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PAFAH1B1 platelet activating factor acetylhydrolase 1b regulatory subunit 1 [ Gallus gallus (chicken) ]

Gene ID: 374224, updated on 3-Apr-2024

Summary

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Official Symbol
PAFAH1B1provided by CGNC
Official Full Name
platelet activating factor acetylhydrolase 1b regulatory subunit 1provided by CGNC
Primary source
CGNC:4356
See related
Ensembl:ENSGALG00010029593
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
LIS1
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 19
Exon count:
17
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 19 NC_052550.1 (9923300..9952429)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 19 NC_052591.1 (9660934..9690066)

Chromosome 19 - NC_052550.1Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene microRNA 1592 Neighboring gene MAX network transcriptional repressor Neighboring gene microRNA 1689 Neighboring gene clustered mitochondria homolog Neighboring gene spidroin-1-like Neighboring gene coiled-coil domain containing 92B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of chLIS1, a chicken homolog of LIS1. Shmueli O, et al. Dev Genes Evol, 2000 Jan. PMID 10603088
  2. Cytoplasmic dynein and LIS1 are required for microtubule advance during growth cone remodeling and fast axonal outgrowth. Grabham PW, et al. J Neurosci, 2007 May 23. PMID 17522326, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LIS1/PAFAH1B1 plays a prominent role in microtubule advance during growth cone remodeling associated with axonogenesis.
    Title: Cytoplasmic dynein and LIS1 are required for microtubule advance during growth cone remodeling and fast axonal outgrowth.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intra-Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of COPI vesicle coat IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
lissencephaly-1 homolog
Names
LIS-1
PAF acetylhydrolase 45 kDa subunit
PAF-AH 45 kDa subunit
PAF-AH alpha
PAFAH alpha
chLIS1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
platelet-activating factor acetylhydrolase IB subunit alpha
NP_989655.1
XP_015151145.1
XP_015151146.1
XP_015151147.1
XP_024997649.1
XP_040505935.1
XP_040505936.1
XP_040505937.1
XP_040505939.1
XP_040505940.1
XP_040505941.1
XP_040505942.1
XP_046758238.1
XP_046758239.1
XP_046758240.1
XP_046758241.1
XP_046758242.1
XP_046785830.1
XP_046785831.1
XP_046785833.1
XP_046785834.1
XP_046785835.1
XP_046785836.1
XP_046785837.1
XP_046785838.1
XP_046785839.1
XP_046785840.1
XP_046785841.1
XP_046785842.1
XP_046785844.1
XP_046785845.1
XP_046785846.1
XP_046785847.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204324.2 → NP_989655.1  lissencephaly-1 homolog

    See identical proteins and their annotated locations for NP_989655.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000323
    UniProtKB/Swiss-Prot
    Q9PTR5
    UniProtKB/TrEMBL
    A0A8V1AJB6
    Conserved Domains (3) summary
    smart00667
    Location:7 → 39
    LisH; Lissencephaly type-1-like homology motif
    cd00200
    Location:104 → 408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111 → 148
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052550.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    9923300..9952429
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015295661.4 → XP_015151147.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5
    UniProtKB/TrEMBL
    A0A8V1AJB6
    Conserved Domains (3) summary
    smart00667
    Location:7 → 39
    LisH; Lissencephaly type-1-like homology motif
    cd00200
    Location:104 → 408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111 → 148
    7WD40; WD40 repeat [structural motif]

  2. XM_040650001.2 → XP_040505935.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5
    UniProtKB/TrEMBL
    A0A8V1AJB6
    Conserved Domains (3) summary
    smart00667
    Location:7 → 39
    LisH; Lissencephaly type-1-like homology motif
    cd00200
    Location:104 → 408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111 → 148
    7WD40; WD40 repeat [structural motif]

  3. XM_040650002.2 → XP_040505936.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5
    UniProtKB/TrEMBL
    A0A8V1AJB6
    Conserved Domains (3) summary
    smart00667
    Location:7 → 39
    LisH; Lissencephaly type-1-like homology motif
    cd00200
    Location:104 → 408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111 → 148
    7WD40; WD40 repeat [structural motif]

  4. XM_046902283.1 → XP_046758239.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5

  5. XM_015295660.3 → XP_015151146.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5
    UniProtKB/TrEMBL
    A0A8V1AJB6
    Related
    ENSGALP00010044227.1, ENSGALT00010071537.1
    Conserved Domains (3) summary
    smart00667
    Location:7 → 39
    LisH; Lissencephaly type-1-like homology motif
    cd00200
    Location:104 → 408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111 → 148
    7WD40; WD40 repeat [structural motif]

  6. XM_015295659.4 → XP_015151145.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5
    UniProtKB/TrEMBL
    A0A8V1AJB6
    Related
    ENSGALP00010044228.1, ENSGALT00010071538.1
    Conserved Domains (3) summary
    smart00667
    Location:7 → 39
    LisH; Lissencephaly type-1-like homology motif
    cd00200
    Location:104 → 408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111 → 148
    7WD40; WD40 repeat [structural motif]

  7. XM_046902282.1 → XP_046758238.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5

  8. XM_040650005.2 → XP_040505939.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5
    UniProtKB/TrEMBL
    A0A8V1AJB6
    Conserved Domains (3) summary
    smart00667
    Location:7 → 39
    LisH; Lissencephaly type-1-like homology motif
    cd00200
    Location:104 → 408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111 → 148
    7WD40; WD40 repeat [structural motif]

  9. XM_046902286.1 → XP_046758242.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5

  10. XM_040650003.2 → XP_040505937.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5
    UniProtKB/TrEMBL
    A0A8V1AJB6
    Conserved Domains (3) summary
    smart00667
    Location:7 → 39
    LisH; Lissencephaly type-1-like homology motif
    cd00200
    Location:104 → 408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111 → 148
    7WD40; WD40 repeat [structural motif]

  11. XM_040650006.2 → XP_040505940.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5
    UniProtKB/TrEMBL
    A0A8V1AJB6
    Conserved Domains (3) summary
    smart00667
    Location:7 → 39
    LisH; Lissencephaly type-1-like homology motif
    cd00200
    Location:104 → 408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111 → 148
    7WD40; WD40 repeat [structural motif]

  12. XM_040650008.2 → XP_040505942.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5
    UniProtKB/TrEMBL
    A0A8V1AJB6
    Conserved Domains (3) summary
    smart00667
    Location:7 → 39
    LisH; Lissencephaly type-1-like homology motif
    cd00200
    Location:104 → 408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111 → 148
    7WD40; WD40 repeat [structural motif]

  13. XM_046902284.1 → XP_046758240.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5

  14. XM_040650007.2 → XP_040505941.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5
    UniProtKB/TrEMBL
    A0A8V1AJB6
    Conserved Domains (3) summary
    smart00667
    Location:7 → 39
    LisH; Lissencephaly type-1-like homology motif
    cd00200
    Location:104 → 408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111 → 148
    7WD40; WD40 repeat [structural motif]

  15. XM_025141881.3 → XP_024997649.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5
    UniProtKB/TrEMBL
    A0A8V1AJB6
    Conserved Domains (3) summary
    smart00667
    Location:7 → 39
    LisH; Lissencephaly type-1-like homology motif
    cd00200
    Location:104 → 408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111 → 148
    7WD40; WD40 repeat [structural motif]

  16. XM_046902285.1 → XP_046758241.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052591.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    9660934..9690066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046929877.1 → XP_046785833.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5

  2. XM_046929878.1 → XP_046785834.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5

  3. XM_046929880.1 → XP_046785836.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5

  4. XM_046929885.1 → XP_046785841.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5

  5. XM_046929875.1 → XP_046785831.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5

  6. XM_046929874.1 → XP_046785830.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5

  7. XM_046929884.1 → XP_046785840.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5

  8. XM_046929882.1 → XP_046785838.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5

  9. XM_046929891.1 → XP_046785847.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5

  10. XM_046929881.1 → XP_046785837.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5

  11. XM_046929883.1 → XP_046785839.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5

  12. XM_046929888.1 → XP_046785844.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5

  13. XM_046929889.1 → XP_046785845.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5

  14. XM_046929886.1 → XP_046785842.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5

  15. XM_046929879.1 → XP_046785835.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5

  16. XM_046929890.1 → XP_046785846.1  lissencephaly-1 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9PTR5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9PTR5.3 GenPept UniProtKB/Swiss-Prot:Q9PTR5

Gene LinkOut

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