KIT KIT proto-oncogene, receptor tyrosine kinase [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: KITprovided by CGNC
Official Full Name: KIT proto-oncogene, receptor tyrosine kinaseprovided by CGNC
Primary source: CGNC:10414
See related: Ensembl:ENSGALG00010013314
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: SCFR
Annotation information: Annotation category: suggests misassembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	4	NC_052535.1 (64787795..64839844, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	4	NC_052576.1 (64770973..64822939, complement)

Chromosome 4 - NC_052535.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study reveals the distribution of interstitial cells of Cajal, quantifies the expression of c-Kit mRNA in the intestine of adult chicken, and also compares the c-Kit-positive cell types morphologically
Title: The identification of c-Kit-positive cells in the intestine of chicken.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables cytokine binding	IEA Inferred from Electronic Annotation more info	PubMed
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in Fc receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of MAP kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of receptor complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: mast/stem cell growth factor receptor Kit

Names: c-kit; proto-oncogene c-Kit; proto-oncogene tyrosine-protein kinase Kit; tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

NP_989692.1

EC 2.7.10.1

XP_046771373.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204361.1 → NP_989692.1 mast/stem cell growth factor receptor Kit precursor

See identical proteins and their annotated locations for NP_989692.1

Status: PROVISIONAL

Source sequence(s)

D13225

UniProtKB/Swiss-Prot

Q08156

Related

ENSGALP00010018822.1, ENSGALT00010032032.1

Conserved Domains (6) summary

cd00096
Location:122 → 184

Ig; Immunoglobulin domain

cd05860
Location:297 → 397

Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)

smart00410
Location:213 → 292

IG_like; Immunoglobulin like

cd05104
Location:539 → 913

PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit

pfam00047
Location:205 → 291

ig; Immunoglobulin domain

pfam07714
Location:575 → 909

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

64787795..64839844 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

64770973..64822939 complement

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GenBank, FASTA, Sequence Viewer (Graphics)