Orc4 Origin recognition complex subunit 4 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Orc4provided by FlyBase
Official Full Name: Origin recognition complex subunit 4provided by FlyBase
Primary source: FLYBASE:FBgn0023181
Locus tag: Dmel_CG2917
See related: AllianceGenome:FB:FBgn0023181
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG2917; Dmel\CG2917; dmOrc4; DmORC4; ORC; orc4; ORC4; rDmORC
Summary: Predicted to enable DNA replication origin binding activity. Involved in DNA replication initiation. Part of nuclear origin of replication recognition complex. Is expressed in several structures, including embryonic brain; embryonic/larval nervous system; and extended germ band embryo. Used to study Meier-Gorlin syndrome 2. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 2. Orthologous to human ORC4 (origin recognition complex subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (24795740..24797414, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (20683263..20684937, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA replication origin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribonucleoprotein complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication initiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of nuclear origin of replication recognition complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear origin of replication recognition complex	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of origin recognition complex	IEA Inferred from Electronic Annotation more info

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