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eEF5 eukaryotic translation elongation factor 5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37846, updated on 27-Mar-2024

Summary

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Official Symbol
eEF5provided by FlyBase
Official Full Name
eukaryotic translation elongation factor 5provided by FlyBase
Primary source
FLYBASE:FBgn0285952
Locus tag
Dmel_CG3186
See related
AllianceGenome:FB:FBgn0285952
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1296; anon-EST:fe2H10; CG3186; chr2R:19566878..19566998; Dmel\CG3186; eIF-5A; eIF5a; eIF5A; l(2)01296; l(2)SH2 2271; l(2)SH2271
Summary
Enables translation elongation factor activity. Involved in multicellular organism reproduction and positive regulation of translational elongation. Predicted to be located in cytoplasm. Is expressed in adult head; adult heart; and organism. Orthologous to several human genes including EIF5A (eukaryotic translation initiation factor 5A) and EIF5A2 (eukaryotic translation initiation factor 5A2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
60B7-60B7; 2-106 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24057798..24059483)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19945321..19947006)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene gamma Soluble NSF attachment protein 1 Neighboring gene seizure Neighboring gene pickpocket 29 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44814 Neighboring gene Ribosomal protein L12 Neighboring gene Ribosomal protein L39 Neighboring gene Ras-associated protein 2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Changes in global translation elongation or initiation rates shape the proteome via the Kozak sequence. Acevedo JM, et al. Sci Rep, 2018 Mar 5. PMID 29507361, Free PMC Article
  2. eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction. Liang Y, et al. Cell Rep, 2021 Apr 13. PMID 33852845
  3. Evolutionary conserved role of eukaryotic translation factor eIF5A in the regulation of actin-nucleating formins. Muñoz-Soriano V, et al. Sci Rep, 2017 Aug 29. PMID 28852021, Free PMC Article
  4. Hypoxia Tolerant Species: The Wisdom of Nature Translated into Targets for Stroke Therapy. Del Río C, et al. Int J Mol Sci, 2021 Oct 15. PMID 34681788, Free PMC Article
  5. The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy. Patel PH, et al. J Cell Biol, 2009 Jun 29. PMID 19546244, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction.
    Title: eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction.
  2. Results describe the identification and characterization of nero, the Drosophila melanogaster deoxyhypusine hydroxylase (DOHH) homologue, and indicate that nero and eIF5A are required for cell growth and affect autophagy and protein synthesis.
    Title: The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation elongation factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables translation elongation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in positive regulation of mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of translational elongation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of translational elongation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of translational elongation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of translational termination IEA
Inferred from Electronic Annotation
more info
  
involved_in sexual reproduction IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
eukaryotic translation elongation factor 5
Names
CG3186-PA
CG3186-PB
anon-fast-evolving-2H10
eEF5-PA
eEF5-PB
eIF-5A
eukaryotic initiation factor 5A
eukaryotic translation factor 5A
lethal (2) SH2271

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24057798..24059483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166654.2 → NP_726411.1  eukaryotic translation elongation factor 5, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726411.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A1B2AK02, Q2MGM4, Q9GU68, Q9NDH0, Q9W1C0
    Related
    FBpp0072081
    Conserved Domains (2) summary
    PLN03107
    Location:1 → 152
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
    pfam01287
    Location:84 → 152
    eIF-5a; Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold

  2. NM_138034.3 → NP_611878.1  eukaryotic translation elongation factor 5, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611878.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A1B2AK02, Q2MGM4, Q9GU68, Q9NDH0, Q9W1C0
    Related
    FBpp0072082
    Conserved Domains (2) summary
    PLN03107
    Location:1 → 152
    PLN03107; eukaryotic translation initiation factor 5A; Provisional
    pfam01287
    Location:84 → 152
    eIF-5a; Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GU68.2 Q9GU68

Gene LinkOut

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