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RIPK1 receptor interacting serine/threonine kinase 1 [ Gallus gallus (chicken) ]

Gene ID: 378921, updated on 3-Apr-2024

Summary

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Official Symbol
RIPK1provided by CGNC
Official Full Name
receptor interacting serine/threonine kinase 1provided by CGNC
Primary source
CGNC:9719
See related
Ensembl:ENSGALG00010011418
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
RIP-1
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
13
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (66061492..66082425, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (66010464..66031398, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene tubulin beta 2B class IIb Neighboring gene biphenyl hydrolase like Neighboring gene tubulin, beta 2A class IIa Neighboring gene uncharacterized LOC121109966 Neighboring gene uncharacterized LOC124417770 Neighboring gene NAD(P)H quinone dehydrogenase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression analysis of cytosolic DNA-sensing pathway genes in the intestinal mucosal layer of necrotic enteritis-induced chicken. Rengaraj D, et al. Vet Immunol Immunopathol, 2016 Feb. PMID 26872625
  2. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Outer membrane vesicles of avian pathogenic Escherichia coli induce necroptosis and NF-kappaB activation in chicken macrophages via RIPK1 mediation.
    Title: Outer membrane vesicles of avian pathogenic Escherichia coli induce necroptosis and NF-κB activation in chicken macrophages via RIPK1 mediation.
  2. RNA sequencing results revealed that the chicken RIPK1 was more upregulated in the intestinal mucosal layer of Necrotic enteritis induced chicken lines that are resistant and sensitive to avian leukosis and Marek's disease.
    Title: Expression analysis of cytosolic DNA-sensing pathway genes in the intestinal mucosal layer of necrotic enteritis-induced chicken.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables JUN kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
receptor-interacting serine/threonine-protein kinase 1
Names
receptor (TNFRSF)-interacting serine-threonine kinase 1
NP_001384153.1
NP_001384154.1
NP_989733.3
XP_046766185.1
XP_046766186.1
XP_046773405.1
XP_046773408.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001397224.1 → NP_001384153.1  receptor-interacting serine/threonine-protein kinase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000040
    UniProtKB/TrEMBL
    A0A8V0YAV2, Q5F3U2
    Related
    ENSGALP00010015565.1, ENSGALT00010027311.1
    Conserved Domains (2) summary
    cd08777
    Location:595 → 680
    Death_RIP1; Death Domain of Receptor-Interacting Protein 1
    cd14027
    Location:19 → 285
    STKc_RIP1; Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 1

  2. NM_001397225.1 → NP_001384154.1  receptor-interacting serine/threonine-protein kinase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000040
    UniProtKB/TrEMBL
    A0A8V0YAV2, Q5F3U2
    Conserved Domains (2) summary
    cd08777
    Location:595 → 680
    Death_RIP1; Death Domain of Receptor-Interacting Protein 1
    cd14027
    Location:19 → 285
    STKc_RIP1; Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 1

  3. NM_204402.3 → NP_989733.3  receptor-interacting serine/threonine-protein kinase 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000040
    UniProtKB/TrEMBL
    A0A8V0YAV2
    Related
    ENSGALP00010015569.1, ENSGALT00010027315.1
    Conserved Domains (2) summary
    cd08777
    Location:571 → 656
    Death_RIP1; Death Domain of Receptor-Interacting Protein 1
    cd14027
    Location:19 → 285
    STKc_RIP1; Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    66061492..66082425 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046917449.1 → XP_046773405.1  receptor-interacting serine/threonine-protein kinase 1 isoform X1

  2. XM_046917452.1 → XP_046773408.1  receptor-interacting serine/threonine-protein kinase 1 isoform X2

    UniProtKB/TrEMBL
    Q5F3U2

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    66010464..66031398 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046910229.1 → XP_046766185.1  receptor-interacting serine/threonine-protein kinase 1 isoform X1

  2. XM_046910230.1 → XP_046766186.1  receptor-interacting serine/threonine-protein kinase 1 isoform X2

    UniProtKB/TrEMBL
    Q5F3U2
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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