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PB1-F2 PB1-F2 protein [ Influenza A virus (A/Puerto Rico/8/1934(H1N1)) ]

Gene ID: 3802042, updated on 18-Aug-2023

Summary

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Gene symbol
PB1-F2
Gene description
PB1-F2 protein
Locus tag
FLUAVs2gp2
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Influenza A virus (A/Puerto Rico/8/1934(H1N1)) (strain: A/Puerto Rico/8/1934, serogroup: H1N1)
Lineage
Viruses; ssRNA viruses; ssRNA negative-strand viruses; Orthomyxoviridae; Influenzavirus A
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Genomic context

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Location:
segment: 2
Sequence:
NC_002021.1 (119..382)

NC_002021.1Genomic Context describing neighboring genes Neighboring gene polymerase PB1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002021.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Composition-dependent membrane disruption by the proapoptotic protein PB1F2 from HK97 influenza A virus. Wang Y, et al. FEBS Lett, 2018 Aug. PMID 29933499
  2. Synchrotron Infrared and Deep UV Fluorescent Microspectroscopy Study of PB1-F2 β-Aggregated Structures in Influenza A Virus-infected Cells. Chevalier C, et al. J Biol Chem, 2016 Apr 22. PMID 26896002, Free PMC Article
  3. The influenza virus protein PB1-F2 interacts with IKKβ and modulates NF-κB signalling. Reis AL, et al. PLoS One, 2013. PMID 23704945, Free PMC Article
  4. Naturally occurring swine influenza A virus PB1-F2 phenotypes that contribute to superinfection with Gram-positive respiratory pathogens. Weeks-Gorospe JN, et al. J Virol, 2012 Sep. PMID 22674997, Free PMC Article
  5. Restored PB1-F2 in the 2009 pandemic H1N1 influenza virus has minimal effects in swine. Pena L, et al. J Virol, 2012 May. PMID 22379102, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Influenza PB1-F2 Inhibits Avian MAVS Signaling.
    Title: Influenza PB1-F2 Inhibits Avian MAVS Signaling.
  2. The primary membrane target of PB1F2 is phosphatidylcholine, the lipid that forms the major component of mitochondrial inner membranes. PB1F2 disrupts the integrity of lipid membranes by forming micelle-like PB1F2-lipid assemblies.
    Title: Composition-dependent membrane disruption by the proapoptotic protein PB1F2 from HK97 influenza A virus.
  3. results constitute an important step forward in the understanding of the cell type-dependent function of PB1-F2.
    Title: Synchrotron Infrared and Deep UV Fluorescent Microspectroscopy Study of PB1-F2 β-Aggregated Structures in Influenza A Virus-infected Cells.
  4. Influenza A virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity.
    Title: Influenza A virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity.
  5. Mutations in PB1-F2 gene is associated with virulence.
    Title: Mass spectrometry-based comparative sequence analysis for the genetic monitoring of influenza A(H1N1)pdm09 virus.
  6. NLRX1 enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein, as well as preventing mitochondrial-induced apoptosis
    Title: NLRX1 prevents mitochondrial induced apoptosis and enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein.
  7. PB1-F2 inhibits the activation of NF-kappaB dependent signalling pathways.
    Title: The influenza virus protein PB1-F2 interacts with IKKβ and modulates NF-κB signalling.
  8. MIF and GNbeta2 interacted with influenza A H1N1 virus PB1-F2 protein.
    Title: Identification of cellular proteins interacting with influenza A virus PB1-F2 protein.
  9. PB1-F2 protein of influenza A virus interacts with human MOAP-1 protein.
    Title: [PB1-F2 protein of influenza A virus interacts with human MOAP-1 protein].
  10. PB1-F2 contribute to superinfection with Gram-positive respiratory pathogens.
    Title: Naturally occurring swine influenza A virus PB1-F2 phenotypes that contribute to superinfection with Gram-positive respiratory pathogens.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
PB1-F2 protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002021.1 Reference assembly

    Range
    119..382
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_418248.1 PB1-F2 protein [Influenza A virus (A/Puerto Rico/8/1934(H1N1))]

    See identical proteins and their annotated locations for YP_418248.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    A4GXH2, P0C0U1, Q20N29
    UniProtKB/TrEMBL
    A0A2R4QPM4, D3J176, F0TTB0, F0TTC1, F0TTD2, F0TTE3, F0TTF4, F0TTH6, F5CGM0, F5CGN2, F5CGP2, M9V623, T2AA66
    Conserved Domains (1) summary
    pfam11986
    Location:1 → 87
    PB1-F2; Influenza A Proapoptotic protein
Protein Accession Links
GenPept Link UniProtKB Link
P0C0U1.1

Gene LinkOut

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