PDGFA platelet derived growth factor subunit A [Gallus gallus (chicken)] - Gene

Summary

Symbol: PDGFAprovided by CGNC
Full Name: platelet derived growth factor subunit Aprovided by CGNC
Primary source: CGNC:49079
See related: Ensembl:ENSGALG00010022164
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: PDGF-A
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	14	NC_052545.1 (1998800..2019762, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	14	NC_052586.1 (1997061..2017989, complement)

Chromosome 14 - NC_052545.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results describe the expression patterns of PDGF-A, -C, and their receptor PDGFR-alpha during avian heart development.
Title: Platelet-derived growth factor is involved in the differentiation of second heart field-derived cardiac structures in chicken embryos.
PDGF signalling activates the PI3 kinase signalling pathway in vivo and activation of this pathway is required for proper N-cadherin expression.
Title: PDGF signalling controls the migration of mesoderm cells during chick gastrulation by regulating N-cadherin expression.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables platelet-derived growth factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in platelet-derived growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of MAP kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of protein autophosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: platelet-derived growth factor subunit A

Names: PDGF-A (S1); platelet-derived growth factor A chain long form; platelet-derived growth factor A chain short form type 1; platelet-derived growth factor A chain short form type 2; platelet-derived growth factor A-chain; platelet-derived growth factor alpha polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204306.1 → NP_989637.1 platelet-derived growth factor subunit A preproprotein

See identical proteins and their annotated locations for NP_989637.1

Status: VALIDATED

Source sequence(s)

AB031023

UniProtKB/TrEMBL

Q90WK1, Q90WK3

Related

ENSGALP00010032473.1, ENSGALT00010053922.1

Conserved Domains (2) summary

smart00141
Location:94 → 179

PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

pfam04692
Location:21 → 95

PDGF_N; Platelet-derived growth factor, N terminal region

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052545.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

1998800..2019762 complement

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GenBank, FASTA, Sequence Viewer (Graphics)