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in desensitization of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endocrine pancreas development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gastric inhibitory peptide signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuropeptide signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of insulin secretion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
gastric inhibitory polypeptide receptor
Names
glucose-dependent insulinotropic polypeptide receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080815.1 → NP_001074284.1  gastric inhibitory polypeptide receptor precursor

    See identical proteins and their annotated locations for NP_001074284.1

    Status: PROVISIONAL

    Source sequence(s)
    AC145199
    Consensus CDS
    CCDS39795.1
    UniProtKB/Swiss-Prot
    Q0P543, Q80UB4
    Related
    ENSMUSP00000092384.4, ENSMUST00000094790.5
    Conserved Domains (2) summary
    pfam00002
    Location:130 → 384
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:54 → 117
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    18889988..18904173 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540142.2 → XP_006540205.1  gastric inhibitory polypeptide receptor isoform X1

    See identical proteins and their annotated locations for XP_006540205.1

    Conserved Domains (2) summary
    cd15929
    Location:130 → 447
    7tmB1_GlucagonR-like; glucagon receptor-like subfamily, member of the class B family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:54 → 117
    HRM; Hormone receptor domain

  2. XM_006540143.2 → XP_006540206.1  gastric inhibitory polypeptide receptor isoform X1

    See identical proteins and their annotated locations for XP_006540206.1

    Conserved Domains (2) summary
    cd15929
    Location:130 → 447
    7tmB1_GlucagonR-like; glucagon receptor-like subfamily, member of the class B family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:54 → 117
    HRM; Hormone receptor domain

  3. XM_006540144.2 → XP_006540207.1  gastric inhibitory polypeptide receptor isoform X2

    See identical proteins and their annotated locations for XP_006540207.1

    Related
    ENSMUST00000206857.2
    Conserved Domains (2) summary
    cd15929
    Location:86 → 403
    7tmB1_GlucagonR-like; glucagon receptor-like subfamily, member of the class B family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:10 → 73
    HRM; Hormone receptor domain

  4. XM_006540145.2 → XP_006540208.1  gastric inhibitory polypeptide receptor isoform X2

    See identical proteins and their annotated locations for XP_006540208.1

    Conserved Domains (2) summary
    cd15929
    Location:86 → 403
    7tmB1_GlucagonR-like; glucagon receptor-like subfamily, member of the class B family of seven-transmembrane G protein-coupled receptors
    pfam02793
    Location:10 → 73
    HRM; Hormone receptor domain

RNA

  1. XR_004934121.1 RNA Sequence

  2. XR_004934120.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0P543.2 GenPept UniProtKB/Swiss-Prot:Q0P543

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