DFFB DNA fragmentation factor subunit beta [Gallus gallus (chicken)] - Gene

Summary

Symbol: DFFBprovided by CGNC
Full Name: DNA fragmentation factor subunit betaprovided by CGNC
Primary source: CGNC:645
See related: Ensembl:ENSGALG00010021223
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	21	NC_052552.1 (898392..912433, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	21	NC_052593.1 (930073..944114, complement)

Chromosome 21 - NC_052552.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CAD(caspase activated DNase)is a neutral DNase associated with the caspase apoptotic pathway which appears to be the main endonuclease only at an initial phase of the interdigit regression.
Title: Coordinated and sequential activation of neutral and acidic DNases during interdigital cell death in the embryonic limb.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA endonuclease activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic DNA fragmentation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: DNA fragmentation factor subunit beta

Names: DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204285.2 → NP_989616.1 DNA fragmentation factor subunit beta

See identical proteins and their annotated locations for NP_989616.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000329

UniProtKB/TrEMBL

Q8UVS5

Related

ENSGALP00010030627.1, ENSGALT00010051436.1

Conserved Domains (2) summary

cd06535
Location:4 → 80

CIDE_N_CAD; CIDE_N domain of CAD nuclease. The CIDE_N (cell death-inducing DFF45-like effector, N-terminal) domain is found at the N-terminus of CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are ...

pfam09230
Location:100 → 324

DFF40; DNA fragmentation factor 40 kDa

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052552.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

898392..912433 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015296808.4 → XP_015152294.2 DNA fragmentation factor subunit beta isoform X2

Conserved Domains (1) summary

cl02541
Location:4 → 80

CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...
XM_015296807.4 → XP_015152293.2 DNA fragmentation factor subunit beta isoform X1

UniProtKB/TrEMBL

A0A8V0ZPI3

Related

ENSGALP00010030632.1, ENSGALT00010051441.1

Conserved Domains (1) summary

cl02541
Location:4 → 80

CIDE_N; CIDE_N domain, found at the N-terminus of the CIDE (cell death-inducing DFF45-like effector) proteins, as well as CAD nuclease (caspase-activated DNase/DNA fragmentation factor, DFF40) and its inhibitor, ICAD(DFF45). These proteins are associated with ...
XM_040651092.2 → XP_040507026.2 DNA fragmentation factor subunit beta isoform X3
XM_046903096.1 → XP_046759052.1 DNA fragmentation factor subunit beta isoform X4

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052593.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

930073..944114 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046931120.1 → XP_046787076.1 DNA fragmentation factor subunit beta isoform X2
XM_046931119.1 → XP_046787075.1 DNA fragmentation factor subunit beta isoform X1

UniProtKB/TrEMBL

A0A8V0ZPI3
XM_046931121.1 → XP_046787077.1 DNA fragmentation factor subunit beta isoform X3
XM_046931122.1 → XP_046787078.1 DNA fragmentation factor subunit beta isoform X4