U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

WNT7A Wnt family member 7A [ Gallus gallus (chicken) ]

Gene ID: 374168, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Symbol
WNT7Aprovided by CGNC
Full Name
Wnt family member 7Aprovided by CGNC
Primary source
CGNC:3813
See related
Ensembl:ENSGALG00010027653
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 12
Exon count:
4
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 12 NC_052543.1 (6213260..6249706, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 12 NC_052584.1 (6239846..6276326, complement)

Chromosome 12 - NC_052543.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121106654 Neighboring gene fibulin 2 Neighboring gene uncharacterized LOC112533383 Neighboring gene uncharacterized LOC121106653 Neighboring gene uncharacterized LOC121106652 Neighboring gene microRNA let-7f-1 Neighboring gene microRNA let-7d

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Shaping organs by a wingless-int/Notch/nonmuscle myosin module which orients feather bud elongation. Li A, et al. Proc Natl Acad Sci U S A, 2013 Apr 16. PMID 23576731, Free PMC Article
  2. Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin. Long K, et al. Nat Commun, 2016 Feb 3. PMID 26838601, Free PMC Article
  3. Involvement of frizzled-10 in Wnt-7a signaling during chick limb development. Kawakami Y, et al. Dev Growth Differ, 2000 Dec. PMID 11142678
  4. Mutations in WNT7A cause a range of limb malformations, including Fuhrmann syndrome and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome. Woods CG, et al. Am J Hum Genet, 2006 Aug. PMID 16826533, Free PMC Article
  5. Expression patterns of Wnt genes during development of an anterior part of the chicken eye. Fokina VM, et al. Dev Dyn, 2006 Feb. PMID 16258938, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The integrin-Wnt7a-Decorin pathway promotes proliferation and differentiation of neuroepithelial cells.
    Title: Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin.
  2. Wingless-int (Wnt)7a protein induces beta-catenin expression in the developing feather bud.
    Title: Shaping organs by a wingless-int/Notch/nonmuscle myosin module which orients feather bud elongation.
  3. Wild-type overexpression of WNT7A in developing cultured chick limb causes a strong inhibition of chondrogenesis, repression of alkaline phosphatase, and the tendency to detach from the culture dish.
    Title: Mutations in WNT7A cause a range of limb malformations, including Fuhrmann syndrome and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndrome.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables frizzled binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell fate commitment IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
protein Wnt-7a
Names
wingless-type MMTV integration site family, member 7A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204292.3 → NP_989623.1  protein Wnt-7a

    See identical proteins and their annotated locations for NP_989623.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000252
    UniProtKB/TrEMBL
    F1NWN0, Q9DEB8
    Related
    ENSGALP00010040983.1, ENSGALT00010067025.1
    Conserved Domains (1) summary
    cd19349
    Location:32 → 349
    Wnt_Wnt7a; Wnt domain found in protein Wnt-7a and similar proteins

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052543.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    6213260..6249706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052584.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    6239846..6276326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous