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ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) [ Gallus gallus (chicken) ]

Gene ID: 378932, updated on 5-Mar-2024

Summary

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Symbol
ITGA5provided by CGNC
Full Name
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)provided by CGNC
Primary source
CGNC:49148
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 34
Exon count:
26
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 34 NC_052565.1 (726940..740914)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 34 NC_052606.1 (675777..683594)

Chromosome 34 - NC_052565.1Genomic Context describing neighboring genes Neighboring gene NCK associated protein 1 like Neighboring gene gametocyte specific factor 2 Neighboring gene zinc finger protein 385A Neighboring gene coatomer protein complex subunit zeta 1 Neighboring gene microRNA mir-148b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sensory neuron subtypes have unique substratum preference and receptor expression before target innervation. Guan W, et al. J Neurosci, 2003 Mar 1. PMID 12629182, Free PMC Article
  2. Enhancement of ovarian tumor detection with αvβ3 integrin-targeted ultrasound molecular imaging agent in laying hens: a preclinical model of spontaneous ovarian cancer. Barua A, et al. Int J Gynecol Cancer, 2014 Jan. PMID 24304684
  3. Cranial neural crest recycle surface integrins in a substratum-dependent manner to promote rapid motility. Strachan LR, et al. J Cell Biol, 2004 Nov 8. PMID 15520227, Free PMC Article
  4. Communication between integrin receptors facilitates epicardial cell adhesion and matrix organization. Pae SH, et al. Dev Dyn, 2008 Apr. PMID 18351655

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that cooperation between alpha(4)beta(1)/alpha(5)beta(1) and RGD integrins is important for epicardial mesothelial cell adhesion and subepicardial matrix formation.
    Title: Communication between integrin receptors facilitates epicardial cell adhesion and matrix organization.
  2. alphavbeta3 integrin-targeted imaging agent enhances the visualization of ovarian tumor-associated angiogenic microvessels in hens with early-stage ovarian cancer.
    Title: Enhancement of ovarian tumor detection with αvβ3 integrin-targeted ultrasound molecular imaging agent in laying hens: a preclinical model of spontaneous ovarian cancer.
  3. On laminin, neural crest cells accumulated internalized integrin alpha 6 laminin receptors but not integrin alpha 5 fibronectin receptors; rapid cranial NCC motility on laminin requires integrin recycling
    Title: Cranial neural crest recycle surface integrins in a substratum-dependent manner to promote rapid motility.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables integrin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of integrin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
LOW QUALITY PROTEIN: integrin alpha-5; integrin alpha-5
Names
integrin alpha 5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052565.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    726940..740914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046904986.1 → XP_046760942.1  LOW QUALITY PROTEIN: integrin alpha-5 isoform X1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052606.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    675777..683594
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040693851.2 → XP_040549785.1  integrin alpha-5 isoform X2

    Conserved Domains (1) summary
    smart00191
    Location:49 → 106
    Int_alpha; Integrin alpha (beta-propellor repeats)
Nucleotide Protein Strain
Heading Accession and Version

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