U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

JAK2 Janus kinase 2 [ Gallus gallus (chicken) ]

Gene ID: 374199, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Symbol
JAK2provided by CGNC
Full Name
Janus kinase 2provided by CGNC
Primary source
CGNC:11173
See related
Ensembl:ENSGALG00010012833
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
JAK-2
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: Z
Exon count:
27
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (27948291..28033831)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (27948291..28033831)

Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene RNA terminal phosphate cyclase like 1 Neighboring gene microRNA 101-1 Neighboring gene uncharacterized LOC107052272 Neighboring gene uncharacterized LOC107052271 Neighboring gene relaxin 3 Neighboring gene CD274 molecule

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Association of Janus kinase 2 polymorphisms with growth and reproduction traits in chickens. Liu WJ, et al. Poult Sci, 2010 Dec. PMID 21076094
  2. JAK-STAT signaling regulation of chicken embryonic stem cell differentiation into male germ cells. Zhang Y, et al. In Vitro Cell Dev Biol Anim, 2017 Sep. PMID 28597334
  3. JAK2 V617F mutation and PRV-1 overexpression: relevance in the diagnosis of polycythaemia vera and essential thrombocythaemia. Melis S, et al. Acta Clin Belg, 2009 Sep-Oct. PMID 19999391
  4. Comparison of JAK2V617F mutation assessment employing different molecular diagnostic techniques. Veneri D, et al. Blood Transfus, 2009 Jul. PMID 19657484, Free PMC Article
  5. ephA9, a novel avian receptor tyrosine kinase gene. Sasaki E, et al. Gene, 2003 Oct 16. PMID 14563556

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. our results suggested that JAK-STAT effectively promoted the formation of primordial germ cells in the genital ridge during early embryogenesis in vivo and played a positive role in the regulation of embryonic stem cells to spermatogonial stem cells differentiation in vitro, with JAK2 and STAT3 functioning as pivotal factors for intracellular signal transduction
    Title: JAK-STAT signaling regulation of chicken embryonic stem cell differentiation into male germ cells.
  2. It is a gene related to signal transduction.
    Title: Effect of chicken leptin recptor short hairpin RNA on expression of JAK2, STAT3, SOCS3 and CPT1 genes in chicken preadipocytes.
  3. JAK2 polymorphisms may be potential molecular markers to improve laying performance and growth traits in chickens.
    Title: Association of Janus kinase 2 polymorphisms with growth and reproduction traits in chickens.
  4. JAK2 mutation screening is essential in the diagnosis of polycythaemia vera and essential thrombocythaemia.
    Title: JAK2 V617F mutation and PRV-1 overexpression: relevance in the diagnosis of polycythaemia vera and essential thrombocythaemia.
  5. Detection of the JAK2(V617F) mutation may depend on the molecular technique used. Considering that detection of this mutation will not only have a diagnostic value, but also a role in treatment given the development of JAK2(V617F) pathway inhibiting drugs
    Title: Comparison of JAK2V617F mutation assessment employing different molecular diagnostic techniques.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cytokine receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in hemopoiesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
tyrosine-protein kinase JAK2
Names
Janus kinase 2 (a protein tyrosine kinase)
tyrosine kinase
NP_001025709.2
XP_015135543.1
XP_015135545.1
XP_046761136.1
XP_046761137.1
XP_046761138.1
XP_046790608.1
XP_046790609.1
XP_046790610.1
XP_046790611.1
XP_046790612.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030538.3 → NP_001025709.2  tyrosine-protein kinase JAK2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000090
    UniProtKB/Swiss-Prot
    Q75R65
    Related
    ENSGALP00010017849.1, ENSGALT00010030775.1
    Conserved Domains (8) summary
    smart00219
    Location:846 → 1119
    TyrKc; Tyrosine kinase, catalytic domain
    cd10379
    Location:384 → 480
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:37 → 268
    B41; Band 4.1 homologues
    cd13333
    Location:264 → 384
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:542 → 803
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:841 → 1124
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14473
    Location:150 → 259
    FERM_B-lobe; FERM domain B-lobe
    pfam07714
    Location:542 → 802
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    27948291..28033831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046905180.1 → XP_046761136.1  tyrosine-protein kinase JAK2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YH62
    Related
    ENSGALP00010017870.1, ENSGALT00010030804.1

  2. XM_015280057.4 → XP_015135543.1  tyrosine-protein kinase JAK2 isoform X2

    UniProtKB/Swiss-Prot
    Q75R65
    Conserved Domains (8) summary
    smart00219
    Location:846 → 1119
    TyrKc; Tyrosine kinase, catalytic domain
    cd10379
    Location:384 → 480
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:37 → 268
    B41; Band 4.1 homologues
    cd13333
    Location:264 → 384
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:542 → 803
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:841 → 1124
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14473
    Location:150 → 259
    FERM_B-lobe; FERM domain B-lobe
    pfam07714
    Location:542 → 802
    Pkinase_Tyr; Protein tyrosine kinase

  3. XM_046905181.1 → XP_046761137.1  tyrosine-protein kinase JAK2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YH62

  4. XM_015280059.4 → XP_015135545.1  tyrosine-protein kinase JAK2 isoform X2

    UniProtKB/Swiss-Prot
    Q75R65
    Conserved Domains (8) summary
    smart00219
    Location:846 → 1119
    TyrKc; Tyrosine kinase, catalytic domain
    cd10379
    Location:384 → 480
    SH2_Jak2; Src homology 2 (SH2) domain in the Janus kinase 2 (Jak2) proteins
    smart00295
    Location:37 → 268
    B41; Band 4.1 homologues
    cd13333
    Location:264 → 384
    FERM_C_JAK2; FERM domain C-lobe of Janus kinase (JAK) 2
    cd05078
    Location:542 → 803
    PTK_Jak2_rpt1; Pseudokinase (repeat 1) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14205
    Location:841 → 1124
    PTKc_Jak2_rpt2; Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2
    cd14473
    Location:150 → 259
    FERM_B-lobe; FERM domain B-lobe
    pfam07714
    Location:542 → 802
    Pkinase_Tyr; Protein tyrosine kinase

  5. XM_046905182.1 → XP_046761138.1  tyrosine-protein kinase JAK2 isoform X2

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    27948291..28033831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046934652.1 → XP_046790608.1  tyrosine-protein kinase JAK2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YH62

  2. XM_046934654.1 → XP_046790610.1  tyrosine-protein kinase JAK2 isoform X2

  3. XM_046934653.1 → XP_046790609.1  tyrosine-protein kinase JAK2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YH62

  4. XM_046934655.1 → XP_046790611.1  tyrosine-protein kinase JAK2 isoform X2

  5. XM_046934656.1 → XP_046790612.1  tyrosine-protein kinase JAK2 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q75R65.1 GenPept UniProtKB/Swiss-Prot:Q75R65

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous