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HDAC4 histone deacetylase 4 [ Gallus gallus (chicken) ]

Gene ID: 374207, updated on 3-Apr-2024

Summary

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Symbol
HDAC4provided by CGNC
Full Name
histone deacetylase 4provided by CGNC
Primary source
CGNC:49084
See related
Ensembl:ENSGALG00010013697
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
37
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (6244825..6467132, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (6185951..6408143, complement)

Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene pancreas transcription factor 1 subunit alpha-like Neighboring gene uncharacterized LOC121111300 Neighboring gene twist family bHLH transcription factor 2 Neighboring gene uncharacterized LOC121111278 Neighboring gene uncharacterized LOC107053773 Neighboring gene uncharacterized LOC121111301 Neighboring gene uncharacterized LOC107053772

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Subcellular relocation of histone deacetylase 4 regulates growth plate chondrocyte differentiation through Ca2+/calmodulin-dependent kinase IV. Guan Y, et al. Am J Physiol Cell Physiol, 2012 Jul 1. PMID 22442139, Free PMC Article
  2. Ski inhibits TGF-β/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes. Kim KO, et al. J Cell Biochem, 2012 Jun. PMID 22461172, Free PMC Article
  3. CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore. Hori T, et al. Cell, 2008 Dec 12. PMID 19070575
  4. Class II histone deacetylases: versatile regulators. Verdin E, et al. Trends Genet, 2003 May. PMID 12711221
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings indicate that HDAC4 nuclear-cytoplasmic shuttling controls chondrocyte differentiation in the growth plate, which is dependent on the Ca2 /calmodulin signaling pathway
    Title: Subcellular relocation of histone deacetylase 4 regulates growth plate chondrocyte differentiation through Ca2+/calmodulin-dependent kinase IV.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables histone deacetylase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of histone deacetylase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone deacetylase 4
Names
HD4
osteoblast regulatory factor 3A
NP_989644.1
XP_015144578.1
XP_015144579.1
XP_015144581.1
XP_040559165.1
XP_040559166.1
XP_040559167.1
XP_040559169.1
XP_040559170.1
XP_040559171.1
XP_040559172.1
XP_040559173.1
XP_040559175.1
XP_046776842.1
XP_046776843.1
XP_046776845.1
XP_046776846.1
XP_046776847.1
XP_046776848.1
XP_046776849.1
XP_046776851.1
XP_046776852.1
XP_046776853.1
XP_046776854.1
XP_046776855.1
XP_046776856.1
XP_046776857.1
XP_046776858.1
XP_046776859.1
XP_046776860.1
XP_046776861.1
XP_046776862.1
XP_046776863.1
XP_046776864.1
XP_046776865.1
XP_046776866.1
XP_046776867.1
XP_046776868.1
XP_046799334.1
XP_046799335.1
XP_046799336.1
XP_046799337.1
XP_046799338.1
XP_046799340.1
XP_046799341.1
XP_046799342.1
XP_046799343.1
XP_046799344.1
XP_046799345.1
XP_046799347.1
XP_046799348.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204313.2 → NP_989644.1  histone deacetylase 4

    See identical proteins and their annotated locations for NP_989644.1

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000235
    UniProtKB/Swiss-Prot
    P83038
    UniProtKB/TrEMBL
    A0A8V0YF86
    Related
    ENSGALP00010019516.1, ENSGALT00010033011.1
    Conserved Domains (2) summary
    cd10162
    Location:91 → 151
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:645 → 1053
    HDAC4; Histone deacetylase 4

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    6244825..6467132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040703235.2 → XP_040559169.1  histone deacetylase 4 isoform X6

    UniProtKB/TrEMBL
    A0A8V0YF86
    Conserved Domains (2) summary
    cd10162
    Location:91 → 151
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:650 → 1058
    HDAC4; Histone deacetylase 4

  2. XM_040703237.2 → XP_040559171.1  histone deacetylase 4 isoform X7

    UniProtKB/TrEMBL
    A0A8V0YF86
    Conserved Domains (2) summary
    cd10162
    Location:91 → 152
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:649 → 1057
    HDAC4; Histone deacetylase 4

  3. XM_040703238.2 → XP_040559172.1  histone deacetylase 4 isoform X8

    UniProtKB/TrEMBL
    A0A8V0YF86, A0A8V0YLM7
    Related
    ENSGALP00010019511.1, ENSGALT00010033003.1
    Conserved Domains (2) summary
    cd10162
    Location:91 → 152
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:646 → 1054
    HDAC4; Histone deacetylase 4

  4. XM_015289092.4 → XP_015144578.1  histone deacetylase 4 isoform X4

    UniProtKB/TrEMBL
    A0A8V0YF86
    Conserved Domains (2) summary
    cd10162
    Location:91 → 152
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:651 → 1059
    HDAC4; Histone deacetylase 4

  5. XM_046943389.1 → XP_046799345.1  histone deacetylase 4 isoform X13

  6. XM_040703241.2 → XP_040559175.1  histone deacetylase 4 isoform X10

    UniProtKB/TrEMBL
    A0A8V0YF86
    Conserved Domains (2) summary
    cd10162
    Location:91 → 151
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:643 → 1051
    HDAC4; Histone deacetylase 4

  7. XM_040703236.2 → XP_040559170.1  histone deacetylase 4 isoform X6

    UniProtKB/TrEMBL
    A0A8V0YF86
    Conserved Domains (2) summary
    cd10162
    Location:91 → 151
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:650 → 1058
    HDAC4; Histone deacetylase 4

  8. XM_046943384.1 → XP_046799340.1  histone deacetylase 4 isoform X9

  9. XM_040703239.2 → XP_040559173.1  histone deacetylase 4 isoform X8

    UniProtKB/TrEMBL
    A0A8V0YF86, A0A8V0YLM7
    Conserved Domains (2) summary
    cd10162
    Location:91 → 152
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:646 → 1054
    HDAC4; Histone deacetylase 4

  10. XM_040703231.2 → XP_040559165.1  histone deacetylase 4 isoform X4

    UniProtKB/TrEMBL
    A0A8V0YF86
    Conserved Domains (2) summary
    cd10162
    Location:91 → 152
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:651 → 1059
    HDAC4; Histone deacetylase 4

  11. XM_046943385.1 → XP_046799341.1  histone deacetylase 4 isoform X11

  12. XM_046943382.1 → XP_046799338.1  histone deacetylase 4 isoform X3

  13. XM_046943379.1 → XP_046799335.1  histone deacetylase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YF90

  14. XM_046943381.1 → XP_046799337.1  histone deacetylase 4 isoform X2

  15. XM_046943378.1 → XP_046799334.1  histone deacetylase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YF90
    Related
    ENSGALP00010019504.1, ENSGALT00010032991.1

  16. XM_046943388.1 → XP_046799344.1  histone deacetylase 4 isoform X12

    UniProtKB/TrEMBL
    A0A8V0YF76
    Related
    ENSGALP00010019489.1, ENSGALT00010032951.1

  17. XM_040703232.2 → XP_040559166.1  histone deacetylase 4 isoform X4

    UniProtKB/TrEMBL
    A0A8V0YF86
    Conserved Domains (2) summary
    cd10162
    Location:91 → 152
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:651 → 1059
    HDAC4; Histone deacetylase 4

  18. XM_046943380.1 → XP_046799336.1  histone deacetylase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YF90

  19. XM_040703233.2 → XP_040559167.1  histone deacetylase 4 isoform X4

    UniProtKB/TrEMBL
    A0A8V0YF86
    Conserved Domains (2) summary
    cd10162
    Location:91 → 152
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:651 → 1059
    HDAC4; Histone deacetylase 4

  20. XM_046943391.1 → XP_046799347.1  histone deacetylase 4 isoform X14

  21. XM_046943386.1 → XP_046799342.1  histone deacetylase 4 isoform X11

  22. XM_046943392.1 → XP_046799348.1  histone deacetylase 4 isoform X14

  23. XM_046943387.1 → XP_046799343.1  histone deacetylase 4 isoform X11

  24. XM_015289095.4 → XP_015144581.1  histone deacetylase 4 isoform X14

    UniProtKB/TrEMBL
    A0A8V0YF86
    Conserved Domains (2) summary
    cd10162
    Location:64 → 125
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:624 → 1032
    HDAC4; Histone deacetylase 4

  25. XM_015289093.3 → XP_015144579.1  histone deacetylase 4 isoform X5

    UniProtKB/TrEMBL
    A0A8V0YF86
    Conserved Domains (2) summary
    cd10162
    Location:91 → 152
    ClassIIa_HDAC4_Gln-rich-N; Glutamine-rich N-terminal helical domain of HDAC4, a Class IIa histone deacetylase
    cd10006
    Location:651 → 1059
    HDAC4; Histone deacetylase 4

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    6185951..6408143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046920898.1 → XP_046776854.1  histone deacetylase 4 isoform X6

  2. XM_046920900.1 → XP_046776856.1  histone deacetylase 4 isoform X7

  3. XM_046920902.1 → XP_046776858.1  histone deacetylase 4 isoform X8

    UniProtKB/TrEMBL
    A0A8V0YLM7

  4. XM_046920893.1 → XP_046776849.1  histone deacetylase 4 isoform X4

  5. XM_046920909.1 → XP_046776865.1  histone deacetylase 4 isoform X13

  6. XM_046920904.1 → XP_046776860.1  histone deacetylase 4 isoform X10

  7. XM_046920899.1 → XP_046776855.1  histone deacetylase 4 isoform X6

  8. XM_046920903.1 → XP_046776859.1  histone deacetylase 4 isoform X9

  9. XM_046920901.1 → XP_046776857.1  histone deacetylase 4 isoform X8

    UniProtKB/TrEMBL
    A0A8V0YLM7

  10. XM_046920892.1 → XP_046776848.1  histone deacetylase 4 isoform X4

  11. XM_046920905.1 → XP_046776861.1  histone deacetylase 4 isoform X11

  12. XM_046920891.1 → XP_046776847.1  histone deacetylase 4 isoform X3

  13. XM_046920887.1 → XP_046776843.1  histone deacetylase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YF90

  14. XM_046920890.1 → XP_046776846.1  histone deacetylase 4 isoform X2

  15. XM_046920886.1 → XP_046776842.1  histone deacetylase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YF90

  16. XM_046920908.1 → XP_046776864.1  histone deacetylase 4 isoform X12

    UniProtKB/TrEMBL
    A0A8V0YF76

  17. XM_046920896.1 → XP_046776852.1  histone deacetylase 4 isoform X4

  18. XM_046920889.1 → XP_046776845.1  histone deacetylase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YF90

  19. XM_046920895.1 → XP_046776851.1  histone deacetylase 4 isoform X4

  20. XM_046920911.1 → XP_046776867.1  histone deacetylase 4 isoform X14

  21. XM_046920906.1 → XP_046776862.1  histone deacetylase 4 isoform X11

  22. XM_046920912.1 → XP_046776868.1  histone deacetylase 4 isoform X14

  23. XM_046920907.1 → XP_046776863.1  histone deacetylase 4 isoform X11

  24. XM_046920910.1 → XP_046776866.1  histone deacetylase 4 isoform X14

  25. XM_046920897.1 → XP_046776853.1  histone deacetylase 4 isoform X5

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P83038.1 GenPept UniProtKB/Swiss-Prot:P83038

Gene LinkOut

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