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mtr 5-methyltetrahydrofolate-homocysteine methyltransferase [ Danio rerio (zebrafish) ]

Gene ID: 378847, updated on 4-Jan-2025

Summary

Official Symbol
mtrprovided by ZNC
Official Full Name
5-methyltetrahydrofolate-homocysteine methyltransferaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-031001-5
See related
Ensembl:ENSDARG00000104906 AllianceGenome:ZFIN:ZDB-GENE-031001-5
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb830
Summary
Predicted to enable methionine synthase activity. Predicted to be involved in homocysteine metabolic process; methionine biosynthetic process; and tetrahydrofolate metabolic process. Predicted to act upstream of or within amino acid biosynthetic process; methylation; and pteridine-containing compound metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including anterior neural tube; central nervous system; digestive system; immature eye; and mesoderm. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); autistic disorder; hematologic cancer (multiple); and hyperhomocysteinemia. Orthologous to human MTR (5-methyltetrahydrofolate-homocysteine methyltransferase). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information
Annotation category: partial on reference assembly
Orthologs
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Genomic context

See mtr in Genome Data Viewer
Location:
chromosome: 12
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (47081695..47116074)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (47134939..47164436)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene ornithine aminotransferase Neighboring gene zinc finger, RAN-binding domain containing 1a Neighboring gene ryanodine receptor 2a (cardiac) Neighboring gene cholinergic receptor, muscarinic 3b

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cobalamin binding  
enables metal ion binding  
enables methionine synthase activity  
enables methionine synthase activity  
enables methyltransferase activity  
enables transferase activity  
enables zinc ion binding  
Component Evidence Code Pubs
located_in cytoplasm  
is_active_in cytosol  

General protein information

Preferred Names
methionine synthase
NP_932338.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198072.1NP_932338.1  methionine synthase

    See identical proteins and their annotated locations for NP_932338.1

    Status: PROVISIONAL

    Source sequence(s)
    AF506733
    UniProtKB/TrEMBL
    Q8JIY6
    Related
    ENSDARP00000139035.2, ENSDART00000158568.2
    Conserved Domains (5) summary
    COG0646
    Location:19337
    MetH1; Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]
    PRK09490
    Location:131259
    metH; B12-dependent methionine synthase; Provisional
    cd00740
    Location:369625
    MeTr; MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent ...
    cd02069
    Location:669895
    methionine_synthase_B12_BD; B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy).
    pfam02965
    Location:9631243
    Met_synt_B12; Vitamin B12 dependent methionine synthase, activation domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    47081695..47116074
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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