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APP amyloid beta precursor protein [ Gallus gallus (chicken) ]

Gene ID: 374198, updated on 3-Apr-2024

Summary

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Symbol
APPprovided by CGNC
Full Name
amyloid beta precursor proteinprovided by CGNC
Primary source
CGNC:49081
See related
Ensembl:ENSGALG00010010915
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
19
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (102713380..102912757, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (102800498..103000501, complement)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene junctional adhesion molecule 2 Neighboring gene ATP synthase, H+ transporting, mitochondrial Fo complex subunit F6 Neighboring gene GA binding protein transcription factor alpha subunit Neighboring gene cysteine and tyrosine rich 1 Neighboring gene uncharacterized LOC124417328 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hen lysozyme amyloid fibrils induce aggregation of erythrocytes and lipid vesicles. Chaudhary N, et al. Mol Cell Biochem, 2009 Aug. PMID 19322639
  2. What the evolution of the amyloid protein precursor supergene family tells us about its function. Coulson EJ, et al. Neurochem Int, 2000 Mar. PMID 10676850
  3. Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons. Barnes NY, et al. J Neurosci, 1998 Aug 1. PMID 9671674, Free PMC Article
  4. Nonspecific Amyloid Aggregation of Chicken Smooth-Muscle Titin: In Vitro Investigations. Bobylev AG, et al. Int J Mol Sci, 2023 Jan 5. PMID 36674570, Free PMC Article
  5. Inhibition of choline acetyltransferase as a mechanism for cholinergic dysfunction induced by amyloid-β peptide oligomers. Nunes-Tavares N, et al. J Biol Chem, 2012 Jun 1. PMID 22505713, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nonspecific Amyloid Aggregation of Chicken Smooth-Muscle Titin: In Vitro Investigations.
    Title: Nonspecific Amyloid Aggregation of Chicken Smooth-Muscle Titin: In Vitro Investigations.
  2. Reduction in ChAT activity instigated by AbetaOs may thus be a relevant event in early stage AD pathology, preceding the loss of cholinergic neurons commonly observed in AD brains.
    Title: Inhibition of choline acetyltransferase as a mechanism for cholinergic dysfunction induced by amyloid-β peptide oligomers.
  3. Results compare the effect of secretase inhibitors and modulators on Abeta formation in primary chicken telencephalic neurons and in a human neuroglioma cell line (H4) ectopically expressing human APP with the Swedish double mutation.
    Title: Comparison of pharmacological modulation of APP metabolism in primary chicken telencephalic neurons and in a human neuroglioma cell line.
  4. fibrils caused extensive aggregation of human erythrocytes and lipid vesicles without any significant lysis
    Title: Hen lysozyme amyloid fibrils induce aggregation of erythrocytes and lipid vesicles.
  5. A "CAGA" sequence proximal to the "ATG" start codon & immediately upstream of an interleukin-1-responsive element was found in a location unique to APP genes of amyloid plaque-forming species & absent in all other genes surveyed.
    Title: Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transition metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in axonogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in central nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
amyloid-beta precursor protein
Names
amyloid beta A4 protein
amyloid protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204308.2 → NP_989639.2  amyloid-beta precursor protein precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000020
    UniProtKB/TrEMBL
    Q9DGJ7
    Related
    ENSGALP00010014789.1, ENSGALT00010026165.1
    Conserved Domains (5) summary
    smart00006
    Location:24 → 188
    A4_EXTRA; amyloid A4
    COG0419
    Location:365 → 561
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00109
    Location:295 → 342
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    pfam03494
    Location:658 → 694
    Beta-APP; Beta-amyloid peptide (beta-APP)
    cl21478
    Location:338 → 444
    ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    102713380..102912757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015299094.4 → XP_015154580.2  amyloid-beta precursor protein isoform X1

    UniProtKB/TrEMBL
    Q9DGJ8
    Conserved Domains (3) summary
    smart00006
    Location:24 → 188
    A4_EXTRA; amyloid A4
    PRK05035
    Location:318 → 449
    PRK05035; electron transport complex protein RnfC; Provisional
    pfam03494
    Location:602 → 638
    Beta-APP; Beta-amyloid peptide (beta-APP)

  2. XM_046943383.1 → XP_046799339.1  amyloid-beta precursor protein isoform X3

    UniProtKB/TrEMBL
    A0A8V0Y2F5

  3. XM_046943439.1 → XP_046799395.1  amyloid-beta precursor protein isoform X2

  4. XM_046943417.1 → XP_046799373.1  amyloid-beta precursor protein isoform X3

    UniProtKB/TrEMBL
    A0A8V0Y2F5
    Related
    ENSGALP00010014791.1, ENSGALT00010026167.1

  5. XM_046943352.1 → XP_046799308.1  amyloid-beta precursor protein isoform X2

    Related
    ENSGALP00010014775.1, ENSGALT00010026151.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    102800498..103000501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046906416.1 → XP_046762372.1  amyloid-beta precursor protein isoform X1

  2. XM_046906418.1 → XP_046762374.1  amyloid-beta precursor protein isoform X3

  3. XM_046906419.1 → XP_046762375.1  amyloid-beta precursor protein isoform X2

  4. XM_046906417.1 → XP_046762373.1  amyloid-beta precursor protein isoform X2

Nucleotide Protein
Heading Accession and Version

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