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PSEN2 presenilin 2 [ Gallus gallus (chicken) ]

Gene ID: 374188, updated on 3-Apr-2024

Summary

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Symbol
PSEN2provided by CGNC
Full Name
presenilin 2provided by CGNC
Primary source
CGNC:6904
See related
Ensembl:ENSGALG00010018045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
PS2; presenilin-2
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
13
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (12189968..12208108, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (12101615..12119763, complement)

Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene CDC42 binding protein kinase alpha Neighboring gene heterogeneous nuclear ribonucleoprotein H3-like Neighboring gene coenzyme Q8A Neighboring gene inositol-trisphosphate 3-kinase C Neighboring gene microRNA 6631 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of the presenilins in hematopoietic cells with localization of presenilin 1 to neutrophil and platelet granules. Mirinics ZK, et al. Blood Cells Mol Dis, 2002 Jan-Feb. PMID 11987239
  2. The chick embryo appears as a natural model for research in beta-amyloid precursor protein processing. Carrodeguas JA, et al. Neuroscience, 2005. PMID 16039787
  3. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aspartic endopeptidase activity, intramembrane cleaving IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch receptor processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in amyloid precursor protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in amyloid-beta metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in ciliary rootlet IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in dendritic shaft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
presenilin-2
Names
PS-2
NP_989633.2
XP_015138918.1
XP_025004248.1
XP_040552646.1
XP_046768840.1
XP_046768842.1
XP_046768843.1
XP_046768844.1
XP_046768845.1
XP_046768846.1
XP_046768847.1
XP_046768848.1
XP_046794341.1
XP_046794342.1
XP_046794343.1
XP_046794344.1
XP_046794346.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204302.3 → NP_989633.2  presenilin-2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000062
    UniProtKB/TrEMBL
    A0A1D5PZQ7, F1NGP7, Q5QHS2
    Conserved Domains (1) summary
    pfam01080
    Location:88 → 445
    Presenilin

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    12189968..12208108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015283432.4 → XP_015138918.1  presenilin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z5X8, Q5QHS2
    Related
    ENSGALP00010025956.1, ENSGALT00010043635.1
    Conserved Domains (1) summary
    pfam01080
    Location:88 → 446
    Presenilin

  2. XM_046938386.1 → XP_046794342.1  presenilin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z5X8

  3. XM_046938388.1 → XP_046794344.1  presenilin-2 isoform X2

    UniProtKB/TrEMBL
    A0A1D5PZQ7, F1NGP7

  4. XM_046938385.1 → XP_046794341.1  presenilin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z5X8
    Related
    ENSGALP00010025948.1, ENSGALT00010043624.1

  5. XM_046938390.1 → XP_046794346.1  presenilin-2 isoform X2

    UniProtKB/TrEMBL
    A0A1D5PZQ7, F1NGP7
    Related
    ENSGALP00010025967.1, ENSGALT00010043645.1

  6. XM_046938387.1 → XP_046794343.1  presenilin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z5X8

  7. XM_040696712.2 → XP_040552646.1  presenilin-2 isoform X2

    UniProtKB/TrEMBL
    A0A1D5PZQ7, F1NGP7, Q5QHS2
    Conserved Domains (1) summary
    pfam01080
    Location:88 → 445
    Presenilin

  8. XM_025148480.3 → XP_025004248.1  presenilin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z5X8, Q5QHS2
    Conserved Domains (1) summary
    pfam01080
    Location:88 → 446
    Presenilin

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    12101615..12119763 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046912884.1 → XP_046768840.1  presenilin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z5X8

  2. XM_046912888.1 → XP_046768844.1  presenilin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z5X8

  3. XM_046912891.1 → XP_046768847.1  presenilin-2 isoform X2

    UniProtKB/TrEMBL
    A0A1D5PZQ7, F1NGP7

  4. XM_046912887.1 → XP_046768843.1  presenilin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z5X8

  5. XM_046912892.1 → XP_046768848.1  presenilin-2 isoform X2

    UniProtKB/TrEMBL
    A0A1D5PZQ7, F1NGP7

  6. XM_046912889.1 → XP_046768845.1  presenilin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z5X8

  7. XM_046912890.1 → XP_046768846.1  presenilin-2 isoform X2

    UniProtKB/TrEMBL
    A0A1D5PZQ7, F1NGP7

  8. XM_046912886.1 → XP_046768842.1  presenilin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0Z5X8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q90X07.1 GenPept UniProtKB/Swiss-Prot:Q90X07

Gene LinkOut

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