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eIF2Bdelta eukaryotic translation initiation factor 2B subunit delta [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37706, updated on 4-Apr-2024

Summary

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Official Symbol
eIF2Bdeltaprovided by FlyBase
Official Full Name
eukaryotic translation initiation factor 2B subunit deltaprovided by FlyBase
Primary source
FLYBASE:FBgn0034858
Locus tag
Dmel_CG10315
See related
AllianceGenome:FB:FBgn0034858
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10315; Dmel\CG10315; eIF2B-delta
Summary
Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 2B complex. Is expressed in several structures, including adult head; embryonic/larval digestive system; and presumptive embryonic/larval digestive system. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B4 (eukaryotic translation initiation factor 2B subunit delta). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
59D9-59D10; 2-102 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23386521..23389052)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19274044..19276575)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44784 Neighboring gene uncharacterized protein Neighboring gene reduction of Rh1 Neighboring gene Myotubularin related protein 6 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the initiation factor eIF2B and its regulation in Drosophila melanogaster. Williams DD, et al. J Biol Chem, 2001 Feb 9. PMID 11060303
  2. Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR. Vasudevan D, et al. Nat Commun, 2020 Sep 16. PMID 32938929, Free PMC Article
  3. Drosophila TRF2 and TAF9 regulate lipid droplet size and phospholipid fatty acid composition. Fan W, et al. PLoS Genet, 2017 Mar. PMID 28273089, Free PMC Article
  4. Extensive use of RNA-binding proteins in Drosophila sensory neuron dendrite morphogenesis. Olesnicky EC, et al. G3 (Bethesda), 2014 Feb 19. PMID 24347626, Free PMC Article
  5. The translation factors of Drosophila melanogaster. Marygold SJ, et al. Fly (Austin), 2017 Jan 2. PMID 27494710, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of eukaryotic translation initiation factor 2B complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation initiation factor 2B subunit delta
Names
CG10315-PA
CG10315-PB
CG10315-PC
CG10315-PD
eIF2B-delta
eIF2Bdelta-PA
eIF2Bdelta-PB
eIF2Bdelta-PC
eIF2Bdelta-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    23386521..23389052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137946.4 → NP_611790.1  eukaryotic translation initiation factor 2B subunit delta, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611790.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q494L6, Q9W1Q8
    Related
    FBpp0071923
    Conserved Domains (2) summary
    COG1184
    Location:306 → 619
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam01008
    Location:323 → 611
    IF-2B; Initiation factor 2 subunit family

  2. NM_001169794.2 → NP_001163265.1  eukaryotic translation initiation factor 2B subunit delta, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163265.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8X6, Q494L6
    Conserved Domains (2) summary
    COG1184
    Location:256 → 569
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam01008
    Location:273 → 561
    IF-2B; Initiation factor 2 subunit family

  3. NM_166602.3 → NP_726321.1  eukaryotic translation initiation factor 2B subunit delta, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726321.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8X6, Q494L6
    Related
    FBpp0071922
    Conserved Domains (2) summary
    COG1184
    Location:256 → 569
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam01008
    Location:273 → 561
    IF-2B; Initiation factor 2 subunit family

  4. NM_166601.2 → NP_726320.1  eukaryotic translation initiation factor 2B subunit delta, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726320.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E8X6, Q494L6
    Related
    FBpp0071924
    Conserved Domains (2) summary
    COG1184
    Location:256 → 569
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam01008
    Location:273 → 561
    IF-2B; Initiation factor 2 subunit family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0E8X6 Q0E8X6
Q8MPP1 Q8MPP1
Q9W1Q8 Q9W1Q8

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