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Prp4k Pre-mRNA processing factor 4 kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38032, updated on 10-May-2024

Summary

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Official Symbol
Prp4kprovided by FlyBase
Official Full Name
Pre-mRNA processing factor 4 kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0027587
Locus tag
Dmel_CG7028
See related
AllianceGenome:FB:FBgn0027587
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH04978; CG7028; Dmel\CG7028; prp4; PRP4; PRP4K
Summary
Enables protein serine/threonine kinase activity. Involved in positive regulation of hippo signaling. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism. Orthologous to human PRPF4B (pre-mRNA processing factor 4B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
61B2-61B2; 3-1 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (207184..211457, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (207184..211457, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene mrityu Neighboring gene Glycerol kinase 1 Neighboring gene Nitrilase and fragile histidine triad fusion protein Neighboring gene uncharacterized protein Neighboring gene thoc7 Neighboring gene Dis3 like 3'-5' exoribonuclease 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Spliceosome factors target timeless (tim) mRNA to control clock protein accumulation and circadian behavior in Drosophila. Shakhmantsir I, et al. Elife, 2018 Dec 5. PMID 30516472, Free PMC Article
  2. Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K. Cho YS, et al. Nat Commun, 2018 Apr 25. PMID 29695716, Free PMC Article
  3. Hippo-Independent Regulation of Yki/Yap/Taz: A Non-canonical View. Cho YS, et al. Front Cell Dev Biol, 2021. PMID 33869224, Free PMC Article
  4. Cell cycle control of wnt receptor activation. Davidson G, et al. Dev Cell, 2009 Dec. PMID 20059949
  5. The computational analysis of scientific literature to define and recognize gene expression clusters. Raychaudhuri S, et al. Nucleic Acids Res, 2003 Aug 1. PMID 12888516, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA cis splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of hippo signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome HDA PubMed 
part_of precatalytic spliceosome HDA PubMed 

General protein information

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Preferred Names
Pre-mRNA processing factor 4 kinase
Names
CG7028-PA
CG7028-PB
CG7028-PC
CG7028-PD
CG7028-PE
Prp4k-PA
Prp4k-PB
Prp4k-PC
Prp4k-PD
Prp4k-PE
pre-mRNA processing 4
NP_001261186.1
NP_001286884.1
NP_001286885.1
NP_001286886.1
NP_612010.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    207184..211457 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299957.1 → NP_001286886.1  Pre-mRNA processing factor 4 kinase, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286886.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9Y145
    Conserved Domains (2) summary
    smart00220
    Location:594 → 903
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14135
    Location:586 → 903
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4

  2. NM_001299956.1 → NP_001286885.1  Pre-mRNA processing factor 4 kinase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286885.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JG22
    Conserved Domains (2) summary
    smart00220
    Location:593 → 902
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14135
    Location:585 → 902
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4

  3. NM_001274257.1 → NP_001261186.1  Pre-mRNA processing factor 4 kinase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261186.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PGI7
    Conserved Domains (2) summary
    smart00220
    Location:598 → 907
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14135
    Location:590 → 907
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4

  4. NM_138166.4 → NP_612010.1  Pre-mRNA processing factor 4 kinase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_612010.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9Y145
    Related
    FBpp0072427
    Conserved Domains (2) summary
    smart00220
    Location:594 → 903
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14135
    Location:586 → 903
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4

  5. NM_001299955.1 → NP_001286884.1  Pre-mRNA processing factor 4 kinase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286884.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JAG8
    Conserved Domains (2) summary
    smart00220
    Location:599 → 908
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14135
    Location:591 → 908
    STKc_PRP4; Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PGI7 M9PGI7
Q9Y145 Q9Y145
X2JAG8 X2JAG8
X2JG22 X2JG22

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