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sh3gl1b SH3-domain GRB2-like 1b [ Danio rerio (zebrafish) ]

Gene ID: 378838, updated on 11-Apr-2024

Summary

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Official Symbol
sh3gl1bprovided by ZNC
Official Full Name
SH3-domain GRB2-like 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-031001-6
See related
Ensembl:ENSDARG00000002642 AllianceGenome:ZFIN:ZDB-GENE-031001-6
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb831; sh3gl1
Summary
Predicted to enable lipid binding activity. Predicted to be involved in synaptic vesicle uncoating. Predicted to be located in early endosome membrane. Predicted to be active in cytoplasm; glutamatergic synapse; and presynapse. Is expressed in several structures, including cardiovascular system; mesoderm; musculature system; nervous system; and neural tube. Human ortholog(s) of this gene implicated in acute myeloid leukemia and high grade glioma. Orthologous to human SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 8
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (18840704..18879900, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (18810608..18849483, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110440007 Neighboring gene MPN domain containing Neighboring gene RAR-related orphan receptor C a Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Bb

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Essential role of SH3-domain GRB2-like 3 for vascular lumen maintenance in zebrafish. Zhao Y, et al. Arterioscler Thromb Vasc Biol, 2013 Jun. PMID 23539215
  2. eena Promotes myeloid proliferation through stimulating ERK1/2 phosphorylation in zebrafish. Le HY, et al. J Biol Chem, 2008 Jun 20. PMID 18413315
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in synaptic vesicle uncoating IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in podosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SH3-domain GRB2-like 1b; endophilin-A2
Names
SH3-domain GRB2-like 1
eena

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201497.1 → NP_958905.1  SH3-domain GRB2-like 1b

    See identical proteins and their annotated locations for NP_958905.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045942
    UniProtKB/TrEMBL
    B2GP10, Q7ZVA3
    Related
    ENSDARP00000091264.4, ENSDART00000100491.6
    Conserved Domains (2) summary
    cd07592
    Location:25 → 247
    BAR_Endophilin_A; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A
    cd11803
    Location:293 → 346
    SH3_Endophilin_A; Src homology 3 domain of Endophilin-A

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    18840704..18879900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478204.1 → XP_021333879.1  endophilin-A2 isoform X1

    UniProtKB/TrEMBL
    A0A0R4IGE6, A0A8M9Q9K3
    Related
    ENSDARP00000133533.1, ENSDART00000169043.2
    Conserved Domains (2) summary
    cd07592
    Location:25 → 247
    BAR_Endophilin_A; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A
    cd11803
    Location:309 → 362
    SH3_Endophilin_A; Src homology 3 domain of Endophilin-A

  2. XM_005166793.4 → XP_005166850.1  endophilin-A2 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BE91
    Conserved Domains (2) summary
    cd07592
    Location:25 → 247
    BAR_Endophilin_A; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A
    cd11803
    Location:292 → 345
    SH3_Endophilin_A; Src homology 3 domain of Endophilin-A

  3. XM_009303889.3 → XP_009302164.1  endophilin-A2 isoform X2

    UniProtKB/TrEMBL
    A0A8M3BBQ5
    Conserved Domains (2) summary
    cd07592
    Location:25 → 247
    BAR_Endophilin_A; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A
    cd11803
    Location:308 → 361
    SH3_Endophilin_A; Src homology 3 domain of Endophilin-A

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394718.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    197..37703 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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