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CAMK2A calcium/calmodulin dependent protein kinase II alpha [ Gallus gallus (chicken) ]

Gene ID: 374175, updated on 3-Apr-2024

Summary

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Symbol
CAMK2Aprovided by CGNC
Full Name
calcium/calmodulin dependent protein kinase II alphaprovided by CGNC
Primary source
CGNC:49072
See related
Ensembl:ENSGALG00010013576
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 13
Exon count:
19
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 13 NC_052544.1 (12795785..12818019)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 13 NC_052585.1 (12809568..12831807)

Chromosome 13 - NC_052544.1Genomic Context describing neighboring genes Neighboring gene treacle ribosome biogenesis factor 1 Neighboring gene uncharacterized LOC121106738 Neighboring gene arylsulfatase family member I Neighboring gene solute carrier family 6 member 7 Neighboring gene caudal type homeobox 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ca2+/calmodulin protein kinase II and memory: learning-related changes in a localized region of the domestic chick brain. Solomonia RO, et al. J Physiol, 2005 Dec 1. PMID 16179361, Free PMC Article
  2. Subcellular relocation of histone deacetylase 4 regulates growth plate chondrocyte differentiation through Ca2+/calmodulin-dependent kinase IV. Guan Y, et al. Am J Physiol Cell Physiol, 2012 Jul 1. PMID 22442139, Free PMC Article
  3. Molecular cloning and analysis of Ca2+/calmodulin-dependent protein kinase II from the chicken brain. Li G, et al. J Mol Neurosci, 1998 Oct. PMID 10096040
  4. Ca(2+)/CaM-dependent kinases: from activation to function. Hook SS, et al. Annu Rev Pharmacol Toxicol, 2001. PMID 11264466

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CaMKIV induces chondrocyte differentiation through regulation of HDAC4 subcellular relocation, from the nucleus to the cytoplasm, which results in increased activity of RunX2 and transition of chondrocytes from the proliferative to prehypertrophic stage
    Title: Subcellular relocation of histone deacetylase 4 regulates growth plate chondrocyte differentiation through Ca2+/calmodulin-dependent kinase IV.
  2. results suggest that alphaCaMKII is involved in the formation of memory but not in its maintenance
    Title: Ca2+/calmodulin protein kinase II and memory: learning-related changes in a localized region of the domestic chick brain.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calmodulin-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calcium/calmodulin-dependent protein kinase type II subunit alpha
Names
calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
NP_989626.2
XP_015149205.2
XP_015149207.2
XP_040502746.1
XP_046782708.1
XP_046782709.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204295.2 → NP_989626.2  calcium/calmodulin-dependent protein kinase type II subunit alpha

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000256
    UniProtKB/TrEMBL
    F1NGS8, O93559
    Related
    ENSGALP00010019412.1, ENSGALT00010032768.1
    Conserved Domains (2) summary
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:357 → 484
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052544.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    12795785..12818019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015293719.4 → XP_015149205.2  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X3

    UniProtKB/TrEMBL
    O93559
    Conserved Domains (2) summary
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:357 → 484
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  2. XM_015293721.4 → XP_015149207.2  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1

    UniProtKB/TrEMBL
    Q9YHB8
    Conserved Domains (2) summary
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:346 → 473
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  3. XM_040646812.2 → XP_040502746.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2

    UniProtKB/TrEMBL
    F1P011, Q9YHB8
    Related
    ENSGALP00010019402.1, ENSGALT00010032751.1
    Conserved Domains (2) summary
    cd14086
    Location:11 → 302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:346 → 473
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052585.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    12809568..12831807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046926752.1 → XP_046782708.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2

    UniProtKB/TrEMBL
    F1P011

  2. XM_046926753.1 → XP_046782709.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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