BUB1B BUB1 mitotic checkpoint serine/threonine kinase B [Gallus gallus (chicken)] - Gene

Summary

Symbol: BUB1Bprovided by CGNC
Full Name: BUB1 mitotic checkpoint serine/threonine kinase Bprovided by CGNC
Primary source: CGNC:3590
See related: Ensembl:ENSGALG00010023017
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: BUBR1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	5	NC_052536.1 (782890..807156)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	5	NC_052577.1 (777477..801740)

Chromosome 5 - NC_052536.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CENP-A-depleted cells exhibit a specific defect in maintaining kinetochore localization of the checkpoint protein BubR1 under conditions of checkpoint activation
Title: CENP-A is required for accurate chromosome segregation and sustained kinetochore association of BubR1.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in meiotic sister chromatid cohesion, centromeric	IEA Inferred from Electronic Annotation more info	PubMed
involved_in mitotic spindle assembly checkpoint signaling	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Names: BUB1 budding uninhibited by benzimidazoles 1 homolog beta; budding uninhibited by benzimidazoles 1 homolog beta

NP_989734.3

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204403.3 → NP_989734.3 mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Status: VALIDATED

Source sequence(s)

JAENSK010000212

UniProtKB/TrEMBL

Q800D4

Related

ENSGALP00010033924.1, ENSGALT00010056073.1

Conserved Domains (2) summary

smart00777
Location:44 → 166

Mad3_BUB1_I; Mad3/BUB1 hoMad3/BUB1 homology region 1

cd14029
Location:781 → 1084

STKc_BubR1_vert; Catalytic domain of the Serine/Threonine kinase, Vertebrate Spindle assembly checkpoint protein BubR1