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Kmt2d lysine (K)-specific methyltransferase 2D [ Mus musculus (house mouse) ]

Gene ID: 381022, updated on 21-Apr-2024

Summary

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Official Symbol
Kmt2dprovided by MGI
Official Full Name
lysine (K)-specific methyltransferase 2Dprovided by MGI
Primary source
MGI:MGI:2682319
See related
Ensembl:ENSMUSG00000048154 AllianceGenome:MGI:2682319
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ALR; Mll2; Mll4; bapa; KMT2B; C430014K11Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in heterochromatin assembly; histone H3-K4 methylation; and oocyte growth. Acts upstream of or within in utero embryonic development and regulation of gene expression. Predicted to be located in nucleoplasm. Predicted to be part of MLL3/4 complex. Is expressed in several structures, including central nervous system; cranium; heart; integumental system; and sensory organ. Used to study Kabuki syndrome. Human ortholog(s) of this gene implicated in Kabuki syndrome and esophagus squamous cell carcinoma. Orthologous to human KMT2D (lysine methyltransferase 2D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 25.1), spleen adult (RPKM 21.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 F1; 15
Exon count:
57
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98729550..98771958, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98831669..98874077, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene dendrin Neighboring gene protein kinase, AMP-activated, gamma 1 non-catalytic subunit Neighboring gene STARR-positive B cell enhancer ABC_E1918 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:98663163-98663346 Neighboring gene STARR-seq mESC enhancer starr_39676 Neighboring gene STARR-positive B cell enhancer ABC_E10880 Neighboring gene Ras homolog enriched in brain like 1 Neighboring gene desert hedgehog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lysine methyltransferase Kmt2d regulates naive CD8(+) T cell activation-induced survival. Kim J, et al. Front Immunol, 2022. PMID 36741385, Free PMC Article
  2. Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation. Douillet D, et al. Nat Genet, 2020 Jun. PMID 32393859, Free PMC Article
  3. Expression pattern of Kmt2d in murine craniofacial tissues. Dong C, et al. Gene Expr Patterns, 2019 Dec. PMID 31228576, Free PMC Article
  4. Genetic and behavioral characterization of a Kmt2d mouse mutant, a new model for Kabuki Syndrome. Yamamoto PK, et al. Genes Brain Behav, 2019 Nov. PMID 30891914
  5. Promoter bivalency favors an open chromatin architecture in embryonic stem cells. Mas G, et al. Nat Genet, 2018 Oct. PMID 30224650

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment.
    Title: Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment.
  2. KMT2D Deficiency Causes Sensorineural Hearing Loss in Mice and Humans.
    Title: KMT2D Deficiency Causes Sensorineural Hearing Loss in Mice and Humans.
  3. Loss of Histone Methyltransferase KMT2D Attenuates Angiogenesis in the Ischemic Heart by Inhibiting the Transcriptional Activation of VEGF-A.
    Title: Loss of Histone Methyltransferase KMT2D Attenuates Angiogenesis in the Ischemic Heart by Inhibiting the Transcriptional Activation of VEGF-A.
  4. MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.
    Title: MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.
  5. Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.
    Title: Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.
  6. KMT2D Deficiency Promotes Myeloid Leukemias which Is Vulnerable to Ribosome Biogenesis Inhibition.
    Title: KMT2D Deficiency Promotes Myeloid Leukemias which Is Vulnerable to Ribosome Biogenesis Inhibition.
  7. KMT2D links TGF-beta signaling to noncanonical activin pathway and regulates pancreatic cancer cell plasticity.
    Title: KMT2D links TGF-β signaling to noncanonical activin pathway and regulates pancreatic cancer cell plasticity.
  8. Lysine methyltransferase Kmt2d regulates naive CD8[+] T cell activation-induced survival.
    Title: Lysine methyltransferase Kmt2d regulates naive CD8(+) T cell activation-induced survival.
  9. KMT2D deficiency disturbs the proliferation and cell cycle activity of dental epithelial cell line (LS8) partially via Wnt signaling.
    Title: KMT2D deficiency disturbs the proliferation and cell cycle activity of dental epithelial cell line (LS8) partially via Wnt signaling.
  10. Lysine methyltransferase 2D regulates muscle fiber size and muscle cell differentiation.
    Title: Lysine methyltransferase 2D regulates muscle fiber size and muscle cell differentiation.
Submit: New GeneRIF Correction See all GeneRIFs (56)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K4 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K4 methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histone H3K4 monomethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in oocyte growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of MLL3/4 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of MLL3/4 complex ISO
Inferred from Sequence Orthology
more info
  
part_of histone methyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
histone-lysine N-methyltransferase 2D
Names
ALL1-related protein
histone-lysine N-methyltransferase MLL2
lysine N-methyltransferase 2B
lysine N-methyltransferase 2D
myeloid/lymphoid or mixed-lineage leukemia 2
myeloid/lymphoid or mixed-lineage leukemia protein 2
NP_001028448.3
XP_017172163.1
XP_017172164.1
XP_017172165.1
XP_017172166.1
XP_017172167.1
XP_017172168.1
XP_017172169.1
XP_017172170.1
XP_017172171.1
XP_017172172.1
XP_017172173.1
XP_030104483.1
XP_030104484.1
XP_036015372.1
XP_036015373.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033276.3 → NP_001028448.3  histone-lysine N-methyltransferase 2D

    Status: VALIDATED

    Source sequence(s)
    AC161165
    Consensus CDS
    CCDS49725.2
    UniProtKB/Swiss-Prot
    Q6PDK2
    UniProtKB/TrEMBL
    A0A0A0MQ73
    Related
    ENSMUSP00000023741.9, ENSMUST00000023741.16
    Conserved Domains (11) summary
    smart00398
    Location:1978 → 2029
    HMG; high mobility group
    smart00542
    Location:5291 → 5378
    FYRC; FY-rich domain, C-terminal region
    smart00317
    Location:5448 → 5570
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd15509
    Location:228 → 273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:1385 → 1431
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:1334 → 1384
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:1462 → 1512
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134 → 217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:5083 → 5189
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:5233 → 5283
    FYRN; F/Y-rich N-terminus
    cl22851
    Location:275 → 320
    PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    98729550..98771958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316684.2 → XP_017172173.1  histone-lysine N-methyltransferase 2D isoform X15

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:1979 → 2030
    HMG; high mobility group
    smart00542
    Location:5292 → 5379
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:2068 → 2634
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228 → 273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:1386 → 1432
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:1335 → 1385
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:1463 → 1513
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134 → 217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:5084 → 5190
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:5233 → 5284
    FYRN; F/Y-rich N-terminus
    cd19209
    Location:5434 → 5588
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    cl22851
    Location:275 → 320
    PHD_SF; PHD finger superfamily

  2. XM_017316674.2 → XP_017172163.1  histone-lysine N-methyltransferase 2D isoform X1

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:1982 → 2033
    HMG; high mobility group
    smart00542
    Location:5295 → 5382
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:2071 → 2637
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228 → 273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:1386 → 1432
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:1335 → 1385
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:1463 → 1513
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134 → 217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:5087 → 5193
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:5236 → 5287
    FYRN; F/Y-rich N-terminus
    cd19209
    Location:5453 → 5607
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    cl22851
    Location:275 → 320
    PHD_SF; PHD finger superfamily

  3. XM_017316680.2 → XP_017172169.1  histone-lysine N-methyltransferase 2D isoform X9

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:1976 → 2027
    HMG; high mobility group
    smart00542
    Location:5289 → 5376
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:2065 → 2631
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228 → 273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:1385 → 1431
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:1334 → 1384
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:1462 → 1512
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134 → 217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:5081 → 5187
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:5230 → 5281
    FYRN; F/Y-rich N-terminus
    cd19209
    Location:5447 → 5601
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    cl22851
    Location:275 → 320
    PHD_SF; PHD finger superfamily

  4. XM_030248623.1 → XP_030104483.1  histone-lysine N-methyltransferase 2D isoform X7

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:1978 → 2029
    HMG; high mobility group
    smart00542
    Location:5291 → 5378
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:2067 → 2633
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228 → 273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:1385 → 1431
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:1334 → 1384
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:1462 → 1512
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134 → 217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:5083 → 5189
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:5232 → 5283
    FYRN; F/Y-rich N-terminus
    cd19209
    Location:5449 → 5603
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    cl22851
    Location:275 → 320
    PHD_SF; PHD finger superfamily

  5. XM_017316675.2 → XP_017172164.1  histone-lysine N-methyltransferase 2D isoform X2

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:1981 → 2032
    HMG; high mobility group
    smart00542
    Location:5294 → 5381
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:2070 → 2636
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228 → 273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:1385 → 1431
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:1334 → 1384
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:1462 → 1512
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134 → 217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:5086 → 5192
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:5235 → 5286
    FYRN; F/Y-rich N-terminus
    cd19209
    Location:5452 → 5606
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    cl22851
    Location:275 → 320
    PHD_SF; PHD finger superfamily

  6. XM_036159479.1 → XP_036015372.1  histone-lysine N-methyltransferase 2D isoform X12

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:1908 → 1959
    HMG; high mobility group
    smart00542
    Location:5221 → 5308
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:1997 → 2563
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228 → 273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:1386 → 1432
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:1335 → 1385
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:1463 → 1513
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134 → 217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:5013 → 5119
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd19209
    Location:5379 → 5533
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    pfam05964
    Location:5162 → 5213
    FYRN; F/Y-rich N-terminus
    cl22851
    Location:275 → 320
    PHD_SF; PHD finger superfamily

  7. XM_030248624.1 → XP_030104484.1  histone-lysine N-methyltransferase 2D isoform X8

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:1977 → 2028
    HMG; high mobility group
    smart00542
    Location:5290 → 5377
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:2066 → 2632
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228 → 273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:1386 → 1432
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:1335 → 1385
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:1463 → 1513
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134 → 217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:5082 → 5188
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:5231 → 5282
    FYRN; F/Y-rich N-terminus
    cd19209
    Location:5448 → 5602
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    cl22851
    Location:275 → 320
    PHD_SF; PHD finger superfamily

  8. XM_017316678.2 → XP_017172167.1  histone-lysine N-methyltransferase 2D isoform X5

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:1980 → 2031
    HMG; high mobility group
    smart00542
    Location:5293 → 5380
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:2069 → 2635
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228 → 273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:1386 → 1432
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:1335 → 1385
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:1463 → 1513
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134 → 217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:5085 → 5191
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:5234 → 5285
    FYRN; F/Y-rich N-terminus
    cd19209
    Location:5451 → 5605
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    cl22851
    Location:275 → 320
    PHD_SF; PHD finger superfamily

  9. XM_017316679.2 → XP_017172168.1  histone-lysine N-methyltransferase 2D isoform X6

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:1979 → 2030
    HMG; high mobility group
    smart00542
    Location:5292 → 5379
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:2068 → 2634
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228 → 273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:1386 → 1432
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:1335 → 1385
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:1463 → 1513
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134 → 217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:5084 → 5190
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:5233 → 5284
    FYRN; F/Y-rich N-terminus
    cd19209
    Location:5450 → 5604
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    cl22851
    Location:275 → 320
    PHD_SF; PHD finger superfamily

  10. XM_017316681.2 → XP_017172170.1  histone-lysine N-methyltransferase 2D isoform X10

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:1975 → 2026
    HMG; high mobility group
    smart00542
    Location:5288 → 5375
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:2064 → 2630
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228 → 273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:1386 → 1432
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:1335 → 1385
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:1463 → 1513
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134 → 217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:5080 → 5186
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:5229 → 5280
    FYRN; F/Y-rich N-terminus
    cd19209
    Location:5446 → 5600
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    cl22851
    Location:275 → 320
    PHD_SF; PHD finger superfamily

  11. XM_017316677.2 → XP_017172166.1  histone-lysine N-methyltransferase 2D isoform X4

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:1982 → 2033
    HMG; high mobility group
    smart00542
    Location:5294 → 5381
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:2070 → 2636
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228 → 273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:1386 → 1432
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:1335 → 1385
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:1463 → 1513
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134 → 217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:5086 → 5192
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:5235 → 5286
    FYRN; F/Y-rich N-terminus
    cd19209
    Location:5452 → 5606
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    cl22851
    Location:275 → 320
    PHD_SF; PHD finger superfamily

  12. XM_017316682.2 → XP_017172171.1  histone-lysine N-methyltransferase 2D isoform X11

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:1982 → 2033
    HMG; high mobility group
    smart00542
    Location:5295 → 5382
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:2071 → 2637
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228 → 273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:1386 → 1432
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:1335 → 1385
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:1463 → 1513
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134 → 217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:5087 → 5193
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:5236 → 5287
    FYRN; F/Y-rich N-terminus
    cd19209
    Location:5437 → 5591
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    cl22851
    Location:275 → 320
    PHD_SF; PHD finger superfamily

  13. XM_017316676.2 → XP_017172165.1  histone-lysine N-methyltransferase 2D isoform X3

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (12) summary
    smart00398
    Location:1981 → 2032
    HMG; high mobility group
    smart00542
    Location:5294 → 5381
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:2070 → 2636
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:227 → 272
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:1385 → 1431
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:1334 → 1384
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:1462 → 1512
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:133 → 216
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd15698
    Location:5086 → 5192
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    pfam05964
    Location:5235 → 5286
    FYRN; F/Y-rich N-terminus
    cd19209
    Location:5452 → 5606
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    cl22851
    Location:274 → 319
    PHD_SF; PHD finger superfamily

  14. XM_036159480.1 → XP_036015373.1  histone-lysine N-methyltransferase 2D isoform X14

    Conserved Domains (6) summary
    smart00398
    Location:356 → 407
    HMG; high mobility group
    smart00542
    Location:3669 → 3756
    FYRC; FY-rich domain, C-terminal region
    PHA03247
    Location:445 → 1011
    PHA03247; large tegument protein UL36; Provisional
    cd15698
    Location:3461 → 3567
    ePHD2_KMT2D; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cd19209
    Location:3827 → 3981
    SET_KMT2D; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins
    pfam05964
    Location:3610 → 3661
    FYRN; F/Y-rich N-terminus

  15. XM_017316683.3 → XP_017172172.1  histone-lysine N-methyltransferase 2D isoform X13

    UniProtKB/Swiss-Prot
    Q6PDK2
    Conserved Domains (8) summary
    smart00398
    Location:1982 → 2033
    HMG; high mobility group
    PHA03247
    Location:2071 → 2637
    PHA03247; large tegument protein UL36; Provisional
    cd15509
    Location:228 → 273
    PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
    cd15513
    Location:1386 → 1432
    PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
    cd15597
    Location:1335 → 1385
    PHD3_KMT2D; PHD finger 3 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15601
    Location:1463 → 1513
    PHD5_KMT2D; PHD finger 5 found in Histone-lysine N-methyltransferase 2D (KMT2D)
    cd15695
    Location:134 → 217
    ePHD1_KMT2D; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2D (KMT2D)
    cl22851
    Location:275 → 320
    PHD_SF; PHD finger superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033388.1: Suppressed sequence

    Description
    NM_001033388.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PDK2.2 GenPept UniProtKB/Swiss-Prot:Q6PDK2

Gene LinkOut

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